| 1 |
ProQuest Associates IV LLC |
4,668,663 |
31,467,000 |
28.01% |
|
|
| 2 |
INVESTOR AB |
3,510,189 |
23,659,000 |
21.06% |
|
|
| 3 |
Aisling Capital LLC |
2,983,797 |
20,111,000 |
17.90% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,396,880 |
9,415,000 |
8.38% |
|
|
| 5 |
Invesco Ltd. |
654,682 |
4,412,000 |
3.93% |
|
|
| 6 |
RA CAPITAL MANAGEMENT, L.P. |
630,702 |
4,251,000 |
3.78% |
|
|
| 7 |
Opaleye Management Inc. |
385,000 |
2,595,000 |
2.31% |
|
|
| 8 |
ROYCE & ASSOCIATES LP |
297,582 |
2,006,000 |
1.79% |
|
|
| 9 |
BlackRock Fund Advisors |
273,435 |
1,843,000 |
1.64% |
|
|
| 10 |
Granahan Investment Management, LLC |
194,894 |
1,314,000 |
1.17% |
|
|
| 11 |
Cormorant Asset Management, LP |
182,053 |
1,227,000 |
1.09% |
|
|
| 12 |
ACUTA CAPITAL PARTNERS, LLC |
141,309 |
952,000 |
0.85% |
|
|
| 13 |
Informed Momentum Co LLC |
136,478 |
920,000 |
0.82% |
|
|
| 14 |
HIGHLAND CAPITAL MANAGEMENT LP |
135,716 |
915,000 |
0.81% |
|
|
| 15 |
NEA Management Company, LLC |
133,488 |
900,000 |
0.80% |
|
|
| 16 |
MARSHALL WACE, LLP |
123,670 |
834,000 |
0.74% |
|
|
| 17 |
VANGUARD GROUP INC |
114,744 |
774,000 |
0.69% |
|
|
| 18 |
NORTHERN TRUST CORP |
102,752 |
692,000 |
0.62% |
|
|
| 19 |
STATE STREET CORP |
81,642 |
550,000 |
0.49% |
|
|
| 20 |
Sio Capital Management, LLC |
79,567 |
536,000 |
0.48% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
77,376 |
522,000 |
0.46% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
67,334 |
454,000 |
0.40% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
57,556 |
387,000 |
0.34% |
|
|
| 24 |
Bank of New York Mellon Corp |
41,773 |
282,000 |
0.25% |
|
|
| 25 |
BlackRock Investment Management, LLC |
36,310 |
245,000 |
0.22% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,575 |
220,000 |
0.20% |
|
|
| 27 |
CAXTON CORP |
23,035 |
155,000 |
0.14% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
18,913 |
127,000 |
0.11% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
14,904 |
100,000 |
0.09% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,462 |
91,000 |
0.08% |
|
|
| 31 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,400 |
63,000 |
0.06% |
|
|
| 32 |
MORGAN STANLEY |
7,979 |
53,000 |
0.05% |
|
|
| 33 |
Nationwide Fund Advisors |
6,560 |
44,000 |
0.04% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,107 |
41,000 |
0.04% |
|
|
| 35 |
ROYAL BANK OF CANADA |
5,252 |
35,000 |
0.03% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
5,082 |
34,000 |
0.03% |
|
|
| 37 |
UBS Group AG |
2,769 |
19,000 |
0.02% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
2,865 |
19,000 |
0.02% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
2,064 |
13,911 |
0.01% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
1,557 |
10,000 |
0.01% |
|
|
| 41 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,500 |
10,000 |
0.01% |
|
|
| 42 |
MSI Financial Services Inc |
1,000 |
7,000 |
0.01% |
|
|
| 43 |
Walleye Trading LLC |
1,100 |
7,000 |
0.01% |
|
|
| 44 |
Tower Research Capital LLC (TRC) |
844 |
6,000 |
0.01% |
|
|
| 45 |
CITIGROUP INC |
616 |
4,000 |
0.00% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
133 |
1,000 |
0.00% |
|
|
| 47 |
BANK OF AMERICA CORP /DE/ |
130 |
1,000 |
0.00% |
|
|
| 48 |
STRS OHIO |
0 |
0 |
0.00% |
|
|
| 49 |
BARCLAYS PLC |
55 |
0 |
0.00% |
|
|
