| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,617,514 | 179,245,000 | 15.96% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,371,147 | 174,120,000 | 15.51% | ||
| 3 | Palo Alto Investors LP | 4,649,448 | 96,709,000 | 8.61% | ||
| 4 | JPMORGAN CHASE & CO | 2,065,789 | 42,969,000 | 3.83% | ||
| 5 | BlackRock Fund Advisors | 2,016,513 | 41,943,000 | 3.74% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,967,128 | 40,916,000 | 3.64% | ||
| 7 | STATE STREET CORP | 1,776,482 | 36,952,000 | 3.29% | ||
| 8 | CITADEL ADVISORS LLC | 1,652,123 | 34,364,000 | 3.06% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,628,531 | 33,873,000 | 3.02% | ||
| 10 | BAKER BROS. ADVISORS LP | 1,583,490 | 32,937,000 | 2.93% | ||
| 11 | VANGUARD GROUP INC | 1,565,733 | 32,567,000 | 2.90% | ||
| 12 | Redmile Group, LLC | 1,381,828 | 28,742,000 | 2.56% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,363,418 | 28,359,000 | 2.53% | ||
| 14 | Tourbillon Capital Partners, L.P. | 1,250,000 | 26,000,000 | 2.32% | ||
| 15 | JENNISON ASSOCIATES LLC | 1,163,556 | 24,202,000 | 2.16% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 1,157,604 | 24,078,000 | 2.14% | ||
| 17 | UBS Group AG | 1,128,978 | 23,483,000 | 2.09% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 585,812 | 12,185,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 563,633 | 11,723,000 | 1.04% | ||
| 20 | SENZAR ASSET MANAGEMENT, LLC | 539,107 | 11,213,000 | 1.00% | ||
| 21 | MORGAN STANLEY | 488,302 | 10,157,000 | 0.90% | ||
| 22 | STIFEL FINANCIAL CORP | 483,593 | 10,059,000 | 0.90% | ||
| 23 | CITIGROUP INC | 482,093 | 10,027,000 | 0.89% | ||
| 24 | EMERALD ADVISERS, LLC | 416,622 | 8,762,000 | 0.78% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 367,720 | 7,733,000 | 0.69% | ||
| 26 | Rock Springs Capital Management LP | 365,000 | 7,592,000 | 0.68% | ||
| 27 | TEACHERS ADVISORS, LLC | 292,945 | 6,093,000 | 0.54% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 287,619 | 5,982,000 | 0.53% | ||
| 29 | Asset Management One Co., Ltd. | 272,862 | 5,754,000 | 0.51% | ||
| 30 | Bank of New York Mellon Corp | 265,821 | 5,529,000 | 0.49% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 250,000 | 5,200,000 | 0.46% | ||
| 32 | PUTNAM INVESTMENTS LLC | 240,200 | 4,996,000 | 0.44% | ||
| 33 | First Light Asset Management, LLC | 210,066 | 4,369,000 | 0.39% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 208,805 | 4,343,000 | 0.39% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 207,468 | 4,315,000 | 0.38% | ||
| 36 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 200,837 | 4,177,000 | 0.37% | ||
| 37 | DEUTSCHE BANK AG\ | 195,263 | 4,060,000 | 0.36% | ||
| 38 | Candriam S.C.A. | 190,000 | 3,953,000 | 0.35% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 173,100 | 3,601,000 | 0.32% | ||
| 40 | ACUTA CAPITAL PARTNERS, LLC | 150,000 | 3,120,000 | 0.28% | ||
| 41 | BlackRock Investment Management, LLC | 144,425 | 3,004,000 | 0.27% | ||
| 42 | QS Investors, LLC | 143,244 | 2,978,000 | 0.27% | ||
| 43 | AMERIPRISE FINANCIAL INC | 136,088 | 2,831,000 | 0.25% | ||
| 44 | D. E. Shaw & Co., Inc. | 128,575 | 2,674,000 | 0.24% | ||
| 45 | DENVER INVESTMENT ADVISORS LLC | 117,550 | 2,445,000 | 0.22% | ||
| 46 | Alyeska Investment Group, L.P. | 115,000 | 2,392,000 | 0.21% | ||
| 47 | Connor, Clark & Lunn Investment Management Ltd. | 105,800 | 2,201,000 | 0.20% | ||
| 48 | TD ASSET MANAGEMENT INC | 92,100 | 1,916,000 | 0.17% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 90,329 | 1,879,000 | 0.17% | ||
| 50 | GOLDMAN SACHS GROUP INC | 89,737 | 1,867,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
