| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,659,832 | 338,354,000 | 45.56% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 60,887,000 | 8.20% | ||
| 3 | BAILLIE GIFFORD & CO | 1,337,089 | 33,118,000 | 4.46% | ||
| 4 | VANGUARD GROUP INC | 1,326,295 | 32,852,000 | 4.42% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,175,155 | 29,109,000 | 3.92% | ||
| 6 | BlackRock Fund Advisors | 848,433 | 21,016,000 | 2.83% | ||
| 7 | LOOMIS SAYLES & CO L P | 631,380 | 15,639,000 | 2.11% | ||
| 8 | ACADIAN ASSET MANAGEMENT LLC | 547,297 | 13,557,000 | 1.83% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 528,113 | 13,081,000 | 1.76% | ||
| 10 | FMR LLC | 525,148 | 13,008,000 | 1.75% | ||
| 11 | BLACKROCK ADVISORS LLC | 520,967 | 12,904,000 | 1.74% | ||
| 12 | STATE STREET CORP | 502,439 | 12,443,000 | 1.68% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 446,021 | 11,048,000 | 1.49% | ||
| 14 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 6,447,000 | 0.87% | ||
| 15 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 260,181 | 6,445,000 | 0.87% | ||
| 16 | NORTHERN TRUST CORP | 226,772 | 5,617,000 | 0.76% | ||
| 17 | Cortina Asset Management, LLC | 222,463 | 5,510,000 | 0.74% | ||
| 18 | Tributary Capital Management, LLC | 184,586 | 4,572,000 | 0.62% | ||
| 19 | BlackRock Group LTD | 180,781 | 4,478,000 | 0.60% | ||
| 20 | Mitsubishi UFJ Trust & Banking Corp | 161,200 | 3,993,000 | 0.54% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 158,078 | 3,915,000 | 0.53% | ||
| 22 | Visium Asset Management, LP | 152,100 | 3,768,000 | 0.51% | ||
| 23 | LORD, ABBETT & CO. LLC | 150,060 | 3,717,000 | 0.50% | ||
| 24 | OPPENHEIMER & CO INC | 146,749 | 3,635,000 | 0.49% | ||
| 25 | TWO SIGMA INVESTMENTS, LP | 143,866 | 3,564,000 | 0.48% | ||
| 26 | Motley Fool Asset Management LLC | 131,935 | 3,268,000 | 0.44% | ||
| 27 | Motley Fool Wealth Management, LLC | 116,396 | 2,883,000 | 0.39% | ||
| 28 | Numeric Investors LLC | 113,899 | 2,821,000 | 0.38% | ||
| 29 | GSA CAPITAL PARTNERS LLP | 106,151 | 2,629,000 | 0.35% | ||
| 30 | MORGAN STANLEY | 103,454 | 2,563,000 | 0.35% | ||
| 31 | RUSSELL FRANK CO/ | 102,387 | 2,536,000 | 0.34% | ||
| 32 | TWO SIGMA ADVISERS, LP | 99,920 | 2,475,000 | 0.33% | ||
| 33 | Candriam S.C.A. | 100,000 | 2,464,000 | 0.33% | ||
| 34 | Spark Investment Management LLC | 96,101 | 2,380,000 | 0.32% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 92,300 | 2,286,000 | 0.31% | ||
| 36 | BlackRock Investment Management, LLC | 90,258 | 2,236,000 | 0.30% | ||
| 37 | Bank of New York Mellon Corp | 86,648 | 2,147,000 | 0.29% | ||
| 38 | TFS CAPITAL LLC | 85,095 | 2,108,000 | 0.28% | ||
| 39 | NORGES BANK | 84,092 | 2,083,000 | 0.28% | ||
| 40 | GOLDMAN SACHS GROUP INC | 81,866 | 2,028,000 | 0.27% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 78,140 | 1,936,000 | 0.26% | ||
| 42 | ROYCE & ASSOCIATES LP | 76,500 | 1,895,000 | 0.26% | ||
| 43 | DEUTSCHE BANK AG\ | 68,355 | 1,691,000 | 0.23% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 68,016 | 1,685,000 | 0.23% | ||
| 45 | WELLS FARGO & COMPANY/MN | 59,411 | 1,471,000 | 0.20% | ||
| 46 | D. E. Shaw & Co., Inc. | 57,639 | 1,428,000 | 0.19% | ||
| 47 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 57,461 | 1,423,000 | 0.19% | ||
| 48 | CASDIN CAPITAL, LLC | 55,000 | 1,362,000 | 0.18% | ||
| 49 | MACQUARIE GROUP LTD | 55,000 | 1,362,000 | 0.18% | ||
| 50 | JACOBS LEVY EQUITY MANAGEMENT, INC | 48,903 | 1,211,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
