| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,283,732 | 98,697,000 | 33.04% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,511,645 | 33,905,000 | 11.35% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,046,402 | 24,109,000 | 8.07% | ||
| 4 | Redmile Group, LLC | 860,809 | 17,269,000 | 5.78% | ||
| 5 | JENNISON ASSOCIATES LLC | 751,106 | 16,830,000 | 5.63% | ||
| 6 | JPMORGAN CHASE & CO | 497,573 | 11,464,000 | 3.84% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 1,026,402 | 9,337,000 | 3.13% | ||
| 8 | CITADEL ADVISORS LLC | 338,526 | 7,799,000 | 2.61% | ||
| 9 | SABBY MANAGEMENT, LLC | 331,515 | 7,638,000 | 2.56% | ||
| 10 | PointState Capital LP | 250,000 | 5,760,000 | 1.93% | ||
| 11 | Avoro Capital Advisors LLC | 220,000 | 5,069,000 | 1.70% | ||
| 12 | EMERALD ADVISERS, LLC | 198,202 | 4,567,000 | 1.53% | ||
| 13 | Point72 Asset Management, L.P. | 192,000 | 4,424,000 | 1.48% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 170,000 | 3,917,000 | 1.31% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 167,210 | 3,853,000 | 1.29% | ||
| 16 | MORGAN STANLEY | 150,274 | 3,463,000 | 1.16% | ||
| 17 | FRANKLIN RESOURCES INC | 150,000 | 3,456,000 | 1.16% | ||
| 18 | FEDERATED HERMES, INC. | 125,000 | 2,880,000 | 0.96% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 107,162 | 2,469,000 | 0.83% | ||
| 20 | Laurion Capital Management LP | 101,000 | 2,327,000 | 0.78% | ||
| 21 | DEUTSCHE BANK AG\ | 99,091 | 2,281,000 | 0.76% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 90,700 | 2,090,000 | 0.70% | ||
| 23 | MARSHALL WACE, LLP | 79,353 | 1,828,000 | 0.61% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 75,583 | 1,742,000 | 0.58% | ||
| 25 | Ghost Tree Capital, LLC | 75,000 | 1,728,000 | 0.58% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 69,857 | 1,610,000 | 0.54% | ||
| 27 | VANGUARD GROUP INC | 65,000 | 1,498,000 | 0.50% | ||
| 28 | JANE STREET GROUP, LLC | 60,220 | 1,387,000 | 0.46% | ||
| 29 | Cormorant Asset Management, LP | 60,000 | 1,382,000 | 0.46% | ||
| 30 | Tekla Capital Management LLC | 60,000 | 1,382,000 | 0.46% | ||
| 31 | Weiss Multi-Strategy Advisers LLC | 50,000 | 1,152,000 | 0.39% | ||
| 32 | GREAT POINT PARTNERS LLC | 50,000 | 1,152,000 | 0.39% | ||
| 33 | Alyeska Investment Group, L.P. | 49,091 | 1,131,000 | 0.38% | ||
| 34 | ACUTA CAPITAL PARTNERS, LLC | 45,750 | 1,054,000 | 0.35% | ||
| 35 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,240 | 1,042,000 | 0.35% | ||
| 36 | HealthCor Management, L.P. | 40,586 | 935,000 | 0.31% | ||
| 37 | GOLDMAN SACHS GROUP INC | 36,750 | 847,000 | 0.28% | ||
| 38 | Rock Springs Capital Management LP | 35,000 | 806,000 | 0.27% | ||
| 39 | NORGES BANK | 30,000 | 691,000 | 0.23% | ||
| 40 | SOROS FUND MANAGEMENT LLC | 27,000 | 622,000 | 0.21% | ||
| 41 | PUTNAM INVESTMENTS LLC | 25,559 | 589,000 | 0.20% | ||
| 42 | Endurant Capital Management LP | 20,547 | 473,000 | 0.16% | ||
| 43 | UBS Group AG | 17,207 | 397,000 | 0.13% | ||
| 44 | Quantitative Systematic Strategies LLC | 13,968 | 323,000 | 0.11% | ||
| 45 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 14,000 | 323,000 | 0.11% | ||
| 46 | TD ASSET MANAGEMENT INC | 10,500 | 242,000 | 0.08% | ||
| 47 | ArrowMark Colorado Holdings LLC | 10,000 | 230,000 | 0.08% | ||
| 48 | TUDOR INVESTMENT CORP ET AL | 10,000 | 230,000 | 0.08% | ||
| 49 | Highlander Capital Management, LLC | 6,500 | 150,000 | 0.05% | ||
| 50 | FNY Managed Accounts LLC | 4,000 | 92,160 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
