| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,865,647 | 66,270,000 | 24.78% | ||
| 2 | FMR LLC | 3,434,964 | 46,784,000 | 17.49% | ||
| 3 | JPMORGAN CHASE & CO | 2,124,601 | 28,937,000 | 10.82% | ||
| 4 | BlackRock Fund Advisors | 1,057,512 | 14,403,000 | 5.39% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 984,543 | 13,409,000 | 5.01% | ||
| 6 | VANGUARD GROUP INC | 901,431 | 12,278,000 | 4.59% | ||
| 7 | First Eagle Investment Management, LLC | 775,254 | 10,559,000 | 3.95% | ||
| 8 | FRANKLIN RESOURCES INC | 651,800 | 8,878,000 | 3.32% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 513,443 | 6,993,000 | 2.61% | ||
| 10 | KENNEDY CAPITAL MANAGEMENT LLC | 478,465 | 6,517,000 | 2.44% | ||
| 11 | MORGAN STANLEY | 430,473 | 5,863,000 | 2.19% | ||
| 12 | QVT Financial LP | 337,923 | 4,603,000 | 1.72% | ||
| 13 | STATE STREET CORP | 326,037 | 4,442,000 | 1.66% | ||
| 14 | NORTHERN TRUST CORP | 262,239 | 3,572,000 | 1.34% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 3,405,000 | 1.27% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 151,811 | 2,067,000 | 0.77% | ||
| 17 | AMERIPRISE FINANCIAL INC | 148,546 | 2,023,000 | 0.76% | ||
| 18 | EMORY UNIVERSITY | 95,215 | 1,297,000 | 0.48% | ||
| 19 | Bank of New York Mellon Corp | 94,999 | 1,295,000 | 0.48% | ||
| 20 | BlackRock Investment Management, LLC | 82,959 | 1,130,000 | 0.42% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 82,900 | 1,129,000 | 0.42% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 82,728 | 1,127,000 | 0.42% | ||
| 23 | SUFFOLK CAPITAL MANAGEMENT LLC | 82,538 | 1,124,000 | 0.42% | ||
| 24 | MCDANIEL TERRY & CO | 76,112 | 1,037,000 | 0.39% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,604 | 1,030,000 | 0.39% | ||
| 26 | Invesco Ltd. | 73,252 | 998,000 | 0.37% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,562 | 948,000 | 0.35% | ||
| 28 | Creative Planning | 69,100 | 941,000 | 0.35% | ||
| 29 | DEUTSCHE BANK AG\ | 65,200 | 886,000 | 0.33% | ||
| 30 | Tekla Capital Management LLC | 60,000 | 817,000 | 0.31% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,517 | 811,000 | 0.30% | ||
| 32 | Vident Investment Advisory, LLC | 47,157 | 642,000 | 0.24% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 47,000 | 640,000 | 0.24% | ||
| 34 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 44,716 | 609,000 | 0.23% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,246 | 589,000 | 0.22% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 42,633 | 581,000 | 0.22% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,100 | 573,000 | 0.21% | Put | |
| 38 | WELLS FARGO & COMPANY/MN | 39,839 | 543,000 | 0.20% | ||
| 39 | CREDIT SUISSE AG/ | 38,013 | 518,000 | 0.19% | ||
| 40 | D.A. DAVIDSON & CO. | 36,050 | 491,000 | 0.18% | ||
| 41 | TEACHERS ADVISORS, LLC | 35,608 | 485,000 | 0.18% | ||
| 42 | WASATCH ADVISORS LP | 30,525 | 416,000 | 0.16% | ||
| 43 | Swiss National Bank | 29,300 | 399,000 | 0.15% | ||
| 44 | GOLDMAN SACHS GROUP INC | 28,801 | 392,000 | 0.15% | ||
| 45 | TD ASSET MANAGEMENT INC | 28,579 | 389,000 | 0.15% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,700 | 350,000 | 0.13% | Call | |
| 47 | RHUMBLINE ADVISERS | 22,858 | 311,000 | 0.12% | ||
| 48 | Allianz Asset Management GmbH | 21,836 | 297,000 | 0.11% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 21,400 | 291,000 | 0.11% | ||
| 50 | ProShare Advisors LLC | 21,275 | 290,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
