| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,645,081 | 122,203,000 | 16.81% | ||
| 2 | FMR LLC | 9,278,632 | 117,561,000 | 16.18% | ||
| 3 | Palo Alto Investors LP | 4,790,800 | 60,699,000 | 8.35% | ||
| 4 | ORBIMED ADVISORS LLC | 3,469,900 | 43,964,000 | 6.05% | ||
| 5 | VANGUARD GROUP INC | 3,253,947 | 41,228,000 | 5.67% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,913,917 | 36,921,000 | 5.08% | ||
| 7 | BlackRock Fund Advisors | 2,291,187 | 29,029,000 | 3.99% | ||
| 8 | JPMORGAN CHASE & CO | 2,084,507 | 26,410,000 | 3.63% | ||
| 9 | Visium Asset Management, LP | 1,583,300 | 20,060,000 | 2.76% | ||
| 10 | STATE STREET CORP | 1,531,234 | 19,399,000 | 2.67% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,527,956 | 19,359,000 | 2.66% | ||
| 12 | BAKER BROS. ADVISORS LP | 1,500,000 | 19,005,000 | 2.61% | ||
| 13 | JENNISON ASSOCIATES LLC | 1,177,504 | 14,919,000 | 2.05% | ||
| 14 | SENZAR ASSET MANAGEMENT, LLC | 1,104,998 | 14,000,325 | 1.93% | ||
| 15 | NORTHERN TRUST CORP | 717,758 | 9,094,000 | 1.25% | ||
| 16 | MORGAN STANLEY | 691,024 | 8,755,000 | 1.20% | ||
| 17 | EMERALD MUTUAL FUND ADVISERS TRUST | 607,213 | 7,693,000 | 1.06% | ||
| 18 | EMERALD ADVISERS, LLC | 586,919 | 7,436,000 | 1.02% | ||
| 19 | Invesco Ltd. | 566,028 | 7,172,000 | 0.99% | ||
| 20 | DEUTSCHE BANK AG\ | 490,825 | 6,216,000 | 0.86% | ||
| 21 | Rock Springs Capital Management LP | 450,000 | 5,702,000 | 0.78% | ||
| 22 | NORGES BANK | 443,525 | 5,619,000 | 0.77% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 424,851 | 5,382,000 | 0.74% | ||
| 24 | UBS Group AG | 382,810 | 4,851,000 | 0.67% | ||
| 25 | TEACHERS ADVISORS, LLC | 306,146 | 3,879,000 | 0.53% | ||
| 26 | Asset Management One Co., Ltd. | 298,820 | 3,681,000 | 0.51% | ||
| 27 | Bank of New York Mellon Corp | 285,994 | 3,623,000 | 0.50% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 241,998 | 3,066,000 | 0.42% | ||
| 29 | AMERIPRISE FINANCIAL INC | 229,579 | 2,908,000 | 0.40% | ||
| 30 | TD ASSET MANAGEMENT INC | 229,100 | 2,903,000 | 0.40% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 220,464 | 2,794,000 | 0.38% | ||
| 32 | BlackRock Investment Management, LLC | 216,472 | 2,743,000 | 0.38% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 213,238 | 2,702,000 | 0.37% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 212,398 | 2,691,000 | 0.37% | ||
| 35 | EVENTIDE ASSET MANAGEMENT, LLC | 210,000 | 2,661,000 | 0.37% | ||
| 36 | PAULSON & CO. INC. | 205,200 | 2,600,000 | 0.36% | ||
| 37 | CITIGROUP INC | 189,485 | 2,401,000 | 0.33% | ||
| 38 | RENAISSANCE TECHNOLOGIES LLC | 183,787 | 2,329,000 | 0.32% | ||
| 39 | Tekla Capital Management LLC | 178,600 | 2,263,000 | 0.31% | ||
| 40 | First Light Asset Management, LLC | 177,930 | 2,254,000 | 0.31% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 160,500 | 2,034,000 | 0.28% | Call | |
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 130,313 | 1,651,000 | 0.23% | ||
| 43 | D. E. Shaw & Co., Inc. | 122,819 | 1,556,000 | 0.21% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 95,000 | 1,204,000 | 0.17% | ||
| 45 | Swiss National Bank | 93,600 | 1,144,000 | 0.16% | ||
| 46 | QS Investors, LLC | 87,407 | 1,107,000 | 0.15% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 86,900 | 1,101,000 | 0.15% | ||
| 48 | Candriam S.C.A. | 75,000 | 945,000 | 0.13% | ||
| 49 | GOLDMAN SACHS GROUP INC | 69,768 | 884,000 | 0.12% | ||
| 50 | RHUMBLINE ADVISERS | 64,816 | 821,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
