| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,037,872 | 145,750,000 | 17.38% | ||
| 2 | FMR LLC | 9,281,685 | 134,770,000 | 16.07% | ||
| 3 | ORBIMED ADVISORS LLC | 5,251,100 | 76,246,000 | 9.09% | ||
| 4 | Palo Alto Investors LP | 5,091,298 | 73,926,000 | 8.82% | ||
| 5 | VANGUARD GROUP INC | 3,484,557 | 50,596,000 | 6.03% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,877,537 | 41,782,000 | 4.98% | ||
| 7 | BlackRock Fund Advisors | 2,392,925 | 34,745,000 | 4.14% | ||
| 8 | JPMORGAN CHASE & CO | 1,598,635 | 23,213,000 | 2.77% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,547,283 | 22,467,000 | 2.68% | ||
| 10 | STATE STREET CORP | 1,414,162 | 20,535,000 | 2.45% | ||
| 11 | JENNISON ASSOCIATES LLC | 1,163,793 | 16,898,000 | 2.02% | ||
| 12 | EMERALD ADVISERS, LLC | 1,000,610 | 14,529,000 | 1.73% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 951,061 | 13,809,000 | 1.65% | ||
| 14 | NORTHERN TRUST CORP | 760,407 | 11,042,000 | 1.32% | ||
| 15 | CITADEL ADVISORS LLC | 727,475 | 10,563,000 | 1.26% | ||
| 16 | SENZAR ASSET MANAGEMENT, LLC | 593,336 | 8,615,239 | 1.03% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 524,859 | 7,621,000 | 0.91% | ||
| 18 | GOLDMAN SACHS GROUP INC | 516,292 | 7,497,000 | 0.89% | ||
| 19 | Rock Springs Capital Management LP | 503,000 | 7,304,000 | 0.87% | ||
| 20 | DEUTSCHE BANK AG\ | 488,809 | 7,096,000 | 0.85% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 454,018 | 6,592,000 | 0.79% | ||
| 22 | BAKER BROS. ADVISORS LP | 400,000 | 5,808,000 | 0.69% | ||
| 23 | MORGAN STANLEY | 387,336 | 5,624,000 | 0.67% | ||
| 24 | AXA S.A. | 367,417 | 5,335,000 | 0.64% | ||
| 25 | TEACHERS ADVISORS, LLC | 364,051 | 5,286,000 | 0.63% | ||
| 26 | NEXTHERA CAPITAL LP | 322,044 | 4,676,000 | 0.56% | ||
| 27 | STATE OF MICHIGAN RETIREMENT SYSTEM | 300,000 | 4,356,000 | 0.52% | ||
| 28 | Bank of New York Mellon Corp | 294,040 | 4,270,000 | 0.51% | ||
| 29 | Asset Management One Co., Ltd. | 265,927 | 3,707,000 | 0.44% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,166 | 3,633,000 | 0.43% | ||
| 31 | TD ASSET MANAGEMENT INC | 242,900 | 3,527,000 | 0.42% | ||
| 32 | CITIGROUP INC | 238,603 | 3,464,000 | 0.41% | ||
| 33 | BlackRock Investment Management, LLC | 235,774 | 3,423,000 | 0.41% | ||
| 34 | NORGES BANK | 240,767 | 3,339,000 | 0.40% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 229,166 | 3,327,000 | 0.40% | ||
| 36 | UBS Group AG | 226,513 | 3,289,000 | 0.39% | ||
| 37 | PRINCIPAL FINANCIAL GROUP INC | 209,328 | 3,039,000 | 0.36% | ||
| 38 | PAULSON & CO. INC. | 205,200 | 2,980,000 | 0.36% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 197,700 | 2,871,000 | 0.34% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,700 | 2,188,000 | 0.26% | Call | |
| 41 | D. E. Shaw & Co., Inc. | 134,382 | 1,951,000 | 0.23% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 131,048 | 1,903,000 | 0.23% | ||
| 43 | CREDIT SUISSE AG/ | 120,282 | 1,747,000 | 0.21% | ||
| 44 | AMERIPRISE FINANCIAL INC | 97,568 | 1,418,000 | 0.17% | ||
| 45 | Swiss National Bank | 92,300 | 1,340,000 | 0.16% | ||
| 46 | QS Investors, LLC | 87,407 | 1,269,000 | 0.15% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 86,900 | 1,262,000 | 0.15% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 86,200 | 1,252,000 | 0.15% | ||
| 49 | ALPS ADVISORS INC | 78,884 | 1,145,000 | 0.14% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,200 | 1,063,000 | 0.13% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
