| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
2,147,105 |
25,186,000 |
17.54% |
|
|
| 2 |
BVF INC/IL |
1,461,900 |
17,148,000 |
11.94% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,075,400 |
12,614,000 |
8.78% |
|
|
| 4 |
TPG Group Holdings (SBS) Advisors, Inc. |
1,053,692 |
12,360,000 |
8.61% |
|
|
| 5 |
EVENTIDE ASSET MANAGEMENT, LLC |
773,600 |
9,074,000 |
6.32% |
|
|
| 6 |
QVT Financial LP |
645,705 |
7,574,000 |
5.27% |
|
|
| 7 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
500,000 |
5,865,000 |
4.08% |
|
|
| 8 |
GOLDMAN SACHS GROUP INC |
474,372 |
5,564,000 |
3.87% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
444,300 |
5,212,000 |
3.63% |
|
|
| 10 |
BlackRock Fund Advisors |
412,606 |
4,840,000 |
3.37% |
|
|
| 11 |
VANGUARD GROUP INC |
305,907 |
3,589,000 |
2.50% |
|
|
| 12 |
MARXE AUSTIN W & GREENHOUSE DAVID M |
300,000 |
3,519,000 |
2.45% |
|
|
| 13 |
SENZAR ASSET MANAGEMENT, LLC |
298,300 |
3,499,000 |
2.44% |
|
|
| 14 |
PRICE T ROWE ASSOCIATES INC /MD/ |
250,815 |
2,942,000 |
2.05% |
|
|
| 15 |
MILLENNIUM MANAGEMENT LLC |
202,433 |
2,375,000 |
1.65% |
|
|
| 16 |
STATE STREET CORP |
189,016 |
2,216,000 |
1.54% |
|
|
| 17 |
NORTHERN TRUST CORP |
167,172 |
1,961,000 |
1.37% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
162,579 |
1,907,000 |
1.33% |
|
|
| 19 |
WELLS FARGO & COMPANY/MN |
154,812 |
1,816,000 |
1.26% |
|
|
| 20 |
PERCEPTIVE ADVISORS LLC |
150,000 |
1,760,000 |
1.23% |
|
|
| 21 |
Rock Springs Capital Management LP |
115,000 |
1,349,000 |
0.94% |
|
|
| 22 |
MASON STREET ADVISORS, LLC |
107,620 |
1,262,000 |
0.88% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
90,000 |
1,056,000 |
0.74% |
|
|
| 24 |
Bank of New York Mellon Corp |
67,899 |
796,000 |
0.55% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
63,307 |
743,000 |
0.52% |
|
|
| 26 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
59,000 |
692,000 |
0.48% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
53,263 |
624,000 |
0.43% |
|
|
| 28 |
BlackRock Investment Management, LLC |
50,098 |
588,000 |
0.41% |
|
|
| 29 |
Numeric Investors LLC |
46,049 |
540,000 |
0.38% |
|
|
| 30 |
Nationwide Fund Advisors |
36,546 |
429,000 |
0.30% |
|
|
| 31 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
32,660 |
383,000 |
0.27% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
31,681 |
372,000 |
0.26% |
|
|
| 33 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
25,700 |
301,000 |
0.21% |
|
|
| 34 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
25,300 |
297,000 |
0.21% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
23,987 |
281,000 |
0.20% |
|
|
| 36 |
MORGAN STANLEY |
22,921 |
269,000 |
0.19% |
|
|
| 37 |
REGENTS OF THE UNIVERSITY OF CALIFORNIA |
22,214 |
261,000 |
0.18% |
|
|
| 38 |
BAKER BROS. ADVISORS LP |
19,823 |
233,000 |
0.16% |
|
|
| 39 |
TFS CAPITAL LLC |
19,553 |
229,000 |
0.16% |
|
|
| 40 |
JPMORGAN CHASE & CO |
16,791 |
197,000 |
0.14% |
|
|
| 41 |
METROPOLITAN LIFE INSURANCE CO/NY |
14,105 |
165,000 |
0.11% |
|
|
| 42 |
RHUMBLINE ADVISERS |
12,820 |
150,000 |
0.10% |
|
|
| 43 |
VOYA INVESTMENT MANAGEMENT LLC |
12,705 |
149,000 |
0.10% |
|
|
| 44 |
CITADEL ADVISORS LLC |
12,020 |
141,000 |
0.10% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
11,270 |
132,197 |
0.09% |
|
|
| 46 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
11,293 |
132,000 |
0.09% |
|
|
| 47 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
11,225 |
132,000 |
0.09% |
|
|
| 48 |
PNC FINANCIAL SERVICES GROUP, INC. |
11,120 |
131,000 |
0.09% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,701 |
126,000 |
0.09% |
|
|
| 50 |
DEUTSCHE BANK AG\ |
7,897 |
91,000 |
0.06% |
|
|
