| 1 |
FMR LLC |
2,346,000 |
72,468,000 |
23.28% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,008,114 |
62,031,000 |
19.93% |
|
|
| 3 |
Foresite Capital Management I, LLC |
1,585,743 |
48,984,000 |
15.73% |
|
|
| 4 |
BLACKROCK ADVISORS LLC |
637,629 |
19,696,000 |
6.33% |
|
|
| 5 |
ALLIANCEBERNSTEIN L.P. |
446,415 |
13,790,000 |
4.43% |
|
|
| 6 |
WELLINGTON MANAGEMENT GROUP LLP |
382,787 |
11,824,000 |
3.80% |
|
|
| 7 |
PFM Health Sciences, LP |
309,592 |
9,563,000 |
3.07% |
|
|
| 8 |
Cormorant Asset Management, LP |
280,000 |
8,649,000 |
2.78% |
|
|
| 9 |
BlackRock Fund Advisors |
221,048 |
6,828,000 |
2.19% |
|
|
| 10 |
VANGUARD GROUP INC |
143,596 |
4,435,000 |
1.42% |
|
|
| 11 |
BlackRock Group LTD |
136,017 |
4,202,000 |
1.35% |
|
|
| 12 |
TCW GROUP INC |
125,499 |
3,876,000 |
1.25% |
|
|
| 13 |
STATE STREET CORP |
108,716 |
3,357,000 |
1.08% |
|
|
| 14 |
NORTHERN TRUST CORP |
95,970 |
2,964,000 |
0.95% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
80,963 |
2,501,000 |
0.80% |
|
|
| 16 |
BlackRock Finance, Inc. |
79,346 |
2,451,000 |
0.79% |
|
|
| 17 |
GUGGENHEIM CAPITAL LLC |
73,329 |
2,265,000 |
0.73% |
|
|
| 18 |
JPMORGAN CHASE & CO |
71,450 |
2,207,000 |
0.71% |
|
|
| 19 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
68,427 |
2,114,000 |
0.68% |
|
|
| 20 |
EVENTIDE ASSET MANAGEMENT, LLC |
67,800 |
2,094,000 |
0.67% |
|
|
| 21 |
PRINCIPAL FINANCIAL GROUP INC |
64,000 |
1,977,000 |
0.64% |
|
|
| 22 |
Informed Momentum Co LLC |
63,794 |
1,971,000 |
0.63% |
|
|
| 23 |
BAKER BROS. ADVISORS LP |
59,095 |
1,825,000 |
0.59% |
|
|
| 24 |
Bank of New York Mellon Corp |
54,809 |
1,693,000 |
0.54% |
|
|
| 25 |
PointState Capital LP |
50,000 |
1,545,000 |
0.50% |
|
|
| 26 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
46,600 |
1,439,000 |
0.46% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
44,621 |
1,378,000 |
0.44% |
|
|
| 28 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
42,400 |
1,310,000 |
0.42% |
|
|
| 29 |
Absolute Return Capital, LLC |
37,202 |
1,149,000 |
0.37% |
|
|
| 30 |
RUSSELL FRANK CO/ |
41,186 |
1,050,000 |
0.34% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
29,759 |
919,000 |
0.30% |
|
|
| 32 |
AMERIPRISE FINANCIAL INC |
27,369 |
845,000 |
0.27% |
|
|
| 33 |
BANK OF AMERICA CORP /DE/ |
23,933 |
739,000 |
0.24% |
|
|
| 34 |
BlackRock Investment Management, LLC |
22,504 |
695,000 |
0.22% |
|
|
| 35 |
GOLDMAN SACHS GROUP INC |
21,455 |
663,000 |
0.21% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,185 |
531,000 |
0.17% |
|
|
| 37 |
Spark Investment Management LLC |
17,000 |
524,000 |
0.17% |
|
|
| 38 |
A.R.T. Advisors, LLC |
15,270 |
471,000 |
0.15% |
|
|
| 39 |
MORGAN STANLEY |
15,180 |
469,000 |
0.15% |
|
|
| 40 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,200 |
439,000 |
0.14% |
|
|
| 41 |
Forward Management, LLC |
21,580 |
396,000 |
0.13% |
|
|
| 42 |
CREDIT SUISSE AG/ |
12,291 |
380,000 |
0.12% |
|
|
| 43 |
Partner Investment Management, L.P. |
12,152 |
375,000 |
0.12% |
|
|
| 44 |
TEACHERS ADVISORS, LLC |
11,216 |
346,000 |
0.11% |
|
|
| 45 |
Nuveen Asset Management, LLC |
10,430 |
322,000 |
0.10% |
|
|
| 46 |
Nationwide Fund Advisors |
10,095 |
312,000 |
0.10% |
|
|
| 47 |
ANALYTIC INVESTORS, LLC |
8,830 |
273,000 |
0.09% |
|
|
| 48 |
ProShare Advisors LLC |
7,913 |
244,000 |
0.08% |
|
|
| 49 |
METROPOLITAN LIFE INSURANCE CO/NY |
6,346 |
196,000 |
0.06% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
5,615 |
174,000 |
0.06% |
|
|
