| 1 |
FRANKLIN RESOURCES INC |
5,614,726 |
59,124,000 |
22.30% |
|
|
| 2 |
FMR LLC |
5,356,672 |
56,406,000 |
21.28% |
|
|
| 3 |
Palo Alto Investors LP |
3,085,745 |
32,493,000 |
12.26% |
|
|
| 4 |
BlackRock Fund Advisors |
1,115,412 |
11,745,000 |
4.43% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
1,025,731 |
10,801,000 |
4.07% |
|
|
| 6 |
Tekla Capital Management LLC |
918,866 |
9,676,000 |
3.65% |
|
|
| 7 |
SECTORAL ASSET MANAGEMENT INC |
712,968 |
7,508,000 |
2.83% |
|
|
| 8 |
VANGUARD GROUP INC |
698,261 |
7,353,000 |
2.77% |
|
|
| 9 |
CITADEL ADVISORS LLC |
578,452 |
6,091,000 |
2.30% |
|
|
| 10 |
ALPS ADVISORS INC |
55,870 |
5,883,000 |
2.22% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
509,882 |
5,369,000 |
2.03% |
|
|
| 12 |
GOLDMAN SACHS GROUP INC |
376,600 |
3,966,000 |
1.50% |
Call |
|
| 13 |
Tekla Capital Management LLC |
316,900 |
3,337,000 |
1.26% |
Call |
|
| 14 |
STATE STREET CORP |
306,029 |
3,222,000 |
1.22% |
|
|
| 15 |
Cormorant Asset Management, LP |
300,987 |
3,169,000 |
1.20% |
|
|
| 16 |
NORTHERN TRUST CORP |
241,254 |
2,541,000 |
0.96% |
|
|
| 17 |
BAKER BROS. ADVISORS LP |
216,990 |
2,285,000 |
0.86% |
|
|
| 18 |
WELLINGTON MANAGEMENT GROUP LLP |
170,018 |
1,791,000 |
0.68% |
|
|
| 19 |
Candriam S.C.A. |
161,100 |
1,696,000 |
0.64% |
|
|
| 20 |
First Light Asset Management, LLC |
154,710 |
1,629,000 |
0.61% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
136,269 |
1,434,000 |
0.54% |
|
|
| 22 |
A.R.T. Advisors, LLC |
136,109 |
1,433,000 |
0.54% |
|
|
| 23 |
MORGAN STANLEY |
133,433 |
1,405,000 |
0.53% |
|
|
| 24 |
GUGGENHEIM CAPITAL LLC |
132,621 |
1,397,000 |
0.53% |
|
|
| 25 |
ASCEND CAPITAL, LLC |
124,780 |
1,314,000 |
0.50% |
|
|
| 26 |
STONERIDGE INVESTMENT PARTNERS LLC |
104,687 |
1,102,000 |
0.42% |
|
|
| 27 |
Bank of New York Mellon Corp |
104,506 |
1,100,000 |
0.41% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
93,200 |
981,000 |
0.37% |
Put |
|
| 29 |
DEUTSCHE BANK AG\ |
86,873 |
914,000 |
0.34% |
|
|
| 30 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
85,700 |
902,000 |
0.34% |
Call |
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
81,226 |
855,000 |
0.32% |
|
|
| 32 |
JPMORGAN CHASE & CO |
80,438 |
846,000 |
0.32% |
|
|
| 33 |
BlackRock Investment Management, LLC |
79,646 |
839,000 |
0.32% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
76,786 |
809,000 |
0.31% |
|
|
| 35 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
76,208 |
802,000 |
0.30% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
67,699 |
713,000 |
0.27% |
|
|
| 37 |
PICTET ASSET MANAGEMENT LTD |
64,600 |
680,000 |
0.26% |
|
|
| 38 |
GOLDMAN SACHS GROUP INC |
59,700 |
629,000 |
0.24% |
Put |
|
| 39 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
57,180 |
603,000 |
0.23% |
|
|
| 40 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
54,937 |
578,000 |
0.22% |
|
|
| 41 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
52,400 |
551,000 |
0.21% |
Put |
|
| 42 |
D. E. Shaw & Co., Inc. |
48,700 |
513,000 |
0.19% |
|
|
| 43 |
TCW GROUP INC |
42,481 |
447,000 |
0.17% |
|
|
| 44 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
42,080 |
443,000 |
0.17% |
|
|
| 45 |
New Leaf Venture Partners, L.L.C. |
40,977 |
431,000 |
0.16% |
|
|
| 46 |
Connor, Clark & Lunn Investment Management Ltd. |
40,075 |
422,000 |
0.16% |
|
|
| 47 |
ALLIANCEBERNSTEIN L.P. |
37,027 |
390,000 |
0.15% |
|
|
| 48 |
TEACHERS ADVISORS, LLC |
33,726 |
355,000 |
0.13% |
|
|
| 49 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
33,626 |
354,000 |
0.13% |
|
|
| 50 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
30,000 |
316,000 |
0.12% |
|
|
