| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,354,220 | 145,688,000 | 23.62% | ||
| 2 | FRANKLIN RESOURCES INC | 4,708,087 | 128,107,000 | 20.77% | ||
| 3 | Palo Alto Investors LP | 1,731,530 | 47,115,000 | 7.64% | ||
| 4 | STATE STREET CORP | 1,234,235 | 33,582,000 | 5.45% | ||
| 5 | BlackRock Fund Advisors | 1,064,628 | 28,969,000 | 4.70% | ||
| 6 | PFM Health Sciences, LP | 821,594 | 22,356,000 | 3.62% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 712,968 | 19,400,000 | 3.15% | ||
| 8 | VANGUARD GROUP INC | 700,716 | 19,067,000 | 3.09% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 583,570 | 15,879,000 | 2.57% | ||
| 10 | Tekla Capital Management LLC | 476,966 | 12,978,000 | 2.10% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 463,627 | 12,615,000 | 2.05% | ||
| 12 | CITADEL ADVISORS LLC | 453,249 | 12,333,000 | 2.00% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 364,452 | 9,917,000 | 1.61% | ||
| 14 | Cormorant Asset Management, LP | 300,987 | 8,190,000 | 1.33% | ||
| 15 | BLACKROCK ADVISORS LLC | 283,390 | 7,711,000 | 1.25% | ||
| 16 | BAKER BROS. ADVISORS LP | 216,990 | 5,904,000 | 0.96% | ||
| 17 | NORTHERN TRUST CORP | 173,922 | 4,732,000 | 0.77% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 159,406 | 4,337,000 | 0.70% | ||
| 19 | ASCEND CAPITAL, LLC | 149,760 | 4,075,000 | 0.66% | ||
| 20 | GUGGENHEIM CAPITAL LLC | 138,706 | 3,775,000 | 0.61% | ||
| 21 | Candriam S.C.A. | 133,000 | 3,619,000 | 0.59% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 132,030 | 3,592,000 | 0.58% | ||
| 23 | New Leaf Venture Partners, L.L.C. | 126,687 | 3,447,000 | 0.56% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 125,360 | 3,411,000 | 0.55% | ||
| 25 | Bank of New York Mellon Corp | 113,305 | 3,083,000 | 0.50% | ||
| 26 | BlackRock Investment Management, LLC | 99,060 | 2,695,000 | 0.44% | ||
| 27 | Allianz Asset Management GmbH | 98,640 | 2,684,000 | 0.44% | ||
| 28 | STONERIDGE INVESTMENT PARTNERS LLC | 90,108 | 2,452,000 | 0.40% | ||
| 29 | TEACHERS ADVISORS, LLC | 86,336 | 2,349,000 | 0.38% | ||
| 30 | JPMORGAN CHASE & CO | 84,076 | 2,287,000 | 0.37% | ||
| 31 | DEUTSCHE BANK AG\ | 81,639 | 2,220,000 | 0.36% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,871 | 2,092,000 | 0.34% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 72,191 | 1,964,000 | 0.32% | ||
| 34 | GOLDMAN SACHS GROUP INC | 65,882 | 1,793,000 | 0.29% | ||
| 35 | CREDIT SUISSE AG/ | 62,535 | 1,701,000 | 0.28% | ||
| 36 | TCW GROUP INC | 62,487 | 1,700,000 | 0.28% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 60,868 | 1,657,000 | 0.27% | ||
| 38 | GOLDMAN SACHS GROUP INC | 60,000 | 1,633,000 | 0.26% | Put | |
| 39 | GOLDMAN SACHS GROUP INC | 60,000 | 1,633,000 | 0.26% | Call | |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,700 | 1,488,000 | 0.24% | Put | |
| 41 | EDMOND DE ROTHSCHILD HOLDING S.A. | 50,000 | 1,361,000 | 0.22% | ||
| 42 | PICTET ASSET MANAGEMENT LTD | 64,600 | 1,326,000 | 0.22% | ||
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 45,700 | 1,243,000 | 0.20% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,180 | 1,148,000 | 0.19% | ||
| 45 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 39,487 | 1,074,000 | 0.17% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,400 | 990,000 | 0.16% | Call | |
| 47 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 36,000 | 980,000 | 0.16% | ||
| 48 | ALPS ADVISORS INC | 35,431 | 964,000 | 0.16% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,753 | 946,000 | 0.15% | ||
| 50 | ProShare Advisors LLC | 31,434 | 855,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
