| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,905,084 | 183,597,000 | 26.08% | ||
| 2 | FRANKLIN RESOURCES INC | 4,652,759 | 174,154,000 | 24.74% | ||
| 3 | Foresite Capital Management I, LLC | 999,275 | 37,403,000 | 5.31% | ||
| 4 | PFM Health Sciences, LP | 850,337 | 31,828,000 | 4.52% | ||
| 5 | BlackRock Fund Advisors | 765,388 | 28,648,000 | 4.07% | ||
| 6 | STATE STREET CORP | 673,646 | 25,215,000 | 3.58% | ||
| 7 | BLACKROCK ADVISORS LLC | 607,285 | 22,731,000 | 3.23% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 529,920 | 19,835,000 | 2.82% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 418,680 | 15,671,000 | 2.23% | ||
| 10 | VANGUARD GROUP INC | 415,689 | 15,559,000 | 2.21% | ||
| 11 | Cormorant Asset Management, LP | 385,000 | 14,411,000 | 2.05% | ||
| 12 | Candriam S.C.A. | 298,000 | 11,154,000 | 1.58% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 219,078 | 8,200,000 | 1.16% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 216,244 | 8,093,000 | 1.15% | ||
| 15 | BlackRock Group LTD | 209,917 | 7,857,000 | 1.12% | ||
| 16 | GUGGENHEIM CAPITAL LLC | 189,258 | 7,083,000 | 1.01% | ||
| 17 | UBS Group AG | 185,740 | 6,952,000 | 0.99% | ||
| 18 | TCW GROUP INC | 168,040 | 6,289,000 | 0.89% | ||
| 19 | NORTHERN TRUST CORP | 148,574 | 5,562,000 | 0.79% | ||
| 20 | Tekla Capital Management LLC | 137,766 | 5,157,000 | 0.73% | ||
| 21 | New Leaf Venture Partners, L.L.C. | 126,687 | 4,742,000 | 0.67% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 112,300 | 4,203,000 | 0.60% | ||
| 23 | DEUTSCHE BANK AG\ | 107,540 | 4,023,000 | 0.57% | ||
| 24 | PointState Capital LP | 100,000 | 3,743,000 | 0.53% | ||
| 25 | BAKER BROS. ADVISORS LP | 94,095 | 3,522,000 | 0.50% | ||
| 26 | BlackRock Finance, Inc. | 83,355 | 3,121,000 | 0.44% | ||
| 27 | DRIEHAUS CAPITAL MANAGEMENT LLC | 81,047 | 3,034,000 | 0.43% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 77,314 | 2,893,000 | 0.41% | ||
| 29 | TEACHERS ADVISORS, LLC | 70,134 | 2,625,000 | 0.37% | ||
| 30 | BlackRock Investment Management, LLC | 69,374 | 2,597,000 | 0.37% | ||
| 31 | LORD, ABBETT & CO. LLC | 69,309 | 2,594,000 | 0.37% | ||
| 32 | Bank of New York Mellon Corp | 63,025 | 2,359,000 | 0.34% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 50,000 | 1,872,000 | 0.27% | ||
| 34 | JPMORGAN CHASE & CO | 49,800 | 1,864,000 | 0.26% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,089 | 1,800,000 | 0.26% | ||
| 36 | MORGAN STANLEY | 47,811 | 1,789,000 | 0.25% | ||
| 37 | PICTET ASSET MANAGEMENT LTD | 45,900 | 1,718,000 | 0.24% | ||
| 38 | GOLDMAN SACHS GROUP INC | 43,704 | 1,636,000 | 0.23% | ||
| 39 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 40,624 | 1,521,000 | 0.22% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 38,765 | 1,451,000 | 0.21% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,700 | 1,449,000 | 0.21% | Put | |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,980 | 1,160,000 | 0.16% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 30,000 | 1,123,000 | 0.16% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,200 | 1,093,000 | 0.16% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,137 | 941,000 | 0.13% | ||
| 46 | ProShare Advisors LLC | 24,569 | 920,000 | 0.13% | ||
| 47 | Swiss National Bank | 19,600 | 734,000 | 0.10% | ||
| 48 | CREDIT SUISSE AG/ | 18,309 | 685,000 | 0.10% | ||
| 49 | WOODSTOCK CORP | 17,512 | 655,000 | 0.09% | ||
| 50 | Partner Investment Management, L.P. | 16,399 | 614,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
