| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,770,302 | 398,237,000 | 45.78% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 71,088,000 | 8.17% | ||
| 3 | VANGUARD GROUP INC | 1,391,784 | 40,250,000 | 4.63% | ||
| 4 | BlackRock Fund Advisors | 914,017 | 26,433,000 | 3.04% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 729,935 | 21,110,000 | 2.43% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 647,646 | 18,730,000 | 2.15% | ||
| 7 | LOOMIS SAYLES & CO L P | 557,770 | 16,131,000 | 1.85% | ||
| 8 | BAILLIE GIFFORD & CO | 548,376 | 15,860,000 | 1.82% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 547,600 | 15,837,000 | 1.82% | ||
| 10 | STATE STREET CORP | 511,144 | 14,781,000 | 1.70% | ||
| 11 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 468,556 | 13,551,000 | 1.56% | ||
| 12 | BLACKROCK ADVISORS LLC | 381,194 | 11,024,000 | 1.27% | ||
| 13 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 372,914 | 10,785,000 | 1.24% | ||
| 14 | FMR LLC | 338,248 | 9,782,000 | 1.12% | ||
| 15 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 317,240 | 9,175,000 | 1.05% | ||
| 16 | EAGLE ASSET MANAGEMENT INC | 291,066 | 8,417,000 | 0.97% | ||
| 17 | ACADIAN ASSET MANAGEMENT LLC | 270,002 | 7,809,000 | 0.90% | ||
| 18 | NORTHERN TRUST CORP | 236,887 | 6,851,000 | 0.79% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 230,242 | 6,659,000 | 0.77% | ||
| 20 | Tributary Capital Management, LLC | 221,354 | 6,402,000 | 0.74% | ||
| 21 | Spark Investment Management LLC | 211,600 | 6,119,000 | 0.70% | ||
| 22 | PRUDENTIAL FINANCIAL INC | 184,090 | 5,324,000 | 0.61% | ||
| 23 | LORD, ABBETT & CO. LLC | 182,562 | 5,279,000 | 0.61% | ||
| 24 | GOLDMAN SACHS GROUP INC | 171,218 | 4,952,000 | 0.57% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 165,437 | 4,783,000 | 0.55% | ||
| 26 | TWO SIGMA ADVISERS, LP | 156,319 | 4,521,000 | 0.52% | ||
| 27 | Mitsubishi UFJ Trust & Banking Corp | 152,520 | 4,411,000 | 0.51% | ||
| 28 | NORGES BANK | 154,668 | 4,272,000 | 0.49% | ||
| 29 | BlackRock Group LTD | 144,396 | 4,177,000 | 0.48% | ||
| 30 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 139,361 | 4,029,000 | 0.46% | ||
| 31 | OPPENHEIMER & CO INC | 138,749 | 4,013,000 | 0.46% | ||
| 32 | Motley Fool Asset Management LLC | 131,935 | 3,816,000 | 0.44% | ||
| 33 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 128,900 | 3,728,000 | 0.43% | ||
| 34 | Motley Fool Wealth Management, LLC | 119,327 | 3,451,000 | 0.40% | ||
| 35 | Numeric Investors LLC | 114,184 | 3,302,000 | 0.38% | ||
| 36 | Laurion Capital Management LP | 94,084 | 2,721,000 | 0.31% | ||
| 37 | CASDIN CAPITAL, LLC | 90,000 | 2,603,000 | 0.30% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 89,625 | 2,592,000 | 0.30% | ||
| 39 | BlackRock Investment Management, LLC | 87,540 | 2,532,000 | 0.29% | ||
| 40 | Bank of New York Mellon Corp | 86,038 | 2,489,000 | 0.29% | ||
| 41 | D. E. Shaw & Co., Inc. | 81,515 | 2,357,000 | 0.27% | ||
| 42 | Candriam S.C.A. | 79,000 | 2,285,000 | 0.26% | ||
| 43 | Ghost Tree Capital, LLC | 75,000 | 2,169,000 | 0.25% | ||
| 44 | PANAGORA ASSET MANAGEMENT INC | 72,920 | 2,109,000 | 0.24% | ||
| 45 | ACUTA CAPITAL PARTNERS, LLC | 72,100 | 2,085,000 | 0.24% | ||
| 46 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 70,708 | 2,044,000 | 0.23% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 69,396 | 2,007,000 | 0.23% | ||
| 48 | ROYCE & ASSOCIATES LP | 68,500 | 1,981,000 | 0.23% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 67,700 | 1,958,000 | 0.23% | ||
| 50 | SECOR Capital Advisors, LP | 66,536 | 1,924,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
