| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 9,264,039 | 172,033,000 | 16.21% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,041,389 | 167,899,000 | 15.82% | ||
| 3 | Palo Alto Investors LP | 4,768,800 | 88,557,000 | 8.35% | ||
| 4 | ORBIMED ADVISORS LLC | 3,145,301 | 58,408,000 | 5.50% | ||
| 5 | VANGUARD GROUP INC | 2,950,707 | 54,794,000 | 5.16% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,587,395 | 48,048,000 | 4.53% | ||
| 7 | BlackRock Fund Advisors | 2,344,745 | 43,542,000 | 4.10% | ||
| 8 | JPMORGAN CHASE & CO | 2,097,972 | 38,959,000 | 3.67% | ||
| 9 | STATE STREET CORP | 1,957,007 | 36,340,000 | 3.42% | ||
| 10 | BAKER BROS. ADVISORS LP | 1,583,490 | 29,405,000 | 2.77% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,471,340 | 27,323,000 | 2.57% | ||
| 12 | CITADEL ADVISORS LLC | 1,235,860 | 22,950,000 | 2.16% | ||
| 13 | JENNISON ASSOCIATES LLC | 1,164,601 | 21,627,000 | 2.04% | ||
| 14 | Redmile Group, LLC | 947,966 | 17,604,000 | 1.66% | ||
| 15 | MORGAN STANLEY | 868,821 | 16,133,000 | 1.52% | ||
| 16 | UBS Group AG | 865,680 | 16,076,000 | 1.52% | ||
| 17 | NORTHERN TRUST CORP | 688,389 | 12,783,000 | 1.20% | ||
| 18 | SENZAR ASSET MANAGEMENT, LLC | 575,407 | 10,685,308 | 1.01% | ||
| 19 | Tourbillon Capital Partners, L.P. | 575,062 | 10,679,000 | 1.01% | ||
| 20 | EMERALD ADVISERS, LLC | 483,657 | 8,982,000 | 0.85% | ||
| 21 | EMERALD MUTUAL FUND ADVISERS TRUST | 468,720 | 8,704,000 | 0.82% | ||
| 22 | DEUTSCHE BANK AG\ | 459,348 | 8,527,000 | 0.80% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 404,416 | 7,510,000 | 0.71% | ||
| 24 | CITIGROUP INC | 392,497 | 7,288,000 | 0.69% | ||
| 25 | Rock Springs Capital Management LP | 365,000 | 6,778,000 | 0.64% | ||
| 26 | D. E. Shaw & Co., Inc. | 308,012 | 5,720,000 | 0.54% | ||
| 27 | TEACHERS ADVISORS, LLC | 302,488 | 5,617,000 | 0.53% | ||
| 28 | Bank of New York Mellon Corp | 273,080 | 5,072,000 | 0.48% | ||
| 29 | First Light Asset Management, LLC | 272,393 | 5,058,000 | 0.48% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 247,063 | 4,588,000 | 0.43% | ||
| 31 | PUTNAM INVESTMENTS LLC | 240,800 | 4,472,000 | 0.42% | ||
| 32 | TD ASSET MANAGEMENT INC | 234,500 | 4,355,000 | 0.41% | ||
| 33 | Asset Management One Co., Ltd. | 241,445 | 4,205,000 | 0.40% | ||
| 34 | AMERIPRISE FINANCIAL INC | 205,709 | 3,819,000 | 0.36% | ||
| 35 | BlackRock Investment Management, LLC | 205,575 | 3,818,000 | 0.36% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 202,705 | 3,764,000 | 0.35% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,888 | 3,378,000 | 0.32% | ||
| 38 | SPHERA FUNDS MANAGEMENT LTD. | 165,000 | 3,064,000 | 0.29% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,200 | 2,845,000 | 0.27% | Call | |
| 40 | Candriam S.C.A. | 148,800 | 2,763,000 | 0.26% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 144,600 | 2,685,000 | 0.25% | ||
| 42 | QS Investors, LLC | 141,644 | 2,630,000 | 0.25% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 124,000 | 2,303,000 | 0.22% | ||
| 44 | NORGES BANK | 118,662 | 2,204,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112,125 | 2,082,000 | 0.20% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 107,048 | 1,988,000 | 0.19% | ||
| 47 | SEI INVESTMENTS CO | 98,974 | 1,838,000 | 0.17% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 90,600 | 1,682,000 | 0.16% | ||
| 49 | GROUP ONE TRADING LLC | 85,713 | 1,592,000 | 0.15% | ||
| 50 | Swiss National Bank | 75,800 | 1,408,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
