| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,865,647 | 98,627,000 | 29.76% | ||
| 2 | FMR LLC | 1,896,454 | 38,441,000 | 11.60% | ||
| 3 | JPMORGAN CHASE & CO | 1,821,287 | 36,918,000 | 11.14% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,173,486 | 23,787,000 | 7.18% | ||
| 5 | FRANKLIN RESOURCES INC | 686,500 | 13,915,000 | 4.20% | ||
| 6 | VANGUARD GROUP INC | 655,682 | 13,290,000 | 4.01% | ||
| 7 | BlackRock Fund Advisors | 535,292 | 10,850,000 | 3.27% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 429,188 | 8,700,000 | 2.63% | ||
| 9 | MORGAN STANLEY | 426,861 | 8,653,000 | 2.61% | ||
| 10 | QVT Financial LP | 340,986 | 6,912,000 | 2.09% | ||
| 11 | First Eagle Investment Management, LLC | 302,489 | 6,131,000 | 1.85% | ||
| 12 | Cormorant Asset Management, LP | 300,000 | 6,081,000 | 1.83% | ||
| 13 | EverPoint Asset Management, LLC | 265,000 | 5,372,000 | 1.62% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 231,515 | 4,693,000 | 1.42% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 224,252 | 4,546,000 | 1.37% | ||
| 16 | GOLDMAN SACHS GROUP INC | 200,000 | 4,054,000 | 1.22% | Call | |
| 17 | Point72 Asset Management, L.P. | 166,400 | 3,373,000 | 1.02% | ||
| 18 | KENNEDY CAPITAL MANAGEMENT LLC | 143,588 | 2,911,000 | 0.88% | ||
| 19 | STATE STREET CORP | 101,723 | 2,062,000 | 0.62% | ||
| 20 | NORTHERN TRUST CORP | 100,885 | 2,045,000 | 0.62% | ||
| 21 | GRATICULE ASIA MACRO ADVISORS LLC | 87,000 | 1,763,000 | 0.53% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85,700 | 1,737,000 | 0.52% | Put | |
| 23 | GOLDMAN SACHS GROUP INC | 77,220 | 1,565,000 | 0.47% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 75,719 | 1,535,000 | 0.46% | ||
| 25 | Zurcher Kantonalbank (Zurich Cantonalbank) | 70,454 | 1,428,000 | 0.43% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 62,152 | 1,259,000 | 0.38% | ||
| 27 | Tekla Capital Management LLC | 60,000 | 1,216,000 | 0.37% | ||
| 28 | PEAK6 Group LLC | 50,100 | 1,016,000 | 0.31% | Call | |
| 29 | DEUTSCHE BANK AG\ | 47,029 | 953,000 | 0.29% | ||
| 30 | Bank of New York Mellon Corp | 45,118 | 914,000 | 0.28% | ||
| 31 | A.R.T. Advisors, LLC | 42,878 | 869,000 | 0.26% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 41,600 | 843,000 | 0.25% | ||
| 33 | Vident Investment Advisory, LLC | 40,395 | 819,000 | 0.25% | ||
| 34 | TD ASSET MANAGEMENT INC | 35,678 | 723,000 | 0.22% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,472 | 699,000 | 0.21% | ||
| 36 | MCDANIEL TERRY & CO | 33,836 | 686,000 | 0.21% | ||
| 37 | Creative Planning | 30,300 | 614,000 | 0.19% | ||
| 38 | BlackRock Investment Management, LLC | 29,287 | 594,000 | 0.18% | ||
| 39 | Swiss National Bank | 28,900 | 586,000 | 0.18% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,620 | 560,000 | 0.17% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 26,425 | 536,000 | 0.16% | ||
| 42 | CITADEL ADVISORS LLC | 26,419 | 536,000 | 0.16% | ||
| 43 | PUTNAM INVESTMENTS LLC | 25,559 | 518,000 | 0.16% | ||
| 44 | Weiss Multi-Strategy Advisers LLC | 25,500 | 517,000 | 0.16% | ||
| 45 | WASATCH ADVISORS LP | 25,394 | 515,000 | 0.16% | ||
| 46 | Trexquant Investment LP | 25,353 | 514,000 | 0.16% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,753 | 482,000 | 0.15% | ||
| 48 | ProShare Advisors LLC | 22,515 | 456,000 | 0.14% | ||
| 49 | CREDIT SUISSE AG/ | 21,549 | 437,000 | 0.13% | ||
| 50 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 20,325 | 412,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
