| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,657,598 | 379,545,000 | 45.97% | ||
| 2 | Camber Capital Management LP | 2,100,000 | 58,359,000 | 7.07% | ||
| 3 | BAILLIE GIFFORD & CO | 1,570,368 | 43,641,000 | 5.29% | ||
| 4 | STATE STREET CORP | 1,243,703 | 34,564,000 | 4.19% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,183,000 | 32,876,000 | 3.98% | ||
| 6 | VANGUARD GROUP INC | 1,179,148 | 32,768,000 | 3.97% | ||
| 7 | BlackRock Fund Advisors | 833,783 | 23,171,000 | 2.81% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 627,528 | 17,439,000 | 2.11% | ||
| 9 | FMR LLC | 602,080 | 16,732,000 | 2.03% | ||
| 10 | BLACKROCK ADVISORS LLC | 554,671 | 15,414,000 | 1.87% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 439,879 | 12,224,000 | 1.48% | ||
| 12 | IRONBRIDGE CAPITAL MANAGEMENT LP | 356,746 | 9,914,000 | 1.20% | ||
| 13 | GOLDMAN SACHS GROUP INC | 269,689 | 7,494,000 | 0.91% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 267,200 | 7,425,000 | 0.90% | ||
| 15 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 7,233,000 | 0.88% | ||
| 16 | JPMORGAN CHASE & CO | 203,870 | 5,665,000 | 0.69% | ||
| 17 | Tributary Capital Management, LLC | 201,490 | 5,599,000 | 0.68% | ||
| 18 | NORTHERN TRUST CORP | 199,445 | 5,543,000 | 0.67% | ||
| 19 | BlackRock Group LTD | 187,211 | 5,202,000 | 0.63% | ||
| 20 | Candriam S.C.A. | 184,000 | 5,113,000 | 0.62% | ||
| 21 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 183,150 | 5,090,000 | 0.62% | ||
| 22 | NORGES BANK | 178,270 | 4,954,000 | 0.60% | ||
| 23 | Mitsubishi UFJ Trust & Banking Corp | 166,660 | 4,631,000 | 0.56% | ||
| 24 | Motley Fool Wealth Management, LLC | 143,757 | 3,995,000 | 0.48% | ||
| 25 | GSA CAPITAL PARTNERS LLP | 143,550 | 3,989,000 | 0.48% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 141,557 | 3,933,000 | 0.48% | ||
| 27 | OPPENHEIMER & CO INC | 131,049 | 3,642,000 | 0.44% | ||
| 28 | MORGAN STANLEY | 130,827 | 3,636,000 | 0.44% | ||
| 29 | PDT Partners, LLC | 128,727 | 3,577,000 | 0.43% | ||
| 30 | TFS CAPITAL LLC | 102,481 | 2,848,000 | 0.34% | ||
| 31 | Motley Fool Asset Management LLC | 101,935 | 2,833,000 | 0.34% | ||
| 32 | Bank of New York Mellon Corp | 99,376 | 2,761,000 | 0.33% | ||
| 33 | BlackRock Investment Management, LLC | 88,940 | 2,472,000 | 0.30% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,223 | 2,146,000 | 0.26% | ||
| 35 | CREDIT SUISSE AG/ | 75,649 | 2,102,000 | 0.25% | ||
| 36 | CORRADO ADVISORS, LLC | 75,290 | 2,092,000 | 0.25% | ||
| 37 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 75,000 | 2,085,000 | 0.25% | ||
| 38 | DEUTSCHE BANK AG\ | 74,821 | 2,077,000 | 0.25% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 60,596 | 1,684,000 | 0.20% | ||
| 40 | EMORY UNIVERSITY | 54,966 | 1,528,000 | 0.19% | ||
| 41 | MACQUARIE GROUP LTD | 55,000 | 1,528,000 | 0.19% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 54,486 | 1,514,000 | 0.18% | ||
| 43 | WELLS FARGO & COMPANY/MN | 54,309 | 1,510,000 | 0.18% | ||
| 44 | BlackRock Finance, Inc. | 54,072 | 1,502,000 | 0.18% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,156 | 1,478,000 | 0.18% | ||
| 46 | Spark Investment Management LLC | 51,100 | 1,419,000 | 0.17% | ||
| 47 | JACOBS LEVY EQUITY MANAGEMENT, INC | 50,693 | 1,409,000 | 0.17% | ||
| 48 | D. E. Shaw & Co., Inc. | 47,337 | 1,315,000 | 0.16% | ||
| 49 | CITADEL ADVISORS LLC | 38,744 | 1,076,000 | 0.13% | ||
| 50 | GOLDMAN SACHS GROUP INC | 37,000 | 1,028,000 | 0.12% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
