| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,655,618 | 386,590,000 | 48.85% | ||
| 2 | BAILLIE GIFFORD & CO | 1,864,206 | 52,775,000 | 6.67% | ||
| 3 | NORTH TIDE CAPITAL, LLC | 1,500,000 | 42,465,000 | 5.37% | ||
| 4 | FMR LLC | 1,405,648 | 39,794,000 | 5.03% | ||
| 5 | Champlain Investment Partners, LLC | 1,234,780 | 34,957,000 | 4.42% | ||
| 6 | VANGUARD GROUP INC | 973,860 | 27,570,000 | 3.48% | ||
| 7 | TPG Group Holdings (SBS) Advisors, Inc. | 910,273 | 25,770,000 | 3.26% | ||
| 8 | BlackRock Fund Advisors | 743,935 | 21,061,000 | 2.66% | ||
| 9 | STATE STREET CORP | 613,889 | 17,377,000 | 2.20% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 554,141 | 15,688,000 | 1.98% | ||
| 11 | IRONBRIDGE CAPITAL MANAGEMENT LP | 454,085 | 12,855,000 | 1.62% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 452,440 | 12,809,000 | 1.62% | ||
| 13 | Murphy Michael R | 291,292 | 8,246,000 | 1.04% | ||
| 14 | Mitsubishi UFJ Trust & Banking Corp | 237,720 | 6,730,000 | 0.85% | ||
| 15 | BLACKROCK ADVISORS LLC | 225,371 | 6,381,000 | 0.81% | ||
| 16 | NORTHERN TRUST CORP | 224,131 | 6,345,000 | 0.80% | ||
| 17 | NORGES BANK | 201,729 | 5,711,000 | 0.72% | ||
| 18 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 183,150 | 5,185,000 | 0.66% | ||
| 19 | GOLDMAN SACHS GROUP INC | 141,065 | 3,993,000 | 0.50% | ||
| 20 | TEACHERS ADVISORS, LLC | 114,961 | 3,255,000 | 0.41% | ||
| 21 | Tributary Capital Management, LLC | 111,244 | 3,149,000 | 0.40% | ||
| 22 | MORGAN STANLEY | 110,108 | 3,118,000 | 0.39% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 97,512 | 2,760,000 | 0.35% | ||
| 24 | Bank of New York Mellon Corp | 93,256 | 2,640,000 | 0.33% | ||
| 25 | GOLDMAN SACHS GROUP INC | 90,500 | 2,562,000 | 0.32% | Put | |
| 26 | PICTET ASSET MANAGEMENT LTD | 82,600 | 2,338,000 | 0.30% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,223 | 2,186,000 | 0.28% | ||
| 28 | PDT Partners, LLC | 72,842 | 2,062,000 | 0.26% | ||
| 29 | OPPENHEIMER & CO INC | 63,893 | 1,808,000 | 0.23% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,279 | 1,763,000 | 0.22% | ||
| 31 | BlackRock Investment Management, LLC | 58,907 | 1,668,000 | 0.21% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,938 | 1,556,000 | 0.20% | ||
| 33 | CATAPULT CAPITAL MANAGEMENT LLC | 51,627 | 1,462,000 | 0.18% | ||
| 34 | WELLS FARGO & COMPANY/MN | 51,475 | 1,457,000 | 0.18% | ||
| 35 | GOLDMAN SACHS GROUP INC | 50,000 | 1,416,000 | 0.18% | Call | |
| 36 | JACOBS LEVY EQUITY MANAGEMENT, INC | 43,803 | 1,240,000 | 0.16% | ||
| 37 | GSA CAPITAL PARTNERS LLP | 42,732 | 1,210,000 | 0.15% | ||
| 38 | Motley Fool Asset Management LLC | 36,179 | 1,139,000 | 0.14% | ||
| 39 | CITADEL ADVISORS LLC | 37,743 | 1,069,000 | 0.14% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 35,445 | 1,003,000 | 0.13% | ||
| 41 | ROYCE & ASSOCIATES LP | 33,000 | 934,000 | 0.12% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,772 | 871,000 | 0.11% | ||
| 43 | BLAIR WILLIAM & CO/IL | 27,910 | 790,000 | 0.10% | ||
| 44 | STONEBRIDGE CAPITAL MANAGEMENT INC | 27,180 | 769,000 | 0.10% | ||
| 45 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,531 | 751,000 | 0.09% | ||
| 46 | STRS OHIO | 25,100 | 711,000 | 0.09% | ||
| 47 | Spark Investment Management LLC | 24,500 | 693,000 | 0.09% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,286 | 659,000 | 0.08% | ||
| 49 | ProShare Advisors LLC | 22,877 | 648,000 | 0.08% | ||
| 50 | TWO SIGMA ADVISERS, LP | 22,220 | 629,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
