| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 4,420,010 | 154,433,000 | 26.12% | ||
| 2 | FMR LLC | 4,059,045 | 141,823,000 | 23.99% | ||
| 3 | PFM Health Sciences, LP | 1,125,854 | 39,337,000 | 6.65% | ||
| 4 | Foresite Capital Management I, LLC | 1,077,124 | 37,635,000 | 6.37% | ||
| 5 | BLACKROCK ADVISORS LLC | 724,165 | 25,303,000 | 4.28% | ||
| 6 | STATE STREET CORP | 566,202 | 19,775,000 | 3.35% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 488,342 | 17,063,000 | 2.89% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 472,146 | 16,497,000 | 2.79% | ||
| 9 | Cormorant Asset Management, LP | 385,000 | 13,452,000 | 2.28% | ||
| 10 | VANGUARD GROUP INC | 381,197 | 13,319,000 | 2.25% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 328,026 | 11,462,000 | 1.94% | ||
| 12 | BlackRock Fund Advisors | 322,396 | 11,265,000 | 1.91% | ||
| 13 | BlackRock Group LTD | 230,817 | 8,065,000 | 1.36% | ||
| 14 | LORD, ABBETT & CO. LLC | 166,870 | 5,830,000 | 0.99% | ||
| 15 | NORTHERN TRUST CORP | 151,240 | 5,284,000 | 0.89% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 141,013 | 4,927,000 | 0.83% | ||
| 17 | TCW GROUP INC | 137,103 | 4,790,000 | 0.81% | ||
| 18 | BlackRock Finance, Inc. | 102,655 | 3,587,000 | 0.61% | ||
| 19 | Tekla Capital Management LLC | 101,966 | 3,563,000 | 0.60% | ||
| 20 | PointState Capital LP | 100,000 | 3,494,000 | 0.59% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 99,631 | 3,481,000 | 0.59% | ||
| 22 | BAKER BROS. ADVISORS LP | 94,095 | 3,288,000 | 0.56% | ||
| 23 | GUGGENHEIM CAPITAL LLC | 85,143 | 2,975,000 | 0.50% | ||
| 24 | DEUTSCHE BANK AG\ | 80,047 | 2,795,000 | 0.47% | ||
| 25 | DRIEHAUS CAPITAL MANAGEMENT LLC | 78,851 | 2,755,000 | 0.47% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 77,658 | 2,713,000 | 0.46% | ||
| 27 | TEACHERS ADVISORS, LLC | 70,224 | 2,454,000 | 0.42% | ||
| 28 | BlackRock Investment Management, LLC | 69,783 | 2,438,000 | 0.41% | ||
| 29 | EverPoint Asset Management, LLC | 64,852 | 2,266,000 | 0.38% | ||
| 30 | Bank of New York Mellon Corp | 62,885 | 2,197,000 | 0.37% | ||
| 31 | JPMORGAN CHASE & CO | 54,550 | 1,906,000 | 0.32% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,500 | 1,799,000 | 0.30% | Put | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,500 | 1,730,000 | 0.29% | Call | |
| 34 | MORGAN STANLEY | 48,537 | 1,696,000 | 0.29% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 46,649 | 1,630,000 | 0.28% | ||
| 36 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 39,980 | 1,397,000 | 0.24% | ||
| 37 | Point72 Asset Management, L.P. | 39,400 | 1,377,000 | 0.23% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 35,200 | 1,230,000 | 0.21% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,657 | 1,072,000 | 0.18% | ||
| 40 | EVENTIDE ASSET MANAGEMENT, LLC | 30,000 | 1,048,000 | 0.18% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,030 | 875,000 | 0.15% | ||
| 42 | Partner Investment Management, L.P. | 21,560 | 753,000 | 0.13% | ||
| 43 | Aperio Group, LLC | 20,421 | 714,000 | 0.12% | ||
| 44 | Swiss National Bank | 19,600 | 685,000 | 0.12% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 16,718 | 584,000 | 0.10% | ||
| 46 | UBS AG | 15,962 | 558,000 | 0.09% | ||
| 47 | Nationwide Fund Advisors | 10,345 | 361,000 | 0.06% | ||
| 48 | RHUMBLINE ADVISERS | 10,240 | 358,000 | 0.06% | ||
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 9,793 | 342,000 | 0.06% | ||
| 50 | GOLDMAN SACHS GROUP INC | 9,555 | 334,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
