| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,865,647 | 96,826,000 | 25.97% | ||
| 2 | FMR LLC | 3,444,606 | 68,548,000 | 18.38% | ||
| 3 | JPMORGAN CHASE & CO | 2,234,064 | 44,459,000 | 11.92% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,172,862 | 23,340,000 | 6.26% | ||
| 5 | BlackRock Fund Advisors | 945,216 | 18,810,000 | 5.04% | ||
| 6 | VANGUARD GROUP INC | 875,053 | 17,414,000 | 4.67% | ||
| 7 | First Eagle Investment Management, LLC | 854,055 | 16,996,000 | 4.56% | ||
| 8 | FRANKLIN RESOURCES INC | 686,500 | 13,661,000 | 3.66% | ||
| 9 | MORGAN STANLEY | 441,501 | 8,786,000 | 2.36% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 396,384 | 7,888,000 | 2.12% | ||
| 11 | QVT Financial LP | 388,839 | 7,738,000 | 2.08% | ||
| 12 | STATE STREET CORP | 310,895 | 6,188,000 | 1.66% | ||
| 13 | KENNEDY CAPITAL MANAGEMENT LLC | 262,426 | 5,222,000 | 1.40% | ||
| 14 | NORTHERN TRUST CORP | 252,766 | 5,030,000 | 1.35% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 164,638 | 3,276,000 | 0.88% | ||
| 16 | Zurcher Kantonalbank (Zurich Cantonalbank) | 105,126 | 2,092,000 | 0.56% | ||
| 17 | Bank of New York Mellon Corp | 86,386 | 1,719,000 | 0.46% | ||
| 18 | BlackRock Investment Management, LLC | 82,628 | 1,644,000 | 0.44% | ||
| 19 | PRINCIPAL FINANCIAL GROUP INC | 79,691 | 1,586,000 | 0.43% | ||
| 20 | MCDANIEL TERRY & CO | 79,612 | 1,584,000 | 0.42% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 66,176 | 1,317,000 | 0.35% | ||
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,866 | 1,311,000 | 0.35% | ||
| 23 | DEUTSCHE BANK AG\ | 64,442 | 1,281,000 | 0.34% | ||
| 24 | Tekla Capital Management LLC | 60,000 | 1,194,000 | 0.32% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,000 | 1,134,000 | 0.30% | Put | |
| 26 | Vident Investment Advisory, LLC | 53,229 | 1,059,000 | 0.28% | ||
| 27 | FRED ALGER MANAGEMENT, LLC | 50,000 | 995,000 | 0.27% | ||
| 28 | SUFFOLK CAPITAL MANAGEMENT LLC | 45,636 | 908,000 | 0.24% | ||
| 29 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,346 | 882,000 | 0.24% | ||
| 30 | TEACHERS ADVISORS, LLC | 33,764 | 672,000 | 0.18% | ||
| 31 | TD ASSET MANAGEMENT INC | 31,478 | 626,000 | 0.17% | ||
| 32 | WASATCH ADVISORS LP | 30,525 | 607,000 | 0.16% | ||
| 33 | Creative Planning | 30,300 | 603,000 | 0.16% | ||
| 34 | Swiss National Bank | 29,300 | 583,000 | 0.16% | ||
| 35 | CREDIT SUISSE AG/ | 27,158 | 540,000 | 0.14% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,100 | 519,000 | 0.14% | Call | |
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 21,400 | 426,000 | 0.11% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,802 | 414,000 | 0.11% | ||
| 39 | VIRTUS ETF ADVISERS LLC | 20,302 | 404,000 | 0.11% | ||
| 40 | RHUMBLINE ADVISERS | 19,494 | 388,000 | 0.10% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 19,400 | 386,000 | 0.10% | ||
| 42 | ProShare Advisors LLC | 19,124 | 381,000 | 0.10% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 17,500 | 348,000 | 0.09% | ||
| 44 | SIMPLEX TRADING, LLC | 17,210 | 342,000 | 0.09% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,330 | 285,000 | 0.08% | ||
| 46 | CITADEL ADVISORS LLC | 13,500 | 269,000 | 0.07% | Call | |
| 47 | Nationwide Fund Advisors | 13,468 | 268,000 | 0.07% | ||
| 48 | GOLDMAN SACHS GROUP INC | 12,424 | 247,000 | 0.07% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 12,082 | 240,432 | 0.06% | ||
| 50 | WELLS FARGO & COMPANY/MN | 11,525 | 229,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
