| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,654,150 | 359,650,000 | 48.50% | ||
| 2 | FMR LLC | 2,817,709 | 74,218,000 | 10.01% | ||
| 3 | BAILLIE GIFFORD & CO | 1,337,715 | 35,235,000 | 4.75% | ||
| 4 | Champlain Investment Partners, LLC | 1,250,910 | 32,949,000 | 4.44% | ||
| 5 | VANGUARD GROUP INC | 952,999 | 25,102,000 | 3.39% | ||
| 6 | TPG Group Holdings (SBS) Advisors, Inc. | 910,273 | 23,977,000 | 3.23% | ||
| 7 | STATE STREET CORP | 882,981 | 23,255,000 | 3.14% | ||
| 8 | BlackRock Fund Advisors | 795,858 | 20,963,000 | 2.83% | ||
| 9 | IRONBRIDGE CAPITAL MANAGEMENT LP | 579,440 | 15,262,000 | 2.06% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 565,755 | 14,902,000 | 2.01% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 369,975 | 9,745,000 | 1.31% | ||
| 12 | Visium Asset Management, LP | 306,958 | 8,086,000 | 1.09% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 304,900 | 8,031,000 | 1.08% | Put | |
| 14 | Mitsubishi UFJ Trust & Banking Corp | 271,370 | 7,148,000 | 0.96% | ||
| 15 | NORTHERN TRUST CORP | 244,531 | 6,440,000 | 0.87% | ||
| 16 | CITADEL ADVISORS LLC | 206,406 | 5,437,000 | 0.73% | ||
| 17 | NORGES BANK | 201,729 | 5,313,000 | 0.72% | ||
| 18 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 145,800 | 3,840,000 | 0.52% | ||
| 19 | TEACHERS ADVISORS, LLC | 116,407 | 3,066,000 | 0.41% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 108,555 | 2,859,000 | 0.39% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 108,201 | 2,850,000 | 0.38% | ||
| 22 | DEUTSCHE BANK AG\ | 101,755 | 2,678,000 | 0.36% | ||
| 23 | NORTH TIDE CAPITAL, LLC | 100,000 | 2,634,000 | 0.36% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 94,726 | 2,495,000 | 0.34% | ||
| 25 | PICTET ASSET MANAGEMENT LTD | 94,700 | 2,494,000 | 0.34% | ||
| 26 | Bank of New York Mellon Corp | 88,424 | 2,329,000 | 0.31% | ||
| 27 | CREDIT SUISSE AG/ | 83,853 | 2,208,000 | 0.30% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 80,023 | 2,183,000 | 0.29% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,592 | 2,175,000 | 0.29% | ||
| 30 | MORGAN STANLEY | 74,034 | 1,950,000 | 0.26% | ||
| 31 | PDT Partners, LLC | 71,342 | 1,879,000 | 0.25% | ||
| 32 | GOLDMAN SACHS GROUP INC | 68,980 | 1,817,000 | 0.25% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,500 | 1,620,000 | 0.22% | Call | |
| 34 | OPPENHEIMER & CO INC | 60,415 | 1,591,000 | 0.21% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,980 | 1,422,000 | 0.19% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 47,065 | 1,240,000 | 0.17% | ||
| 37 | BlackRock Investment Management, LLC | 46,519 | 1,225,000 | 0.17% | ||
| 38 | WELLS FARGO & COMPANY/MN | 41,864 | 1,102,000 | 0.15% | ||
| 39 | ProShare Advisors LLC | 40,480 | 1,066,000 | 0.14% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 40,140 | 1,057,000 | 0.14% | ||
| 41 | ROYCE & ASSOCIATES LP | 33,000 | 869,000 | 0.12% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,297 | 798,000 | 0.11% | ||
| 43 | PANAGORA ASSET MANAGEMENT INC | 30,170 | 795,000 | 0.11% | ||
| 44 | BLAIR WILLIAM & CO/IL | 28,960 | 762,000 | 0.10% | ||
| 45 | STONEBRIDGE CAPITAL MANAGEMENT INC | 28,750 | 757,000 | 0.10% | ||
| 46 | STRS OHIO | 28,400 | 748,000 | 0.10% | ||
| 47 | MESSNER & SMITH THEME VALUE INVESTMENT MANAGEMENT LTD /CA/ | 26,972 | 711,000 | 0.10% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 25,000 | 659,000 | 0.09% | Put | |
| 49 | Absolute Return Capital, LLC | 23,167 | 610,000 | 0.08% | ||
| 50 | Stanley-Laman Group, Ltd. | 23,101 | 608,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
