| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,359,831 | 71,018,000 | 24.60% | ||
| 2 | FRANKLIN RESOURCES INC | 5,168,970 | 68,490,000 | 23.72% | ||
| 3 | Palo Alto Investors LP | 3,112,645 | 41,243,000 | 14.28% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 1,294,345 | 17,150,000 | 5.94% | ||
| 5 | BlackRock Fund Advisors | 1,039,544 | 13,774,000 | 4.77% | ||
| 6 | VANGUARD GROUP INC | 702,058 | 9,302,000 | 3.22% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 519,864 | 6,888,000 | 2.39% | ||
| 8 | Tekla Capital Management LLC | 500,324 | 6,629,000 | 2.30% | ||
| 9 | STATE STREET CORP | 341,161 | 4,521,000 | 1.57% | ||
| 10 | NORTHERN TRUST CORP | 249,661 | 3,307,000 | 1.15% | ||
| 11 | JPMORGAN CHASE & CO | 217,237 | 2,878,000 | 1.00% | ||
| 12 | BAKER BROS. ADVISORS LP | 216,990 | 2,875,000 | 1.00% | ||
| 13 | Candriam S.C.A. | 191,100 | 2,532,000 | 0.88% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 173,456 | 2,298,000 | 0.80% | ||
| 15 | First Light Asset Management, LLC | 152,765 | 2,024,000 | 0.70% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 138,644 | 1,836,000 | 0.64% | ||
| 17 | WELLS FARGO & COMPANY/MN | 134,886 | 1,787,000 | 0.62% | ||
| 18 | GUGGENHEIM CAPITAL LLC | 115,273 | 1,528,000 | 0.53% | ||
| 19 | STONERIDGE INVESTMENT PARTNERS LLC | 106,809 | 1,415,000 | 0.49% | ||
| 20 | Bank of New York Mellon Corp | 104,297 | 1,382,000 | 0.48% | ||
| 21 | DEUTSCHE BANK AG\ | 103,950 | 1,375,000 | 0.48% | ||
| 22 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 88,066 | 1,167,000 | 0.40% | ||
| 23 | NEW YORK STATE COMMON RETIREMENT FUND | 81,226 | 1,076,000 | 0.37% | ||
| 24 | BlackRock Investment Management, LLC | 80,305 | 1,064,000 | 0.37% | ||
| 25 | A.R.T. Advisors, LLC | 76,950 | 1,019,000 | 0.35% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,208 | 1,010,000 | 0.35% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 72,986 | 967,000 | 0.33% | ||
| 28 | Opus Point Partners Management, LLC | 60,000 | 795,000 | 0.28% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 58,545 | 776,000 | 0.27% | ||
| 30 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 49,900 | 661,000 | 0.23% | Call | |
| 31 | D. E. Shaw & Co., Inc. | 47,700 | 632,000 | 0.22% | ||
| 32 | CREDIT SUISSE AG/ | 47,579 | 630,000 | 0.22% | ||
| 33 | ALPS ADVISORS INC | 47,071 | 624,000 | 0.22% | ||
| 34 | TCW GROUP INC | 44,986 | 596,000 | 0.21% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,832 | 568,000 | 0.20% | ||
| 36 | ROYAL BANK OF CANADA | 41,474 | 549,000 | 0.19% | ||
| 37 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 41,300 | 547,000 | 0.19% | Put | |
| 38 | Connor, Clark & Lunn Investment Management Ltd. | 41,100 | 545,000 | 0.19% | ||
| 39 | ROYAL BANK OF CANADA | 40,000 | 530,000 | 0.18% | Call | |
| 40 | ROYAL BANK OF CANADA | 40,000 | 530,000 | 0.18% | Put | |
| 41 | Trexquant Investment LP | 39,900 | 529,000 | 0.18% | ||
| 42 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 38,661 | 512,000 | 0.18% | ||
| 43 | TEACHERS ADVISORS, LLC | 36,532 | 484,000 | 0.17% | ||
| 44 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 35,524 | 470,000 | 0.16% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,800 | 448,000 | 0.16% | Put | |
| 46 | ProShare Advisors LLC | 32,097 | 425,000 | 0.15% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,679 | 420,000 | 0.15% | ||
| 48 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 30,000 | 398,000 | 0.14% | ||
| 49 | Swiss National Bank | 27,900 | 370,000 | 0.13% | ||
| 50 | PEAK6 Group LLC | 27,400 | 363,000 | 0.13% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
