| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 4,865,647 | 45,494,000 | 30.49% | ||
| 2 | JPMORGAN CHASE & CO | 2,438,169 | 22,797,000 | 15.28% | ||
| 3 | FMR LLC | 1,235,000 | 11,547,000 | 7.74% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,141,436 | 10,672,000 | 7.15% | ||
| 5 | VANGUARD GROUP INC | 687,239 | 6,425,000 | 4.31% | ||
| 6 | FRANKLIN RESOURCES INC | 686,500 | 6,419,000 | 4.30% | ||
| 7 | First Eagle Investment Management, LLC | 588,207 | 5,500,000 | 3.69% | ||
| 8 | BlackRock Fund Advisors | 557,813 | 5,216,000 | 3.50% | ||
| 9 | QVT Financial LP | 507,939 | 4,749,000 | 3.18% | ||
| 10 | MORGAN STANLEY | 413,672 | 3,867,000 | 2.59% | ||
| 11 | Cormorant Asset Management, LP | 300,000 | 2,805,000 | 1.88% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 275,982 | 2,580,000 | 1.73% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 222,481 | 2,080,000 | 1.39% | ||
| 14 | FORESITE CAPITAL MANAGEMENT III, LLC | 205,990 | 1,926,000 | 1.29% | ||
| 15 | KENNEDY CAPITAL MANAGEMENT LLC | 176,334 | 1,649,000 | 1.11% | ||
| 16 | STATE STREET CORP | 112,395 | 1,051,000 | 0.70% | ||
| 17 | NORTHERN TRUST CORP | 100,911 | 943,000 | 0.63% | ||
| 18 | Zurcher Kantonalbank (Zurich Cantonalbank) | 100,621 | 941,000 | 0.63% | ||
| 19 | MCDANIEL TERRY & CO | 84,612 | 791,000 | 0.53% | ||
| 20 | SABBY MANAGEMENT, LLC | 77,020 | 720,000 | 0.48% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 73,200 | 684,000 | 0.46% | Put | |
| 22 | PRINCIPAL FINANCIAL GROUP INC | 72,032 | 674,000 | 0.45% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,808 | 643,000 | 0.43% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 64,665 | 604,000 | 0.40% | ||
| 25 | Tekla Capital Management LLC | 60,000 | 561,000 | 0.38% | ||
| 26 | Bank of New York Mellon Corp | 57,810 | 541,000 | 0.36% | ||
| 27 | DEUTSCHE BANK AG\ | 50,909 | 475,000 | 0.32% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 39,792 | 372,000 | 0.25% | ||
| 29 | FRED ALGER MANAGEMENT, LLC | 39,600 | 370,000 | 0.25% | ||
| 30 | Numeric Investors LLC | 37,109 | 347,000 | 0.23% | ||
| 31 | TD ASSET MANAGEMENT INC | 34,478 | 322,000 | 0.22% | ||
| 32 | Swiss National Bank | 35,300 | 319,000 | 0.21% | ||
| 33 | WASATCH ADVISORS LP | 35,569 | 312,000 | 0.21% | ||
| 34 | CREDIT SUISSE AG/ | 31,199 | 291,000 | 0.20% | ||
| 35 | Creative Planning | 30,700 | 287,000 | 0.19% | ||
| 36 | Weiss Multi-Strategy Advisers LLC | 30,000 | 281,000 | 0.19% | ||
| 37 | BlackRock Investment Management, LLC | 29,811 | 279,000 | 0.19% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,620 | 258,000 | 0.17% | ||
| 39 | TWO SIGMA ADVISERS, LP | 27,600 | 258,000 | 0.17% | ||
| 40 | PUTNAM INVESTMENTS LLC | 25,559 | 239,000 | 0.16% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,161 | 226,000 | 0.15% | ||
| 42 | ProShare Advisors LLC | 20,491 | 192,000 | 0.13% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,768 | 166,000 | 0.11% | ||
| 44 | CUTLER GROUP LLC / CA | 16,621 | 155,000 | 0.10% | ||
| 45 | CITADEL ADVISORS LLC | 15,888 | 149,000 | 0.10% | ||
| 46 | Trexquant Investment LP | 15,735 | 147,000 | 0.10% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 15,600 | 146,000 | 0.10% | ||
| 48 | VIRTUS ETF ADVISERS LLC | 14,202 | 133,000 | 0.09% | ||
| 49 | Eagle Ridge Investment Management | 13,550 | 127,000 | 0.09% | ||
| 50 | DekaBank Deutsche Girozentrale | 14,000 | 123,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
