| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,226,458 | 94,305,000 | 17.33% | ||
| 2 | Palo Alto Investors LP | 3,892,199 | 50,793,000 | 9.33% | ||
| 3 | Point72 Asset Management, L.P. | 2,569,636 | 33,534,000 | 6.16% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,080,160 | 27,146,000 | 4.99% | ||
| 5 | STATE STREET CORP | 1,826,471 | 23,837,000 | 4.38% | ||
| 6 | JPMORGAN CHASE & CO | 1,692,811 | 22,091,000 | 4.06% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 1,625,323 | 21,210,000 | 3.90% | ||
| 8 | Tourbillon Capital Partners, L.P. | 1,526,343 | 19,919,000 | 3.66% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,318,191 | 17,202,000 | 3.16% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 1,198,360 | 15,639,000 | 2.87% | ||
| 11 | VANGUARD GROUP INC | 1,185,742 | 15,474,000 | 2.84% | ||
| 12 | BlackRock Fund Advisors | 1,177,493 | 15,366,000 | 2.82% | ||
| 13 | BAKER BROS. ADVISORS LP | 1,107,850 | 14,457,000 | 2.66% | ||
| 14 | Redmile Group, LLC | 1,090,624 | 14,233,000 | 2.61% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 1,016,044 | 13,259,000 | 2.44% | ||
| 16 | UBS AG | 907,496 | 11,843,000 | 2.18% | ||
| 17 | JENNISON ASSOCIATES LLC | 800,438 | 10,446,000 | 1.92% | ||
| 18 | AMERIPRISE FINANCIAL INC | 753,315 | 9,830,000 | 1.81% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 663,300 | 8,656,000 | 1.59% | ||
| 20 | PERCEPTIVE ADVISORS LLC | 600,000 | 7,830,000 | 1.44% | ||
| 21 | NORTHERN TRUST CORP | 573,700 | 7,486,000 | 1.38% | ||
| 22 | DEUTSCHE BANK AG\ | 422,640 | 5,513,000 | 1.01% | ||
| 23 | STIFEL FINANCIAL CORP | 402,062 | 5,247,000 | 0.96% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 401,000 | 5,233,000 | 0.96% | ||
| 25 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,000 | 5,220,000 | 0.96% | ||
| 26 | Invesco Ltd. | 378,251 | 4,936,000 | 0.91% | ||
| 27 | Bank of New York Mellon Corp | 315,985 | 4,124,000 | 0.76% | ||
| 28 | TEACHERS ADVISORS, LLC | 280,286 | 3,658,000 | 0.67% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 256,761 | 3,350,000 | 0.62% | ||
| 30 | PUTNAM INVESTMENTS LLC | 241,059 | 3,146,000 | 0.58% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 216,007 | 2,819,000 | 0.52% | ||
| 32 | Asset Management One Co., Ltd. | 197,334 | 2,665,000 | 0.49% | ||
| 33 | Jefferies Group LLC | 200,000 | 2,610,000 | 0.48% | Call | |
| 34 | Lombard Odier Asset Management (USA) Corp | 199,895 | 2,609,000 | 0.48% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 173,377 | 2,262,000 | 0.42% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 170,000 | 2,219,000 | 0.41% | ||
| 37 | Nicholas Investment Partners, LP | 165,473 | 2,159,000 | 0.40% | ||
| 38 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 156,200 | 2,039,000 | 0.37% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 144,400 | 1,884,000 | 0.35% | Call | |
| 40 | BlackRock Investment Management, LLC | 144,008 | 1,879,000 | 0.35% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 131,848 | 1,721,000 | 0.32% | ||
| 42 | PICTET ASSET MANAGEMENT LTD | 104,200 | 1,360,000 | 0.25% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 91,538 | 1,195,000 | 0.22% | ||
| 44 | EVENTIDE ASSET MANAGEMENT, LLC | 88,600 | 1,156,000 | 0.21% | ||
| 45 | Allianz Asset Management GmbH | 87,685 | 1,144,000 | 0.21% | ||
| 46 | Informed Momentum Co LLC | 83,453 | 1,089,000 | 0.20% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 78,600 | 1,026,000 | 0.19% | ||
| 48 | CITADEL ADVISORS LLC | 78,372 | 1,023,000 | 0.19% | ||
| 49 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 77,573 | 1,012,000 | 0.19% | ||
| 50 | HBK INVESTMENTS L P | 69,502 | 907,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
