| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,656,318 | 436,592,000 | 45.46% | ||
| 2 | Camber Capital Management LP | 2,150,000 | 68,736,000 | 7.16% | ||
| 3 | BAILLIE GIFFORD & CO | 1,848,047 | 59,082,000 | 6.15% | ||
| 4 | NORTH TIDE CAPITAL, LLC | 1,500,000 | 47,955,000 | 4.99% | ||
| 5 | Champlain Investment Partners, LLC | 1,217,175 | 38,913,000 | 4.05% | ||
| 6 | FMR LLC | 1,072,851 | 34,299,000 | 3.57% | ||
| 7 | VANGUARD GROUP INC | 978,179 | 31,273,000 | 3.26% | ||
| 8 | BlackRock Fund Advisors | 800,501 | 25,592,000 | 2.66% | ||
| 9 | STATE STREET CORP | 675,198 | 21,587,000 | 2.25% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 587,193 | 18,773,000 | 1.95% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 557,114 | 17,811,000 | 1.85% | ||
| 12 | BLACKROCK ADVISORS LLC | 479,292 | 15,322,000 | 1.60% | ||
| 13 | IRONBRIDGE CAPITAL MANAGEMENT LP | 440,410 | 14,080,000 | 1.47% | ||
| 14 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 8,321,000 | 0.87% | ||
| 15 | NORTHERN TRUST CORP | 207,935 | 6,647,000 | 0.69% | ||
| 16 | Mitsubishi UFJ Trust & Banking Corp | 201,620 | 6,446,000 | 0.67% | ||
| 17 | NORGES BANK | 198,554 | 6,347,000 | 0.66% | ||
| 18 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 183,150 | 5,855,000 | 0.61% | ||
| 19 | MORGAN STANLEY | 160,074 | 5,118,000 | 0.53% | ||
| 20 | BlackRock Group LTD | 153,647 | 4,912,000 | 0.51% | ||
| 21 | Tributary Capital Management, LLC | 150,896 | 4,824,000 | 0.50% | ||
| 22 | GOLDMAN SACHS GROUP INC | 146,120 | 4,671,000 | 0.49% | ||
| 23 | TEACHERS ADVISORS, LLC | 123,161 | 3,937,000 | 0.41% | ||
| 24 | JPMORGAN CHASE & CO | 120,275 | 3,845,000 | 0.40% | ||
| 25 | Candriam S.C.A. | 120,000 | 3,836,000 | 0.40% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 104,577 | 3,343,000 | 0.35% | ||
| 27 | Bank of New York Mellon Corp | 90,517 | 2,894,000 | 0.30% | ||
| 28 | PICTET ASSET MANAGEMENT LTD | 79,700 | 2,548,000 | 0.27% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,223 | 2,501,000 | 0.26% | ||
| 30 | PDT Partners, LLC | 77,542 | 2,479,000 | 0.26% | ||
| 31 | BlackRock Investment Management, LLC | 74,296 | 2,375,000 | 0.25% | ||
| 32 | Motley Fool Wealth Management, LLC | 72,732 | 2,325,000 | 0.24% | ||
| 33 | Motley Fool Asset Management LLC | 71,935 | 2,300,000 | 0.24% | ||
| 34 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 70,900 | 2,266,000 | 0.24% | ||
| 35 | GSA CAPITAL PARTNERS LLP | 64,217 | 2,053,000 | 0.21% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 58,241 | 1,862,000 | 0.19% | ||
| 37 | BlackRock Finance, Inc. | 56,972 | 1,822,000 | 0.19% | ||
| 38 | OPPENHEIMER & CO INC | 56,893 | 1,819,000 | 0.19% | ||
| 39 | TWO SIGMA INVESTMENTS, LP | 53,661 | 1,716,000 | 0.18% | ||
| 40 | Spark Investment Management LLC | 51,100 | 1,633,000 | 0.17% | ||
| 41 | WELLS FARGO & COMPANY/MN | 50,820 | 1,625,000 | 0.17% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,426 | 1,581,000 | 0.16% | ||
| 43 | CITADEL ADVISORS LLC | 45,969 | 1,470,000 | 0.15% | ||
| 44 | JACOBS LEVY EQUITY MANAGEMENT, INC | 42,893 | 1,371,000 | 0.14% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 35,445 | 1,133,000 | 0.12% | ||
| 46 | CATAPULT CAPITAL MANAGEMENT LLC | 35,000 | 1,119,000 | 0.12% | ||
| 47 | OXFORD ASSET MANAGEMENT LLP | 32,692 | 1,064,000 | 0.11% | ||
| 48 | ROYCE & ASSOCIATES LP | 33,000 | 1,055,000 | 0.11% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,904 | 988,000 | 0.10% | ||
| 50 | TWO SIGMA ADVISERS, LP | 30,620 | 979,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
