| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ProQuest Associates IV LLC | 5,062,363 | 31,438,000 | 20.89% | ||
| 2 | INVESTOR AB | 3,510,189 | 21,798,000 | 14.49% | ||
| 3 | Aisling Capital LLC | 2,983,797 | 18,529,000 | 12.31% | ||
| 4 | VIVO CAPITAL, LLC | 2,019,955 | 12,544,000 | 8.34% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,700,000 | 10,557,000 | 7.02% | ||
| 6 | CAXTON CORP | 1,428,871 | 8,873,000 | 5.90% | ||
| 7 | FRANKLIN RESOURCES INC | 1,400,000 | 8,694,000 | 5.78% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 1,064,217 | 6,609,000 | 4.39% | ||
| 9 | Invesco Ltd. | 677,855 | 4,209,000 | 2.80% | ||
| 10 | Cormorant Asset Management, LP | 557,053 | 3,459,000 | 2.30% | ||
| 11 | SENZAR ASSET MANAGEMENT, LLC | 412,869 | 2,563,916 | 1.70% | ||
| 12 | Granahan Investment Management, LLC | 376,196 | 2,336,000 | 1.55% | ||
| 13 | VANGUARD GROUP INC | 374,427 | 2,325,000 | 1.55% | ||
| 14 | BlackRock Fund Advisors | 340,810 | 2,116,000 | 1.41% | ||
| 15 | ROYCE & ASSOCIATES LP | 325,248 | 2,020,000 | 1.34% | ||
| 16 | J. Goldman & Co LP | 310,432 | 1,928,000 | 1.28% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 250,000 | 1,553,000 | 1.03% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 175,000 | 1,087,000 | 0.72% | ||
| 19 | Sio Capital Management, LLC | 165,188 | 1,026,000 | 0.68% | ||
| 20 | NEA Management Company, LLC | 133,488 | 829,000 | 0.55% | ||
| 21 | NORTHERN TRUST CORP | 132,622 | 824,000 | 0.55% | ||
| 22 | Informed Momentum Co LLC | 132,343 | 822,000 | 0.55% | ||
| 23 | STATE STREET CORP | 99,405 | 617,000 | 0.41% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 88,466 | 549,000 | 0.36% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 84,671 | 525,000 | 0.35% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 67,334 | 418,000 | 0.28% | ||
| 27 | First Light Asset Management, LLC | 61,469 | 382,000 | 0.25% | ||
| 28 | Bank of New York Mellon Corp | 57,257 | 355,000 | 0.24% | ||
| 29 | BlackRock Investment Management, LLC | 41,600 | 258,000 | 0.17% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 32,575 | 202,000 | 0.13% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,134 | 181,000 | 0.12% | ||
| 32 | RICE HALL JAMES & ASSOCIATES, LLC | 25,523 | 158,000 | 0.10% | ||
| 33 | TEACHERS ADVISORS, LLC | 14,904 | 93,000 | 0.06% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,462 | 84,000 | 0.06% | ||
| 35 | BLAIR WILLIAM & CO/IL | 11,000 | 68,000 | 0.05% | ||
| 36 | Spark Investment Management LLC | 10,400 | 64,000 | 0.04% | ||
| 37 | CITIGROUP INC | 9,408 | 58,000 | 0.04% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 9,400 | 58,000 | 0.04% | ||
| 39 | Nationwide Fund Advisors | 6,560 | 57,000 | 0.04% | ||
| 40 | WELLS FARGO & COMPANY/MN | 6,564 | 41,000 | 0.03% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 6,096 | 38,000 | 0.03% | ||
| 42 | ROYAL BANK OF CANADA | 4,900 | 30,000 | 0.02% | ||
| 43 | MORGAN STANLEY | 4,603 | 29,000 | 0.02% | ||
| 44 | BLACKROCK ADVISORS LLC | 4,444 | 28,000 | 0.02% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,712 | 16,000 | 0.01% | ||
| 46 | DEUTSCHE BANK AG\ | 2,062 | 12,000 | 0.01% | ||
| 47 | UBS Group AG | 959 | 6,000 | 0.00% | ||
| 48 | JPMORGAN CHASE & CO | 911 | 6,000 | 0.00% | ||
| 49 | MSI Financial Services Inc | 500 | 3,000 | 0.00% | ||
| 50 | Tower Research Capital LLC (TRC) | 199 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
