| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,190,594 | 89,134,000 | 27.57% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,452,128 | 30,887,000 | 9.55% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,026,402 | 21,832,000 | 6.75% | ||
| 4 | FMR LLC | 1,000,000 | 21,270,000 | 6.58% | ||
| 5 | JPMORGAN CHASE & CO | 924,357 | 19,660,000 | 6.08% | ||
| 6 | FRANKLIN RESOURCES INC | 850,300 | 18,086,000 | 5.59% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 526,583 | 11,200,000 | 3.46% | ||
| 8 | Point72 Asset Management, L.P. | 505,200 | 10,746,000 | 3.32% | ||
| 9 | CITADEL ADVISORS LLC | 449,488 | 9,561,000 | 2.96% | ||
| 10 | VANGUARD GROUP INC | 280,148 | 5,959,000 | 1.84% | ||
| 11 | JENNISON ASSOCIATES LLC | 275,725 | 5,865,000 | 1.81% | ||
| 12 | Avoro Capital Advisors LLC | 262,515 | 5,584,000 | 1.73% | ||
| 13 | SABBY MANAGEMENT, LLC | 241,039 | 5,127,000 | 1.59% | ||
| 14 | Redmile Group, LLC | 238,121 | 5,065,000 | 1.57% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 231,514 | 4,924,000 | 1.52% | ||
| 16 | PointState Capital LP | 225,000 | 4,786,000 | 1.48% | ||
| 17 | BlackRock Fund Advisors | 220,886 | 4,698,000 | 1.45% | ||
| 18 | EMERALD ADVISERS, LLC | 198,992 | 4,233,000 | 1.31% | ||
| 19 | EverPoint Asset Management, LLC | 165,000 | 3,510,000 | 1.09% | ||
| 20 | First Eagle Investment Management, LLC | 150,000 | 3,191,000 | 0.99% | ||
| 21 | EMERALD MUTUAL FUND ADVISERS TRUST | 145,380 | 3,092,000 | 0.96% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 135,349 | 2,879,000 | 0.89% | ||
| 23 | Spark Investment Management LLC | 110,500 | 2,350,000 | 0.73% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,100 | 2,065,000 | 0.64% | Put | |
| 25 | Green Owl Capital Management, LLC | 90,000 | 1,914,000 | 0.59% | ||
| 26 | DRIEHAUS CAPITAL MANAGEMENT LLC | 87,644 | 1,864,000 | 0.58% | ||
| 27 | NORTHERN TRUST CORP | 86,303 | 1,836,000 | 0.57% | ||
| 28 | DEUTSCHE BANK AG\ | 82,502 | 1,754,000 | 0.54% | ||
| 29 | GLG LLC | 82,086 | 1,746,000 | 0.54% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 75,286 | 1,601,000 | 0.50% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 74,573 | 1,586,000 | 0.49% | ||
| 32 | Lamond Capital Partners LLC | 68,780 | 1,463,000 | 0.45% | ||
| 33 | Tekla Capital Management LLC | 60,000 | 1,276,000 | 0.39% | ||
| 34 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 47,225 | 1,004,000 | 0.31% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,127 | 939,000 | 0.29% | ||
| 36 | Bank of New York Mellon Corp | 39,923 | 849,000 | 0.26% | ||
| 37 | MORGAN STANLEY | 38,459 | 818,000 | 0.25% | ||
| 38 | TD ASSET MANAGEMENT INC | 33,899 | 721,000 | 0.22% | ||
| 39 | BlackRock Investment Management, LLC | 30,149 | 641,000 | 0.20% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,620 | 587,000 | 0.18% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,700 | 568,000 | 0.18% | Call | |
| 42 | PUTNAM INVESTMENTS LLC | 25,559 | 544,000 | 0.17% | ||
| 43 | WASATCH ADVISORS LP | 25,304 | 538,000 | 0.17% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,902 | 466,000 | 0.14% | ||
| 45 | Highlander Capital Management, LLC | 19,250 | 409,000 | 0.13% | ||
| 46 | CORRADO ADVISORS, LLC | 17,050 | 363,000 | 0.11% | ||
| 47 | Zurcher Kantonalbank (Zurich Cantonalbank) | 15,702 | 334,000 | 0.10% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,108 | 321,000 | 0.10% | ||
| 49 | Jefferies Group LLC | 15,000 | 319,000 | 0.10% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 13,600 | 289,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
