| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,668,866 | 353,955,000 | 46.02% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 63,652,000 | 8.28% | ||
| 3 | VANGUARD GROUP INC | 1,368,807 | 35,445,000 | 4.61% | ||
| 4 | BAILLIE GIFFORD & CO | 1,120,296 | 29,010,000 | 3.77% | ||
| 5 | BlackRock Fund Advisors | 866,021 | 22,426,000 | 2.92% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 836,285 | 21,656,000 | 2.82% | ||
| 7 | LOOMIS SAYLES & CO L P | 616,495 | 15,964,000 | 2.08% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 583,742 | 15,116,000 | 1.97% | ||
| 9 | FMR LLC | 525,148 | 13,599,000 | 1.77% | ||
| 10 | ACADIAN ASSET MANAGEMENT LLC | 524,904 | 13,590,000 | 1.77% | ||
| 11 | BLACKROCK ADVISORS LLC | 500,556 | 12,962,000 | 1.69% | ||
| 12 | STATE STREET CORP | 464,510 | 12,029,000 | 1.56% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 436,100 | 11,293,000 | 1.47% | ||
| 14 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 317,240 | 8,215,000 | 1.07% | ||
| 15 | Broadfin Capital, LLC | 270,400 | 7,002,000 | 0.91% | ||
| 16 | TPG Group Holdings (SBS) Advisors, Inc. | 260,273 | 6,740,000 | 0.88% | ||
| 17 | NORTHERN TRUST CORP | 237,063 | 6,139,000 | 0.80% | ||
| 18 | Tributary Capital Management, LLC | 206,291 | 5,342,000 | 0.69% | ||
| 19 | Ghost Tree Capital, LLC | 200,000 | 5,179,000 | 0.67% | ||
| 20 | BlackRock Group LTD | 192,069 | 4,972,000 | 0.65% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 161,839 | 4,190,000 | 0.54% | ||
| 22 | LORD, ABBETT & CO. LLC | 157,626 | 4,082,000 | 0.53% | ||
| 23 | Mitsubishi UFJ Trust & Banking Corp | 149,700 | 3,876,000 | 0.50% | ||
| 24 | OPPENHEIMER & CO INC | 141,749 | 3,670,000 | 0.48% | ||
| 25 | TWO SIGMA INVESTMENTS, LP | 141,465 | 3,663,000 | 0.48% | ||
| 26 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 131,961 | 3,417,000 | 0.44% | ||
| 27 | Motley Fool Asset Management LLC | 131,935 | 3,416,000 | 0.44% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,652 | 3,306,000 | 0.43% | ||
| 29 | Motley Fool Wealth Management, LLC | 123,018 | 3,186,000 | 0.41% | ||
| 30 | GOLDMAN SACHS GROUP INC | 112,057 | 2,902,000 | 0.38% | ||
| 31 | Spark Investment Management LLC | 105,200 | 2,724,000 | 0.35% | ||
| 32 | MORGAN STANLEY | 105,036 | 2,720,000 | 0.35% | ||
| 33 | TWO SIGMA ADVISERS, LP | 100,320 | 2,598,000 | 0.34% | ||
| 34 | BlackRock Investment Management, LLC | 93,730 | 2,427,000 | 0.32% | ||
| 35 | Bank of New York Mellon Corp | 88,963 | 2,304,000 | 0.30% | ||
| 36 | ROYCE & ASSOCIATES LP | 88,500 | 2,292,000 | 0.30% | ||
| 37 | PRUDENTIAL FINANCIAL INC | 85,930 | 2,225,000 | 0.29% | ||
| 38 | NORGES BANK | 84,092 | 2,178,000 | 0.28% | ||
| 39 | EMERALD ACQUISITION LTD. | 76,565 | 1,983,000 | 0.26% | ||
| 40 | ASCEND CAPITAL, LLC | 75,000 | 1,942,000 | 0.25% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 72,300 | 1,872,000 | 0.24% | ||
| 42 | D. E. Shaw & Co., Inc. | 72,201 | 1,870,000 | 0.24% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 69,606 | 1,802,000 | 0.23% | ||
| 44 | Candriam S.C.A. | 63,000 | 1,631,000 | 0.21% | ||
| 45 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 62,000 | 1,605,000 | 0.21% | ||
| 46 | TFS CAPITAL LLC | 61,773 | 1,600,000 | 0.21% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 60,545 | 1,568,000 | 0.20% | ||
| 48 | WELLS FARGO & COMPANY/MN | 60,473 | 1,566,000 | 0.20% | ||
| 49 | SECOR Capital Advisors, LP | 57,893 | 1,500,000 | 0.20% | ||
| 50 | MACQUARIE GROUP LTD | 55,000 | 1,424,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
