| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,179,416 | 158,542,000 | 24.67% | ||
| 2 | FRANKLIN RESOURCES INC | 4,849,252 | 148,434,000 | 23.09% | ||
| 3 | PFM Health Sciences, LP | 1,124,056 | 34,407,000 | 5.35% | ||
| 4 | STATE STREET CORP | 987,269 | 30,217,000 | 4.70% | ||
| 5 | Palo Alto Investors LP | 951,032 | 29,111,000 | 4.53% | ||
| 6 | BlackRock Fund Advisors | 869,544 | 26,617,000 | 4.14% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 707,268 | 21,649,000 | 3.37% | ||
| 8 | VANGUARD GROUP INC | 562,049 | 17,204,000 | 2.68% | ||
| 9 | Tekla Capital Management LLC | 476,966 | 14,600,000 | 2.27% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 425,106 | 13,012,000 | 2.02% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 409,251 | 12,527,000 | 1.95% | ||
| 12 | Cormorant Asset Management, LP | 300,987 | 9,213,000 | 1.43% | ||
| 13 | BLACKROCK ADVISORS LLC | 278,752 | 8,533,000 | 1.33% | ||
| 14 | Candriam S.C.A. | 269,000 | 8,236,000 | 1.28% | ||
| 15 | BAKER BROS. ADVISORS LP | 216,990 | 6,642,000 | 1.03% | ||
| 16 | CI Global Investments Inc. | 200,000 | 6,122,000 | 0.95% | ||
| 17 | WELLINGTON MANAGEMENT GROUP LLP | 175,886 | 5,384,000 | 0.84% | ||
| 18 | NORTHERN TRUST CORP | 171,053 | 5,236,000 | 0.81% | ||
| 19 | Allianz Asset Management GmbH | 157,683 | 4,827,000 | 0.75% | ||
| 20 | PointState Capital LP | 150,000 | 4,592,000 | 0.71% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 148,792 | 4,555,000 | 0.71% | ||
| 22 | TCW GROUP INC | 138,885 | 4,252,000 | 0.66% | ||
| 23 | GUGGENHEIM CAPITAL LLC | 130,760 | 4,002,000 | 0.62% | ||
| 24 | New Leaf Venture Partners, L.L.C. | 126,687 | 3,878,000 | 0.60% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 123,113 | 3,768,000 | 0.59% | ||
| 26 | LORD, ABBETT & CO. LLC | 116,599 | 3,569,000 | 0.56% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 111,600 | 3,416,000 | 0.53% | ||
| 28 | DEUTSCHE BANK AG\ | 108,581 | 3,322,000 | 0.52% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 96,114 | 2,942,000 | 0.46% | ||
| 30 | UBS Group AG | 88,242 | 2,701,000 | 0.42% | ||
| 31 | Bank of New York Mellon Corp | 81,144 | 2,484,000 | 0.39% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,400 | 2,277,000 | 0.35% | Put | |
| 33 | TEACHERS ADVISORS, LLC | 73,717 | 2,256,000 | 0.35% | ||
| 34 | BlackRock Investment Management, LLC | 60,669 | 1,857,000 | 0.29% | ||
| 35 | MORGAN STANLEY | 57,740 | 1,768,000 | 0.28% | ||
| 36 | PICTET ASSET MANAGEMENT LTD | 62,200 | 1,689,000 | 0.26% | ||
| 37 | GOLDMAN SACHS GROUP INC | 52,541 | 1,608,000 | 0.25% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 51,750 | 1,584,000 | 0.25% | ||
| 39 | GOLDMAN SACHS GROUP INC | 50,000 | 1,531,000 | 0.24% | Call | |
| 40 | GOLDMAN SACHS GROUP INC | 50,000 | 1,531,000 | 0.24% | Put | |
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,145 | 1,505,000 | 0.23% | ||
| 42 | JPMORGAN CHASE & CO | 47,505 | 1,454,000 | 0.23% | ||
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 44,100 | 1,350,000 | 0.21% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,752 | 1,339,000 | 0.21% | ||
| 45 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 39,487 | 1,209,000 | 0.19% | ||
| 46 | WOODSTOCK CORP | 38,989 | 1,193,000 | 0.19% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,400 | 1,084,000 | 0.17% | Call | |
| 48 | ProShare Advisors LLC | 31,580 | 967,000 | 0.15% | ||
| 49 | CREDIT SUISSE AG/ | 29,500 | 903,000 | 0.14% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,037 | 828,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
