| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,190,594 | 97,096,000 | 30.22% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,528,231 | 34,481,000 | 10.73% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,046,402 | 24,245,000 | 7.54% | ||
| 4 | JPMORGAN CHASE & CO | 864,699 | 20,036,000 | 6.24% | ||
| 5 | JENNISON ASSOCIATES LLC | 656,434 | 14,989,000 | 4.66% | ||
| 6 | FRANKLIN RESOURCES INC | 620,100 | 14,368,000 | 4.47% | ||
| 7 | Avoro Capital Advisors LLC | 475,015 | 11,006,000 | 3.42% | ||
| 8 | Redmile Group, LLC | 445,221 | 9,284,000 | 2.89% | ||
| 9 | Point72 Asset Management, L.P. | 368,100 | 8,529,000 | 2.65% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 259,861 | 6,021,000 | 1.87% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 249,567 | 5,693,000 | 1.77% | ||
| 12 | CITADEL ADVISORS LLC | 235,249 | 5,451,000 | 1.70% | ||
| 13 | BlackRock Fund Advisors | 234,000 | 5,422,000 | 1.69% | ||
| 14 | SABBY MANAGEMENT, LLC | 231,515 | 5,364,000 | 1.67% | ||
| 15 | RA CAPITAL MANAGEMENT, L.P. | 225,000 | 5,213,000 | 1.62% | ||
| 16 | VANGUARD GROUP INC | 219,167 | 5,078,000 | 1.58% | ||
| 17 | EMERALD ADVISERS, LLC | 197,982 | 4,969,000 | 1.55% | ||
| 18 | PointState Capital LP | 200,000 | 4,634,000 | 1.44% | ||
| 19 | EMERALD MUTUAL FUND ADVISERS TRUST | 164,710 | 4,134,000 | 1.29% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 97,708 | 2,264,000 | 0.70% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 89,700 | 2,078,000 | 0.65% | ||
| 22 | Green Owl Capital Management, LLC | 81,000 | 1,877,000 | 0.58% | ||
| 23 | GLG LLC | 77,767 | 1,802,000 | 0.56% | ||
| 24 | PANAGORA ASSET MANAGEMENT INC | 77,742 | 1,801,000 | 0.56% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 74,509 | 1,726,000 | 0.54% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 69,857 | 1,619,000 | 0.50% | ||
| 27 | DEUTSCHE BANK AG\ | 61,000 | 1,412,000 | 0.44% | ||
| 28 | Tekla Capital Management LLC | 60,000 | 1,390,000 | 0.43% | ||
| 29 | EverPoint Asset Management, LLC | 53,072 | 1,230,000 | 0.38% | ||
| 30 | Cormorant Asset Management, LP | 51,000 | 1,182,000 | 0.37% | ||
| 31 | GREAT POINT PARTNERS LLC | 50,000 | 1,159,000 | 0.36% | ||
| 32 | Weiss Multi-Strategy Advisers LLC | 50,000 | 1,159,000 | 0.36% | ||
| 33 | First Eagle Investment Management, LLC | 50,000 | 1,159,000 | 0.36% | ||
| 34 | STATE STREET CORP | 47,694 | 1,106,000 | 0.34% | ||
| 35 | EMORY UNIVERSITY | 45,261 | 1,049,000 | 0.33% | ||
| 36 | ACUTA CAPITAL PARTNERS, LLC | 43,986 | 1,019,000 | 0.32% | ||
| 37 | Lamond Capital Partners LLC | 37,000 | 857,000 | 0.27% | ||
| 38 | MORGAN STANLEY | 33,539 | 777,000 | 0.24% | ||
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 32,250 | 747,000 | 0.23% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,016 | 719,000 | 0.22% | ||
| 41 | SOROS FUND MANAGEMENT LLC | 27,000 | 626,000 | 0.19% | ||
| 42 | PUTNAM INVESTMENTS LLC | 25,559 | 592,000 | 0.18% | ||
| 43 | BlackRock Investment Management, LLC | 24,887 | 577,000 | 0.18% | ||
| 44 | Bank of New York Mellon Corp | 23,496 | 544,000 | 0.17% | ||
| 45 | CITIGROUP INC | 21,841 | 507,000 | 0.16% | ||
| 46 | NORTHERN TRUST CORP | 21,436 | 496,000 | 0.15% | ||
| 47 | CORRADO ADVISORS, LLC | 16,950 | 393,000 | 0.12% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,900 | 392,000 | 0.12% | Put | |
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 16,633 | 385,000 | 0.12% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,400 | 357,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
