| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 2,290,999 | 61,856,000 | 16.95% | ||
| 2 | TPG Group Holdings (SBS) Advisors, Inc. | 1,053,692 | 28,450,000 | 7.80% | ||
| 3 | Versant Venture Management, LLC | 1,092,152 | 24,955,673 | 6.84% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 919,882 | 24,837,000 | 6.81% | ||
| 5 | BVF INC/IL | 826,332 | 22,311,000 | 6.11% | ||
| 6 | EVENTIDE ASSET MANAGEMENT, LLC | 784,000 | 21,168,000 | 5.80% | ||
| 7 | BlackRock Fund Advisors | 729,492 | 19,696,000 | 5.40% | ||
| 8 | Point72 Asset Management, L.P. | 567,400 | 15,320,000 | 4.20% | ||
| 9 | QVT Financial LP | 498,392 | 13,457,000 | 3.69% | ||
| 10 | PUTNAM INVESTMENTS LLC | 444,300 | 11,996,000 | 3.29% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 417,610 | 11,275,000 | 3.09% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 345,772 | 9,336,000 | 2.56% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 332,474 | 8,977,000 | 2.46% | ||
| 14 | VANGUARD GROUP INC | 311,479 | 8,410,000 | 2.30% | ||
| 15 | AWM Investment Company, Inc. | 300,000 | 8,100,000 | 2.22% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 268,430 | 7,248,000 | 1.99% | ||
| 17 | STATE STREET CORP | 208,131 | 5,623,000 | 1.54% | ||
| 18 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 181,118 | 4,890,000 | 1.34% | ||
| 19 | NORTHERN TRUST CORP | 165,415 | 4,466,000 | 1.22% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 155,256 | 4,192,000 | 1.15% | ||
| 21 | EverPoint Asset Management, LLC | 150,000 | 4,050,000 | 1.11% | ||
| 22 | WELLS FARGO & COMPANY/MN | 130,455 | 3,523,000 | 0.97% | ||
| 23 | Rock Springs Capital Management LP | 120,000 | 3,240,000 | 0.89% | ||
| 24 | BLACKROCK ADVISORS LLC | 106,200 | 2,867,000 | 0.79% | ||
| 25 | MASON STREET ADVISORS, LLC | 98,065 | 2,648,000 | 0.73% | ||
| 26 | DRIEHAUS CAPITAL MANAGEMENT LLC | 80,376 | 2,170,000 | 0.59% | ||
| 27 | TFS CAPITAL LLC | 74,239 | 2,004,000 | 0.55% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 71,377 | 1,927,000 | 0.53% | ||
| 29 | Weiss Multi-Strategy Advisers LLC | 70,000 | 1,890,000 | 0.52% | ||
| 30 | D. E. Shaw & Co., Inc. | 69,740 | 1,883,000 | 0.52% | ||
| 31 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 69,000 | 1,863,000 | 0.51% | ||
| 32 | Bank of New York Mellon Corp | 63,996 | 1,728,000 | 0.47% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 56,840 | 1,535,000 | 0.42% | ||
| 34 | BlackRock Investment Management, LLC | 49,779 | 1,344,000 | 0.37% | ||
| 35 | PRUDENTIAL FINANCIAL INC | 43,700 | 1,180,000 | 0.32% | ||
| 36 | Invesco Ltd. | 41,683 | 1,125,000 | 0.31% | ||
| 37 | Nationwide Fund Advisors | 34,386 | 928,000 | 0.25% | ||
| 38 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 33,395 | 902,000 | 0.25% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,817 | 859,000 | 0.24% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 25,700 | 703,000 | 0.19% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,300 | 684,000 | 0.19% | ||
| 42 | TEACHERS ADVISORS, LLC | 23,987 | 648,000 | 0.18% | ||
| 43 | DEUTSCHE BANK AG\ | 23,801 | 640,000 | 0.18% | ||
| 44 | A.R.T. Advisors, LLC | 20,385 | 550,000 | 0.15% | ||
| 45 | BAKER BROS. ADVISORS LP | 19,823 | 535,000 | 0.15% | ||
| 46 | DEERE & CO | 19,354 | 523,000 | 0.14% | ||
| 47 | TD ASSET MANAGEMENT INC | 19,200 | 518,000 | 0.14% | ||
| 48 | CREDIT SUISSE AG/ | 19,037 | 514,000 | 0.14% | ||
| 49 | ProShare Advisors LLC | 17,974 | 485,000 | 0.13% | ||
| 50 | CITADEL ADVISORS LLC | 17,471 | 472,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
