| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,770,302 | 404,709,000 | 45.49% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 72,244,000 | 8.12% | ||
| 3 | VANGUARD GROUP INC | 1,437,363 | 42,245,000 | 4.75% | ||
| 4 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,275,338 | 37,482,000 | 4.21% | ||
| 5 | BlackRock Fund Advisors | 1,023,933 | 30,093,000 | 3.38% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 813,051 | 23,896,000 | 2.69% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 699,415 | 20,556,000 | 2.31% | ||
| 8 | RENAISSANCE TECHNOLOGIES LLC | 576,700 | 16,949,000 | 1.91% | ||
| 9 | STATE STREET CORP | 545,119 | 16,024,000 | 1.80% | ||
| 10 | LOOMIS SAYLES & CO L P | 531,171 | 15,611,000 | 1.75% | ||
| 11 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 444,476 | 13,064,000 | 1.47% | ||
| 12 | BLACKROCK ADVISORS LLC | 375,587 | 11,039,000 | 1.24% | ||
| 13 | EAGLE ASSET MANAGEMENT INC | 318,431 | 9,358,000 | 1.05% | ||
| 14 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 317,240 | 9,324,000 | 1.05% | ||
| 15 | FMR LLC | 263,348 | 7,740,000 | 0.87% | ||
| 16 | NORTHERN TRUST CORP | 246,912 | 7,257,000 | 0.82% | ||
| 17 | Tributary Capital Management, LLC | 237,371 | 6,976,000 | 0.78% | ||
| 18 | GOLDMAN SACHS GROUP INC | 212,623 | 6,249,000 | 0.70% | ||
| 19 | TWO SIGMA INVESTMENTS, LP | 205,834 | 6,049,000 | 0.68% | ||
| 20 | PRUDENTIAL FINANCIAL INC | 197,490 | 5,804,000 | 0.65% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 192,289 | 5,650,000 | 0.64% | ||
| 22 | Spark Investment Management LLC | 189,700 | 5,575,000 | 0.63% | ||
| 23 | LORD, ABBETT & CO. LLC | 184,706 | 5,428,000 | 0.61% | ||
| 24 | MORGAN STANLEY | 165,242 | 4,857,000 | 0.55% | ||
| 25 | NORGES BANK | 154,668 | 4,546,000 | 0.51% | ||
| 26 | BlackRock Group LTD | 141,630 | 4,162,000 | 0.47% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 138,545 | 4,072,000 | 0.46% | ||
| 28 | TWO SIGMA ADVISERS, LP | 136,133 | 4,001,000 | 0.45% | ||
| 29 | Mitsubishi UFJ Trust & Banking Corp | 133,360 | 3,919,000 | 0.44% | ||
| 30 | Motley Fool Asset Management LLC | 131,935 | 3,878,000 | 0.44% | ||
| 31 | AMERICAN CENTURY COMPANIES INC | 127,196 | 3,738,000 | 0.42% | ||
| 32 | Motley Fool Wealth Management, LLC | 123,139 | 3,619,000 | 0.41% | ||
| 33 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 122,700 | 3,606,000 | 0.41% | ||
| 34 | OPPENHEIMER & CO INC | 108,749 | 3,196,000 | 0.36% | ||
| 35 | JACOBS LEVY EQUITY MANAGEMENT, INC | 104,670 | 3,076,000 | 0.35% | ||
| 36 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 103,262 | 3,034,000 | 0.34% | ||
| 37 | Bank of New York Mellon Corp | 88,077 | 2,589,000 | 0.29% | ||
| 38 | BlackRock Investment Management, LLC | 87,943 | 2,585,000 | 0.29% | ||
| 39 | Candriam S.C.A. | 87,000 | 2,557,000 | 0.29% | ||
| 40 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 78,904 | 2,318,000 | 0.26% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 69,922 | 2,055,000 | 0.23% | ||
| 42 | BANK OF MONTREAL /CAN/ | 66,467 | 2,023,000 | 0.23% | ||
| 43 | WELLS FARGO & COMPANY/MN | 67,504 | 1,984,000 | 0.22% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,425 | 1,982,000 | 0.22% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 66,200 | 1,946,000 | 0.22% | ||
| 46 | EMORY UNIVERSITY | 64,147 | 1,885,000 | 0.21% | ||
| 47 | CREDIT SUISSE AG/ | 58,197 | 1,710,000 | 0.19% | ||
| 48 | SECOR Capital Advisors, LP | 56,603 | 1,664,000 | 0.19% | ||
| 49 | D. E. Shaw & Co., Inc. | 55,977 | 1,645,000 | 0.18% | ||
| 50 | TFS CAPITAL LLC | 54,058 | 1,589,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
