| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,658,328 | 289,011,000 | 44.79% | ||
| 2 | Camber Capital Management LP | 2,450,000 | 51,842,000 | 8.03% | ||
| 3 | BAILLIE GIFFORD & CO | 1,429,209 | 30,242,000 | 4.69% | ||
| 4 | VANGUARD GROUP INC | 1,247,047 | 26,388,000 | 4.09% | ||
| 5 | STATE STREET CORP | 1,242,889 | 26,301,000 | 4.08% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,093,516 | 23,139,000 | 3.59% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 993,528 | 21,023,000 | 3.26% | ||
| 8 | BlackRock Fund Advisors | 882,888 | 18,682,000 | 2.90% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 587,927 | 12,441,000 | 1.93% | ||
| 10 | FMR LLC | 570,348 | 12,069,000 | 1.87% | ||
| 11 | BLACKROCK ADVISORS LLC | 548,214 | 11,601,000 | 1.80% | ||
| 12 | DECADE CAPITAL MANAGEMENT LLC | 419,274 | 8,872,000 | 1.37% | ||
| 13 | IRONBRIDGE CAPITAL MANAGEMENT LP | 349,544 | 7,396,000 | 1.15% | ||
| 14 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 5,507,000 | 0.85% | ||
| 15 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 260,181 | 5,505,000 | 0.85% | ||
| 16 | Tributary Capital Management, LLC | 238,797 | 5,053,000 | 0.78% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 233,800 | 4,947,000 | 0.77% | ||
| 18 | NORTHERN TRUST CORP | 216,823 | 4,588,000 | 0.71% | ||
| 19 | MORGAN STANLEY | 206,486 | 4,369,000 | 0.68% | ||
| 20 | BlackRock Group LTD | 188,619 | 3,992,000 | 0.62% | ||
| 21 | TFS CAPITAL LLC | 183,744 | 3,888,000 | 0.60% | ||
| 22 | Candriam S.C.A. | 174,400 | 3,690,000 | 0.57% | ||
| 23 | Mitsubishi UFJ Trust & Banking Corp | 166,660 | 3,527,000 | 0.55% | ||
| 24 | OPPENHEIMER & CO INC | 146,379 | 3,097,000 | 0.48% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 144,552 | 3,058,000 | 0.47% | ||
| 26 | NORGES BANK | 139,627 | 2,955,000 | 0.46% | ||
| 27 | Motley Fool Asset Management LLC | 131,935 | 2,792,000 | 0.43% | ||
| 28 | GOLDMAN SACHS GROUP INC | 113,756 | 2,407,000 | 0.37% | ||
| 29 | GSA CAPITAL PARTNERS LLP | 104,748 | 2,216,000 | 0.34% | ||
| 30 | BlackRock Investment Management, LLC | 88,881 | 1,881,000 | 0.29% | ||
| 31 | Bank of New York Mellon Corp | 83,019 | 1,756,000 | 0.27% | ||
| 32 | Motley Fool Wealth Management, LLC | 82,858 | 1,753,000 | 0.27% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 77,200 | 1,634,000 | 0.25% | ||
| 34 | PDT Partners, LLC | 75,129 | 1,590,000 | 0.25% | ||
| 35 | JACOBS LEVY EQUITY MANAGEMENT, INC | 67,473 | 1,428,000 | 0.22% | ||
| 36 | CORRADO ADVISORS, LLC | 66,665 | 1,411,000 | 0.22% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 61,381 | 1,299,000 | 0.20% | ||
| 38 | EMORY UNIVERSITY | 60,828 | 1,287,000 | 0.20% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 58,860 | 1,245,000 | 0.19% | ||
| 40 | WELLS FARGO & COMPANY/MN | 56,908 | 1,204,000 | 0.19% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 56,457 | 1,195,000 | 0.19% | ||
| 42 | MACQUARIE GROUP LTD | 55,000 | 1,164,000 | 0.18% | ||
| 43 | BlackRock Finance, Inc. | 54,072 | 1,144,000 | 0.18% | ||
| 44 | Spark Investment Management LLC | 51,100 | 1,080,000 | 0.17% | ||
| 45 | D. E. Shaw & Co., Inc. | 49,737 | 1,052,000 | 0.16% | ||
| 46 | Connor, Clark & Lunn Investment Management Ltd. | 46,500 | 984,000 | 0.15% | ||
| 47 | GOLDMAN SACHS GROUP INC | 40,000 | 846,000 | 0.13% | Call | |
| 48 | GOLDMAN SACHS GROUP INC | 40,000 | 846,000 | 0.13% | Put | |
| 49 | TWO SIGMA ADVISERS, LP | 37,120 | 792,000 | 0.12% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 36,485 | 772,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
