| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,449,749 | 115,248,000 | 17.44% | ||
| 2 | Palo Alto Investors LP | 4,625,648 | 71,559,000 | 10.83% | ||
| 3 | Point72 Asset Management, L.P. | 2,840,830 | 43,948,000 | 6.65% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,241,631 | 34,678,000 | 5.25% | ||
| 5 | BlackRock Fund Advisors | 1,959,185 | 30,309,000 | 4.59% | ||
| 6 | JPMORGAN CHASE & CO | 1,904,739 | 29,467,000 | 4.46% | ||
| 7 | STATE STREET CORP | 1,898,115 | 29,365,000 | 4.44% | ||
| 8 | Tourbillon Capital Partners, L.P. | 1,500,000 | 23,205,000 | 3.51% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 1,376,887 | 21,300,000 | 3.22% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,360,540 | 21,048,000 | 3.18% | ||
| 11 | VANGUARD GROUP INC | 1,327,233 | 20,533,000 | 3.11% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,158,574 | 17,923,000 | 2.71% | ||
| 13 | UBS Group AG | 1,113,337 | 17,223,000 | 2.61% | ||
| 14 | BAKER BROS. ADVISORS LP | 1,107,850 | 17,138,000 | 2.59% | ||
| 15 | Redmile Group, LLC | 1,012,371 | 15,661,000 | 2.37% | ||
| 16 | STIFEL FINANCIAL CORP | 533,146 | 12,853,000 | 1.94% | ||
| 17 | JENNISON ASSOCIATES LLC | 762,603 | 11,797,000 | 1.79% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 685,812 | 10,610,000 | 1.61% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 677,600 | 10,482,000 | 1.59% | ||
| 20 | CITADEL ADVISORS LLC | 675,264 | 10,446,000 | 1.58% | ||
| 21 | NORTHERN TRUST CORP | 562,255 | 8,698,000 | 1.32% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 430,187 | 6,655,000 | 1.01% | ||
| 23 | MORGAN STANLEY | 424,631 | 6,569,000 | 0.99% | ||
| 24 | TEACHERS ADVISORS, LLC | 290,886 | 4,500,000 | 0.68% | ||
| 25 | D. E. Shaw & Co., Inc. | 270,750 | 4,188,000 | 0.63% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 261,860 | 4,050,000 | 0.61% | ||
| 27 | Bank of New York Mellon Corp | 251,377 | 3,889,000 | 0.59% | ||
| 28 | Asset Management One Co., Ltd. | 240,490 | 3,734,000 | 0.57% | ||
| 29 | PUTNAM INVESTMENTS LLC | 241,221 | 3,732,000 | 0.56% | ||
| 30 | Candriam S.C.A. | 220,000 | 3,403,000 | 0.51% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 205,905 | 3,185,000 | 0.48% | ||
| 32 | DEUTSCHE BANK AG\ | 191,011 | 2,953,000 | 0.45% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 173,100 | 2,678,000 | 0.41% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 155,591 | 2,407,000 | 0.36% | ||
| 35 | QS Investors, LLC | 143,600 | 2,222,000 | 0.34% | ||
| 36 | BlackRock Investment Management, LLC | 142,957 | 2,212,000 | 0.33% | ||
| 37 | AMERIPRISE FINANCIAL INC | 119,917 | 1,855,000 | 0.28% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 100,800 | 1,604,000 | 0.24% | ||
| 39 | Green Owl Capital Management, LLC | 100,000 | 1,547,000 | 0.23% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 91,929 | 1,422,000 | 0.22% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 88,600 | 1,371,000 | 0.21% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,000 | 1,361,000 | 0.21% | Put | |
| 43 | Allianz Asset Management GmbH | 86,997 | 1,346,000 | 0.20% | ||
| 44 | Trexquant Investment LP | 75,987 | 1,175,000 | 0.18% | ||
| 45 | Connor, Clark & Lunn Investment Management Ltd. | 71,300 | 1,103,000 | 0.17% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,800 | 1,080,000 | 0.16% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,500 | 1,013,000 | 0.15% | Call | |
| 48 | FRANKLIN STREET ADVISORS INC /NC | 64,729 | 1,002,000 | 0.15% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 60,200 | 931,000 | 0.14% | ||
| 50 | CREDIT SUISSE AG/ | 55,952 | 865,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
