| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 4,668,663 | 40,104,000 | 27.39% | ||
| 2 | INVESTOR AB | 3,510,189 | 30,153,000 | 20.59% | ||
| 3 | Aisling Capital LLC | 2,983,797 | 25,631,000 | 17.51% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,458,792 | 12,531,000 | 8.56% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,396,880 | 11,999,000 | 8.20% | ||
| 6 | Invesco Ltd. | 640,820 | 5,504,000 | 3.76% | ||
| 7 | ROYCE & ASSOCIATES LP | 297,582 | 2,556,000 | 1.75% | ||
| 8 | BlackRock Fund Advisors | 276,508 | 2,375,000 | 1.62% | ||
| 9 | Cormorant Asset Management, LP | 182,053 | 1,564,000 | 1.07% | ||
| 10 | Granahan Investment Management, LLC | 177,150 | 1,522,000 | 1.04% | ||
| 11 | Informed Momentum Co LLC | 135,584 | 1,165,000 | 0.80% | ||
| 12 | NEA Management Company, LLC | 133,488 | 1,147,000 | 0.78% | ||
| 13 | ACUTA CAPITAL PARTNERS, LLC | 128,566 | 1,104,000 | 0.75% | ||
| 14 | MARSHALL WACE, LLP | 123,670 | 1,062,000 | 0.73% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 78,700 | 676,000 | 0.46% | ||
| 16 | VANGUARD GROUP INC | 70,624 | 606,000 | 0.41% | ||
| 17 | Sio Capital Management, LLC | 62,592 | 538,000 | 0.37% | ||
| 18 | STATE STREET CORP | 60,878 | 522,000 | 0.36% | ||
| 19 | Opaleye Management Inc. | 55,000 | 472,000 | 0.32% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 52,794 | 453,000 | 0.31% | ||
| 21 | Foresite Capital Management II, LLC | 49,870 | 428,000 | 0.29% | ||
| 22 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,966 | 421,000 | 0.29% | ||
| 23 | GOLDMAN SACHS GROUP INC | 47,180 | 405,000 | 0.28% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 45,410 | 390,000 | 0.27% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 44,601 | 383,000 | 0.26% | ||
| 26 | BlackRock Investment Management, LLC | 36,918 | 317,000 | 0.22% | ||
| 27 | Bank of New York Mellon Corp | 31,701 | 272,000 | 0.19% | ||
| 28 | RUSSELL FRANK CO/ | 29,602 | 254,000 | 0.17% | ||
| 29 | HIGHLAND CAPITAL MANAGEMENT LP | 28,287 | 243,000 | 0.17% | ||
| 30 | MORGAN STANLEY | 23,273 | 200,000 | 0.14% | ||
| 31 | NORTHERN TRUST CORP | 20,861 | 179,000 | 0.12% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,013 | 163,000 | 0.11% | ||
| 33 | CAXTON CORP | 17,559 | 151,000 | 0.10% | ||
| 34 | TEACHERS ADVISORS, LLC | 14,904 | 128,000 | 0.09% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,462 | 116,000 | 0.08% | ||
| 36 | BlackRock Group LTD | 10,575 | 91,000 | 0.06% | ||
| 37 | MENTA CAPITAL LLC | 10,185 | 87,000 | 0.06% | ||
| 38 | COWEN INC. | 10,000 | 86,000 | 0.06% | ||
| 39 | DEUTSCHE BANK AG\ | 7,686 | 65,000 | 0.04% | ||
| 40 | Nationwide Fund Advisors | 6,560 | 56,000 | 0.04% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 6,100 | 52,399 | 0.04% | ||
| 42 | ROYAL BANK OF CANADA | 5,598 | 48,000 | 0.03% | ||
| 43 | BLACKROCK ADVISORS LLC | 5,082 | 44,000 | 0.03% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 5,038 | 43,000 | 0.03% | ||
| 45 | STRS OHIO | 3,300 | 28,000 | 0.02% | ||
| 46 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 2,500 | 21,000 | 0.01% | ||
| 47 | UBS Group AG | 2,201 | 19,000 | 0.01% | ||
| 48 | WELLS FARGO & COMPANY/MN | 2,021 | 17,000 | 0.01% | ||
| 49 | MSI Financial Services Inc | 1,100 | 9,000 | 0.01% | ||
| 50 | BNP PARIBAS FINANCIAL MARKETS | 866 | 7,439 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
