| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,010,522 | 98,704,000 | 17.58% | ||
| 2 | FMR LLC | 8,432,774 | 83,147,000 | 14.81% | ||
| 3 | Palo Alto Investors LP | 5,054,713 | 49,839,000 | 8.87% | ||
| 4 | ORBIMED ADVISORS LLC | 4,158,600 | 41,004,000 | 7.30% | ||
| 5 | VANGUARD GROUP INC | 3,411,733 | 33,640,000 | 5.99% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 2,853,938 | 28,139,000 | 5.01% | ||
| 7 | BlackRock Fund Advisors | 2,268,606 | 22,368,000 | 3.98% | ||
| 8 | JPMORGAN CHASE & CO | 1,974,261 | 19,467,000 | 3.47% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,521,798 | 15,005,000 | 2.67% | ||
| 10 | BAKER BROS. ADVISORS LP | 1,500,000 | 14,790,000 | 2.63% | ||
| 11 | STATE STREET CORP | 1,359,861 | 13,409,000 | 2.39% | ||
| 12 | JENNISON ASSOCIATES LLC | 1,195,455 | 11,787,000 | 2.10% | ||
| 13 | SENZAR ASSET MANAGEMENT, LLC | 788,936 | 7,778,909 | 1.39% | ||
| 14 | NORTHERN TRUST CORP | 751,149 | 7,407,000 | 1.32% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 667,848 | 6,585,000 | 1.17% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 660,690 | 6,514,000 | 1.16% | ||
| 17 | EMERALD ADVISERS, LLC | 630,159 | 6,213,000 | 1.11% | ||
| 18 | DEUTSCHE BANK AG\ | 529,650 | 5,219,000 | 0.93% | ||
| 19 | Rock Springs Capital Management LP | 497,500 | 4,905,000 | 0.87% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 450,499 | 4,441,000 | 0.79% | ||
| 21 | CITADEL ADVISORS LLC | 422,800 | 4,169,000 | 0.74% | ||
| 22 | NORGES BANK | 418,525 | 4,127,000 | 0.73% | ||
| 23 | MORGAN STANLEY | 408,781 | 4,031,000 | 0.72% | ||
| 24 | AXA S.A. | 325,133 | 3,206,000 | 0.57% | ||
| 25 | TEACHERS ADVISORS, LLC | 310,285 | 3,059,000 | 0.54% | ||
| 26 | AMERIPRISE FINANCIAL INC | 303,803 | 2,998,000 | 0.53% | ||
| 27 | Bank of New York Mellon Corp | 287,391 | 2,834,000 | 0.50% | ||
| 28 | Asset Management One Co., Ltd. | 281,674 | 2,782,000 | 0.50% | ||
| 29 | TD ASSET MANAGEMENT INC | 238,400 | 2,351,000 | 0.42% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 237,824 | 2,345,000 | 0.42% | ||
| 31 | UBS Group AG | 237,759 | 2,344,000 | 0.42% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 235,855 | 2,326,000 | 0.41% | ||
| 33 | BlackRock Investment Management, LLC | 231,062 | 2,278,000 | 0.41% | ||
| 34 | ACUTA CAPITAL PARTNERS, LLC | 220,000 | 2,169,000 | 0.39% | ||
| 35 | PRINCIPAL FINANCIAL GROUP INC | 207,373 | 2,045,000 | 0.36% | ||
| 36 | CITIGROUP INC | 207,280 | 2,044,000 | 0.36% | ||
| 37 | PAULSON & CO. INC. | 205,200 | 2,023,000 | 0.36% | ||
| 38 | Point72 Asset Management, L.P. | 201,354 | 1,985,000 | 0.35% | ||
| 39 | ORBIMED ADVISORS LLC | 200,000 | 1,972,000 | 0.35% | Call | |
| 40 | GOLDMAN SACHS GROUP INC | 195,525 | 1,928,000 | 0.34% | ||
| 41 | D. E. Shaw & Co., Inc. | 195,258 | 1,925,000 | 0.34% | ||
| 42 | NEXTHERA CAPITAL LP | 168,700 | 1,663,000 | 0.30% | ||
| 43 | RENAISSANCE TECHNOLOGIES LLC | 149,300 | 1,472,000 | 0.26% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 148,400 | 1,463,000 | 0.26% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,848 | 1,280,000 | 0.23% | ||
| 46 | CREDIT SUISSE AG/ | 98,698 | 973,000 | 0.17% | ||
| 47 | Swiss National Bank | 95,800 | 945,000 | 0.17% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 92,100 | 908,000 | 0.16% | ||
| 49 | QS Investors, LLC | 87,407 | 862,000 | 0.15% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 86,900 | 857,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
