| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 3,276,522 | 74,869,000 | 17.62% | ||
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,613,284 | 36,864,000 | 8.67% | ||
| 3 | STATE STREET CORP | 1,114,514 | 25,468,000 | 5.99% | ||
| 4 | Versant Venture Management, LLC | 1,092,152 | 24,955,673 | 5.87% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,049,625 | 23,984,000 | 5.64% | ||
| 6 | Point72 Asset Management, L.P. | 1,024,700 | 23,414,000 | 5.51% | ||
| 7 | BlackRock Fund Advisors | 886,238 | 20,251,000 | 4.77% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 839,400 | 19,180,000 | 4.51% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 622,610 | 14,227,000 | 3.35% | ||
| 10 | VANGUARD GROUP INC | 529,717 | 12,104,000 | 2.85% | ||
| 11 | BVF INC/IL | 502,832 | 11,490,000 | 2.70% | ||
| 12 | PUTNAM INVESTMENTS LLC | 444,300 | 10,152,000 | 2.39% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 433,276 | 9,900,000 | 2.33% | ||
| 14 | QVT Financial LP | 406,457 | 9,288,000 | 2.19% | ||
| 15 | EverPoint Asset Management, LLC | 350,384 | 8,006,000 | 1.88% | ||
| 16 | AWM Investment Company, Inc. | 300,000 | 6,855,000 | 1.61% | ||
| 17 | Numeric Investors LLC | 276,453 | 6,317,000 | 1.49% | ||
| 18 | D. E. Shaw & Co., Inc. | 259,149 | 5,922,000 | 1.39% | ||
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 244,988 | 5,598,000 | 1.32% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 224,129 | 5,121,000 | 1.20% | ||
| 21 | NORTHERN TRUST CORP | 216,808 | 4,954,000 | 1.17% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 171,155 | 3,910,000 | 0.92% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 143,200 | 3,272,000 | 0.77% | ||
| 24 | Aureus Asset Management, LLC | 141,870 | 3,242,000 | 0.76% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 141,241 | 3,226,000 | 0.76% | ||
| 26 | Rock Springs Capital Management LP | 136,000 | 3,108,000 | 0.73% | ||
| 27 | Spark Investment Management LLC | 126,112 | 2,882,000 | 0.68% | ||
| 28 | BLACKROCK ADVISORS LLC | 120,320 | 2,749,000 | 0.65% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 119,494 | 2,730,000 | 0.64% | ||
| 30 | WELLS FARGO & COMPANY/MN | 107,843 | 2,465,000 | 0.58% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 103,700 | 2,370,000 | 0.56% | ||
| 32 | Ghost Tree Capital, LLC | 100,000 | 2,285,000 | 0.54% | ||
| 33 | AQR CAPITAL MANAGEMENT LLC | 91,200 | 2,084,000 | 0.49% | ||
| 34 | CITIGROUP INC | 90,059 | 2,058,000 | 0.48% | ||
| 35 | Bank of New York Mellon Corp | 87,047 | 1,989,000 | 0.47% | ||
| 36 | MORGAN STANLEY | 76,865 | 1,757,000 | 0.41% | ||
| 37 | TFS CAPITAL LLC | 65,905 | 1,506,000 | 0.35% | ||
| 38 | BlackRock Investment Management, LLC | 59,102 | 1,350,000 | 0.32% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 58,000 | 1,325,000 | 0.31% | ||
| 40 | TWO SIGMA INVESTMENTS, LP | 48,448 | 1,107,000 | 0.26% | ||
| 41 | Nationwide Fund Advisors | 46,198 | 1,056,000 | 0.25% | ||
| 42 | Informed Momentum Co LLC | 44,488 | 1,017,000 | 0.24% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 41,600 | 951,000 | 0.22% | ||
| 44 | CREDIT SUISSE AG/ | 40,790 | 932,000 | 0.22% | ||
| 45 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | 914,000 | 0.22% | ||
| 46 | SMITH ASSET MANAGEMENT GROUP LP | 39,250 | 897,000 | 0.21% | ||
| 47 | GSA CAPITAL PARTNERS LLP | 38,896 | 889,000 | 0.21% | ||
| 48 | RUSSELL FRANK CO/ | 38,562 | 881,000 | 0.21% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,217 | 850,000 | 0.20% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,300 | 761,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
