| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,190,594 | 60,889,000 | 27.10% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,416,386 | 20,580,000 | 9.16% | ||
| 3 | JPMORGAN CHASE & CO | 1,191,668 | 17,316,000 | 7.71% | ||
| 4 | FMR LLC | 1,000,000 | 14,530,000 | 6.47% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 992,616 | 14,423,000 | 6.42% | ||
| 6 | FRANKLIN RESOURCES INC | 713,500 | 10,367,000 | 4.61% | ||
| 7 | CITADEL ADVISORS LLC | 620,225 | 9,012,000 | 4.01% | ||
| 8 | VANGUARD GROUP INC | 589,115 | 8,560,000 | 3.81% | ||
| 9 | MORGAN STANLEY | 352,407 | 5,120,000 | 2.28% | ||
| 10 | QVT Financial LP | 317,742 | 4,617,000 | 2.05% | ||
| 11 | RA CAPITAL MANAGEMENT, L.P. | 315,704 | 4,587,000 | 2.04% | ||
| 12 | First Eagle Investment Management, LLC | 250,000 | 3,633,000 | 1.62% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 231,514 | 3,364,000 | 1.50% | ||
| 14 | BlackRock Fund Advisors | 221,543 | 3,219,000 | 1.43% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 220,884 | 3,209,000 | 1.43% | ||
| 16 | Ghost Tree Capital, LLC | 200,000 | 2,906,000 | 1.29% | ||
| 17 | PointState Capital LP | 200,000 | 2,906,000 | 1.29% | ||
| 18 | DEUTSCHE BANK AG\ | 166,070 | 2,412,000 | 1.07% | ||
| 19 | EMERALD ADVISERS, LLC | 154,180 | 2,240,000 | 1.00% | ||
| 20 | EMERALD MUTUAL FUND ADVISERS TRUST | 153,140 | 2,225,000 | 0.99% | ||
| 21 | KENNEDY CAPITAL MANAGEMENT LLC | 134,005 | 1,947,000 | 0.87% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,100 | 1,934,000 | 0.86% | Put | |
| 23 | SABBY MANAGEMENT, LLC | 120,094 | 1,745,000 | 0.78% | ||
| 24 | Green Owl Capital Management, LLC | 120,000 | 1,744,000 | 0.78% | ||
| 25 | NORTHERN TRUST CORP | 96,469 | 1,402,000 | 0.62% | ||
| 26 | Numeric Investors LLC | 93,861 | 1,364,000 | 0.61% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,200 | 1,136,000 | 0.51% | Call | |
| 28 | Spark Investment Management LLC | 76,200 | 1,107,000 | 0.49% | ||
| 29 | PRINCIPAL FINANCIAL GROUP INC | 75,581 | 1,099,000 | 0.49% | ||
| 30 | CQS Cayman LP | 74,736 | 1,086,000 | 0.48% | ||
| 31 | Zurcher Kantonalbank (Zurich Cantonalbank) | 67,343 | 978,000 | 0.44% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 62,698 | 911,000 | 0.41% | ||
| 33 | Tekla Capital Management LLC | 60,000 | 872,000 | 0.39% | ||
| 34 | TFS CAPITAL LLC | 59,068 | 858,000 | 0.38% | ||
| 35 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 50,225 | 730,000 | 0.32% | ||
| 36 | Bank of New York Mellon Corp | 49,419 | 719,000 | 0.32% | ||
| 37 | TD ASSET MANAGEMENT INC | 48,278 | 701,000 | 0.31% | ||
| 38 | Cubist Systematic Strategies, LLC | 42,874 | 623,000 | 0.28% | ||
| 39 | Swiss National Bank | 28,900 | 420,000 | 0.19% | ||
| 40 | BlackRock Investment Management, LLC | 28,730 | 417,000 | 0.19% | ||
| 41 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 27,959 | 406,000 | 0.18% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,620 | 401,000 | 0.18% | ||
| 43 | PDT Partners, LLC | 27,023 | 393,000 | 0.17% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,600 | 386,000 | 0.17% | ||
| 45 | PUTNAM INVESTMENTS LLC | 25,559 | 371,000 | 0.17% | ||
| 46 | WASATCH ADVISORS LP | 25,304 | 368,000 | 0.16% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,233 | 338,000 | 0.15% | ||
| 48 | Highlander Capital Management, LLC | 20,750 | 301,000 | 0.13% | ||
| 49 | Weiss Multi-Strategy Advisers LLC | 20,500 | 298,000 | 0.13% | ||
| 50 | GRATICULE ASIA MACRO ADVISORS LLC | 18,000 | 262,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
