| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,506,925 | 139,007,000 | 18.09% | ||
| 2 | FMR LLC | 9,281,685 | 122,796,000 | 15.98% | ||
| 3 | Palo Alto Investors LP | 5,446,516 | 72,057,000 | 9.38% | ||
| 4 | ORBIMED ADVISORS LLC | 5,301,805 | 70,143,000 | 9.13% | ||
| 5 | VANGUARD GROUP INC | 3,607,951 | 47,734,000 | 6.21% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,855,576 | 37,784,000 | 4.92% | ||
| 7 | BlackRock Fund Advisors | 2,705,488 | 35,794,000 | 4.66% | ||
| 8 | JPMORGAN CHASE & CO | 1,565,157 | 20,707,000 | 2.69% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,562,321 | 20,670,000 | 2.69% | ||
| 10 | STATE STREET CORP | 1,431,292 | 18,935,000 | 2.46% | ||
| 11 | EMERALD ADVISERS, LLC | 1,340,320 | 17,732,000 | 2.31% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,167,439 | 15,445,000 | 2.01% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 960,841 | 12,712,000 | 1.65% | ||
| 14 | NORTHERN TRUST CORP | 784,294 | 10,376,000 | 1.35% | ||
| 15 | MORGAN STANLEY | 531,102 | 7,027,000 | 0.91% | ||
| 16 | DEUTSCHE BANK AG\ | 476,045 | 6,295,000 | 0.82% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 470,836 | 6,229,000 | 0.81% | ||
| 18 | Rock Springs Capital Management LP | 468,000 | 6,192,000 | 0.81% | ||
| 19 | Invesco Ltd. | 457,652 | 6,055,000 | 0.79% | ||
| 20 | AXA S.A. | 456,280 | 6,037,000 | 0.79% | ||
| 21 | BAKER BROS. ADVISORS LP | 400,000 | 5,292,000 | 0.69% | ||
| 22 | TEACHERS ADVISORS, LLC | 390,648 | 5,168,000 | 0.67% | ||
| 23 | NEXTHERA CAPITAL LP | 322,044 | 4,261,000 | 0.55% | ||
| 24 | Bank of New York Mellon Corp | 302,158 | 3,998,000 | 0.52% | ||
| 25 | STATE OF MICHIGAN RETIREMENT SYSTEM | 300,000 | 3,969,000 | 0.52% | ||
| 26 | GOLDMAN SACHS GROUP INC | 279,365 | 3,696,000 | 0.48% | ||
| 27 | NORGES BANK | 274,782 | 3,635,000 | 0.47% | ||
| 28 | CITIGROUP INC | 266,169 | 3,521,000 | 0.46% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 264,836 | 3,504,000 | 0.46% | ||
| 30 | TD ASSET MANAGEMENT INC | 245,700 | 3,251,000 | 0.42% | ||
| 31 | BlackRock Investment Management, LLC | 235,336 | 3,113,000 | 0.41% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 223,058 | 2,951,000 | 0.38% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 210,665 | 2,787,000 | 0.36% | ||
| 34 | PAULSON & CO. INC. | 205,200 | 2,715,000 | 0.35% | ||
| 35 | Alyeska Investment Group, L.P. | 192,020 | 2,540,000 | 0.33% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,400 | 2,201,000 | 0.29% | Call | |
| 37 | D. E. Shaw & Co., Inc. | 134,322 | 1,777,000 | 0.23% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 127,548 | 1,687,000 | 0.22% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 120,500 | 1,594,000 | 0.21% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,572 | 1,529,000 | 0.20% | ||
| 41 | SECTORAL ASSET MANAGEMENT INC | 103,300 | 1,367,000 | 0.18% | ||
| 42 | AMERIPRISE FINANCIAL INC | 99,386 | 1,314,000 | 0.17% | ||
| 43 | UBS Group AG | 93,953 | 1,243,000 | 0.16% | ||
| 44 | Swiss National Bank | 92,300 | 1,221,000 | 0.16% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 86,900 | 1,150,000 | 0.15% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 86,200 | 1,140,000 | 0.15% | ||
| 47 | QS Investors, LLC | 73,262 | 969,000 | 0.13% | ||
| 48 | RHUMBLINE ADVISERS | 70,949 | 939,000 | 0.12% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 67,100 | 888,000 | 0.12% | ||
| 50 | CREDIT SUISSE AG/ | 64,310 | 851,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
