| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 4,242,943 | 197,505,000 | 28.07% | ||
| 2 | FMR LLC | 3,414,131 | 158,928,000 | 22.58% | ||
| 3 | Foresite Capital Management I, LLC | 1,377,410 | 64,118,000 | 9.11% | ||
| 4 | BLACKROCK ADVISORS LLC | 736,935 | 34,304,000 | 4.87% | ||
| 5 | PFM Health Sciences, LP | 662,842 | 30,855,000 | 4.38% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 412,479 | 19,201,000 | 2.73% | ||
| 7 | Cormorant Asset Management, LP | 385,000 | 17,922,000 | 2.55% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 338,172 | 15,742,000 | 2.24% | ||
| 9 | BlackRock Fund Advisors | 306,097 | 14,249,000 | 2.02% | ||
| 10 | VANGUARD GROUP INC | 296,407 | 13,798,000 | 1.96% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 268,540 | 12,501,000 | 1.78% | ||
| 12 | BlackRock Group LTD | 231,517 | 10,777,000 | 1.53% | ||
| 13 | STATE STREET CORP | 168,975 | 7,865,000 | 1.12% | ||
| 14 | PointState Capital LP | 150,000 | 6,983,000 | 0.99% | ||
| 15 | Visium Asset Management, LP | 150,000 | 6,983,000 | 0.99% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 133,469 | 6,213,000 | 0.88% | ||
| 17 | LORD, ABBETT & CO. LLC | 122,126 | 5,685,000 | 0.81% | ||
| 18 | TCW GROUP INC | 122,045 | 5,681,000 | 0.81% | ||
| 19 | BlackRock Finance, Inc. | 108,312 | 5,042,000 | 0.72% | ||
| 20 | BAKER BROS. ADVISORS LP | 94,095 | 4,380,000 | 0.62% | ||
| 21 | GUGGENHEIM CAPITAL LLC | 90,077 | 4,193,000 | 0.60% | ||
| 22 | NORTHERN TRUST CORP | 89,456 | 4,164,000 | 0.59% | ||
| 23 | EverPoint Asset Management, LLC | 80,000 | 3,724,000 | 0.53% | ||
| 24 | CITADEL ADVISORS LLC | 78,900 | 3,673,000 | 0.52% | ||
| 25 | DRIEHAUS CAPITAL MANAGEMENT LLC | 76,820 | 3,576,000 | 0.51% | ||
| 26 | GREAT POINT PARTNERS LLC | 75,000 | 3,491,000 | 0.50% | ||
| 27 | TEACHERS ADVISORS, LLC | 64,524 | 3,004,000 | 0.43% | ||
| 28 | BlackRock Investment Management, LLC | 62,936 | 2,930,000 | 0.42% | ||
| 29 | JPMORGAN CHASE & CO | 53,325 | 2,483,000 | 0.35% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 48,220 | 2,244,000 | 0.32% | ||
| 31 | Bank of New York Mellon Corp | 47,473 | 2,210,000 | 0.31% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 47,431 | 2,208,000 | 0.31% | ||
| 33 | PERCEPTIVE ADVISORS LLC | 45,643 | 2,125,000 | 0.30% | ||
| 34 | MORGAN STANLEY | 45,231 | 2,106,000 | 0.30% | ||
| 35 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 39,980 | 1,861,000 | 0.26% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 31,900 | 1,485,000 | 0.21% | ||
| 37 | Spark Investment Management LLC | 31,800 | 1,479,000 | 0.21% | ||
| 38 | Opaleye Management Inc. | 30,000 | 1,397,000 | 0.20% | ||
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 30,000 | 1,397,000 | 0.20% | ||
| 40 | Absolute Return Capital, LLC | 27,268 | 1,269,000 | 0.18% | ||
| 41 | Partner Investment Management, L.P. | 24,922 | 1,160,000 | 0.16% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,973 | 1,116,000 | 0.16% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,600 | 1,052,000 | 0.15% | ||
| 44 | Laurion Capital Management LP | 18,200 | 847,000 | 0.12% | ||
| 45 | ROYAL BANK OF CANADA | 17,700 | 824,000 | 0.12% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 15,924 | 741,000 | 0.11% | ||
| 47 | TUDOR INVESTMENT CORP ET AL | 15,000 | 698,000 | 0.10% | ||
| 48 | JANE STREET GROUP, LLC | 14,132 | 658,000 | 0.09% | ||
| 49 | Swiss National Bank | 12,300 | 573,000 | 0.08% | ||
| 50 | Nuveen Asset Management, LLC | 10,870 | 506,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
