| 1 |
ProQuest Associates IV LLC |
5,062,363 |
28,856,000 |
21.64% |
|
|
| 2 |
INVESTOR AB |
3,510,189 |
20,008,000 |
15.00% |
|
|
| 3 |
CAXTON CORP |
2,123,567 |
12,104,000 |
9.08% |
|
|
| 4 |
Aisling Capital LLC |
1,804,933 |
10,288,000 |
7.72% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,700,000 |
9,690,000 |
7.27% |
|
|
| 6 |
VIVO CAPITAL, LLC |
1,513,975 |
8,630,000 |
6.47% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
1,358,600 |
7,744,000 |
5.81% |
|
|
| 8 |
Invesco Ltd. |
1,258,698 |
7,175,000 |
5.38% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
661,446 |
3,770,000 |
2.83% |
|
|
| 10 |
Cormorant Asset Management, LP |
563,880 |
3,214,000 |
2.41% |
|
|
| 11 |
VANGUARD GROUP INC |
445,579 |
2,539,000 |
1.90% |
|
|
| 12 |
BlackRock Fund Advisors |
434,071 |
2,474,000 |
1.86% |
|
|
| 13 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
398,000 |
2,269,000 |
1.70% |
|
|
| 14 |
ROYCE & ASSOCIATES LP |
322,582 |
1,839,000 |
1.38% |
|
|
| 15 |
EverPoint Asset Management, LLC |
200,000 |
1,140,000 |
0.85% |
|
|
| 16 |
PURA VIDA INVESTMENTS, LLC |
164,501 |
938,000 |
0.70% |
|
|
| 17 |
HIGHLAND CAPITAL MANAGEMENT LP |
142,724 |
813,000 |
0.61% |
|
|
| 18 |
STATE STREET CORP |
142,442 |
811,000 |
0.61% |
|
|
| 19 |
NORTHERN TRUST CORP |
141,928 |
809,000 |
0.61% |
|
|
| 20 |
NEEDHAM INVESTMENT MANAGEMENT LLC |
140,000 |
799,000 |
0.60% |
|
|
| 21 |
NEA Management Company, LLC |
133,488 |
761,000 |
0.57% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
116,940 |
666,000 |
0.50% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
116,334 |
663,000 |
0.50% |
|
|
| 24 |
Granahan Investment Management, LLC |
99,225 |
566,000 |
0.42% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
98,884 |
564,000 |
0.42% |
|
|
| 26 |
RENAISSANCE TECHNOLOGIES LLC |
64,000 |
365,000 |
0.27% |
|
|
| 27 |
Bank of New York Mellon Corp |
63,353 |
361,000 |
0.27% |
|
|
| 28 |
HAMILTON LANE ADVISORS LLC |
54,084 |
308,000 |
0.23% |
|
|
| 29 |
First Light Asset Management, LLC |
46,279 |
264,000 |
0.20% |
|
|
| 30 |
BlackRock Investment Management, LLC |
45,537 |
260,000 |
0.19% |
|
|
| 31 |
MORGAN STANLEY |
41,742 |
238,000 |
0.18% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,984 |
228,000 |
0.17% |
|
|
| 33 |
TFS CAPITAL LLC |
39,118 |
223,000 |
0.17% |
|
|
| 34 |
J. Goldman & Co LP |
36,000 |
205,000 |
0.15% |
|
|
| 35 |
RICE HALL JAMES & ASSOCIATES, LLC |
30,851 |
176,000 |
0.13% |
|
|
| 36 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
30,769 |
175,000 |
0.13% |
|
|
| 37 |
AlpInvest Partners B.V. |
27,693 |
158,000 |
0.12% |
|
|
| 38 |
PRICE T ROWE ASSOCIATES INC /MD/ |
27,730 |
158,000 |
0.12% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
27,334 |
156,000 |
0.12% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
21,222 |
121,000 |
0.09% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
19,401 |
111,000 |
0.08% |
|
|
| 42 |
JPMORGAN CHASE & CO |
18,632 |
106,000 |
0.08% |
|
|
| 43 |
Opaleye Management Inc. |
15,000 |
85,000 |
0.06% |
|
|
| 44 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,462 |
77,000 |
0.06% |
|
|
| 45 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,400 |
54,000 |
0.04% |
|
|
| 46 |
GLENMEDE TRUST CO NA |
9,323 |
53,000 |
0.04% |
|
|
| 47 |
Nationwide Fund Advisors |
7,976 |
45,000 |
0.03% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,635 |
44,000 |
0.03% |
|
|
| 49 |
DEUTSCHE BANK AG\ |
7,541 |
41,000 |
0.03% |
|
|
| 50 |
ROYAL BANK OF CANADA |
4,844 |
28,000 |
0.02% |
|
|
