| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,889,436 | 112,135,000 | 17.31% | ||
| 2 | WELLS FARGO & COMPANY/MN | 2,130,011 | 40,555,000 | 6.26% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,016,147 | 38,387,000 | 5.93% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 1,644,674 | 31,315,000 | 4.84% | ||
| 5 | STATE STREET CORP | 1,461,978 | 27,830,000 | 4.30% | ||
| 6 | FRANKLIN RESOURCES INC | 1,452,200 | 27,650,000 | 4.27% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,401,192 | 26,679,000 | 4.12% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 1,172,121 | 22,317,000 | 3.45% | ||
| 9 | BlackRock Fund Advisors | 970,670 | 18,482,000 | 2.85% | ||
| 10 | VANGUARD GROUP INC | 939,654 | 17,892,000 | 2.76% | ||
| 11 | JPMORGAN CHASE & CO | 935,801 | 17,818,000 | 2.75% | ||
| 12 | AMERIPRISE FINANCIAL INC | 934,020 | 17,781,000 | 2.75% | ||
| 13 | GOLDMAN SACHS GROUP INC | 781,600 | 14,882,000 | 2.30% | Call | |
| 14 | Tourbillon Capital Partners, L.P. | 700,000 | 13,328,000 | 2.06% | ||
| 15 | BARCLAYS PLC | 605,000 | 11,495,000 | 1.77% | Call | |
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 590,200 | 11,238,000 | 1.74% | Put | |
| 17 | GOLDMAN SACHS GROUP INC | 584,400 | 11,127,000 | 1.72% | Put | |
| 18 | BAKER BROS. ADVISORS LP | 554,050 | 10,549,000 | 1.63% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 485,600 | 9,246,000 | 1.43% | Call | |
| 20 | NORTHERN TRUST CORP | 473,294 | 9,012,000 | 1.39% | ||
| 21 | MARSHALL WACE, LLP | 415,299 | 7,907,000 | 1.22% | ||
| 22 | Invesco Ltd. | 380,280 | 7,241,000 | 1.12% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 340,000 | 6,474,000 | 1.00% | ||
| 24 | Palo Alto Investors LP | 316,699 | 6,030,000 | 0.93% | ||
| 25 | OXFORD ASSET MANAGEMENT LLP | 312,397 | 5,948,000 | 0.92% | ||
| 26 | Informed Momentum Co LLC | 304,022 | 5,789,000 | 0.89% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 283,300 | 5,394,000 | 0.83% | Call | |
| 28 | WEXFORD CAPITAL LP | 258,025 | 4,913,000 | 0.76% | ||
| 29 | Bank of New York Mellon Corp | 252,665 | 4,811,000 | 0.74% | ||
| 30 | PUTNAM INVESTMENTS LLC | 241,859 | 4,605,000 | 0.71% | ||
| 31 | BARCLAYS PLC | 235,400 | 4,473,000 | 0.69% | Put | |
| 32 | Nationwide Fund Advisors | 207,248 | 3,946,000 | 0.61% | ||
| 33 | SAC Capital Advisors LP | 203,000 | 3,865,000 | 0.60% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 190,034 | 3,618,000 | 0.56% | ||
| 35 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 184,300 | 3,510,000 | 0.54% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,440 | 3,436,000 | 0.53% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 171,223 | 3,260,000 | 0.50% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 170,567 | 3,248,000 | 0.50% | ||
| 39 | GOLDMAN SACHS GROUP INC | 166,179 | 3,164,000 | 0.49% | ||
| 40 | Deer VII & Co. Ltd. | 170,962 | 2,930,000 | 0.45% | ||
| 41 | Manatuck Hill Partners, LLC | 146,761 | 2,794,000 | 0.43% | ||
| 42 | DEUTSCHE BANK AG\ | 135,255 | 2,573,000 | 0.40% | ||
| 43 | Ghost Tree Capital, LLC | 135,000 | 2,570,000 | 0.40% | ||
| 44 | Nicholas Investment Partners, LP | 129,567 | 2,466,000 | 0.38% | ||
| 45 | LORD, ABBETT & CO. LLC | 121,972 | 2,322,000 | 0.36% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 120,000 | 2,285,000 | 0.35% | Put | |
| 47 | BARCLAYS PLC | 106,502 | 2,024,000 | 0.31% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 122,857 | 2,016,000 | 0.31% | ||
| 49 | RUSSELL FRANK CO/ | 119,254 | 1,892,000 | 0.29% | ||
| 50 | BlackRock Investment Management, LLC | 95,887 | 1,826,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
