| 1 |
ProQuest Associates IV LLC |
5,062,363 |
38,525,000 |
21.06% |
|
|
| 2 |
INVESTOR AB |
3,510,189 |
26,713,000 |
14.60% |
|
|
| 3 |
Aisling Capital LLC |
2,583,797 |
19,663,000 |
10.75% |
|
|
| 4 |
VIVO CAPITAL, LLC |
2,019,955 |
15,372,000 |
8.40% |
|
|
| 5 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,700,000 |
12,937,000 |
7.07% |
|
|
| 6 |
CAXTON CORP |
1,580,491 |
12,028,000 |
6.58% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
1,400,000 |
10,654,000 |
5.82% |
|
|
| 8 |
RA CAPITAL MANAGEMENT, L.P. |
853,151 |
6,492,000 |
3.55% |
|
|
| 9 |
Invesco Ltd. |
675,063 |
5,138,000 |
2.81% |
|
|
| 10 |
Cormorant Asset Management, LP |
563,880 |
4,291,000 |
2.35% |
|
|
| 11 |
PERCEPTIVE ADVISORS LLC |
514,288 |
3,914,000 |
2.14% |
|
|
| 12 |
ROYCE & ASSOCIATES LP |
407,582 |
3,102,000 |
1.70% |
|
|
| 13 |
VANGUARD GROUP INC |
376,728 |
2,867,000 |
1.57% |
|
|
| 14 |
Granahan Investment Management, LLC |
365,416 |
2,781,000 |
1.52% |
|
|
| 15 |
SENZAR ASSET MANAGEMENT, LLC |
361,199 |
2,748,724 |
1.50% |
|
|
| 16 |
BlackRock Fund Advisors |
353,856 |
2,693,000 |
1.47% |
|
|
| 17 |
J. Goldman & Co LP |
256,980 |
1,956,000 |
1.07% |
|
|
| 18 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
250,000 |
1,903,000 |
1.04% |
|
|
| 19 |
NORTHERN TRUST CORP |
142,148 |
1,082,000 |
0.59% |
|
|
| 20 |
NEA Management Company, LLC |
133,488 |
1,016,000 |
0.56% |
|
|
| 21 |
STATE STREET CORP |
133,438 |
1,015,000 |
0.55% |
|
|
| 22 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
112,334 |
855,000 |
0.47% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
99,720 |
759,000 |
0.41% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
88,246 |
671,000 |
0.37% |
|
|
| 25 |
Bank of New York Mellon Corp |
63,612 |
484,000 |
0.26% |
|
|
| 26 |
First Light Asset Management, LLC |
59,701 |
454,000 |
0.25% |
|
|
| 27 |
BlackRock Investment Management, LLC |
45,455 |
346,000 |
0.19% |
|
|
| 28 |
PRICE T ROWE ASSOCIATES INC /MD/ |
41,132 |
313,000 |
0.17% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
39,541 |
301,000 |
0.16% |
|
|
| 30 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
30,769 |
234,000 |
0.13% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
27,834 |
212,000 |
0.12% |
|
|
| 32 |
AlpInvest Partners B.V. |
27,693 |
211,000 |
0.12% |
|
|
| 33 |
RICE HALL JAMES & ASSOCIATES, LLC |
25,317 |
193,000 |
0.11% |
|
|
| 34 |
TFS CAPITAL LLC |
21,599 |
164,000 |
0.09% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
19,401 |
148,000 |
0.08% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,462 |
103,000 |
0.06% |
|
|
| 37 |
Jasper Ridge Partners, L.P. |
12,160 |
93,000 |
0.05% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,400 |
72,000 |
0.04% |
|
|
| 39 |
GLENMEDE TRUST CO NA |
9,323 |
70,000 |
0.04% |
|
|
| 40 |
Nationwide Fund Advisors |
7,976 |
61,000 |
0.03% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,644 |
58,171 |
0.03% |
|
|
| 42 |
JPMORGAN CHASE & CO |
6,062 |
46,000 |
0.03% |
|
|
| 43 |
ROYAL BANK OF CANADA |
4,900 |
37,000 |
0.02% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
4,444 |
34,000 |
0.02% |
|
|
| 45 |
WELLS FARGO & COMPANY/MN |
4,481 |
34,000 |
0.02% |
|
|
| 46 |
BARCLAYS PLC |
3,400 |
26,000 |
0.01% |
|
|
| 47 |
MORGAN STANLEY |
3,092 |
24,000 |
0.01% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
1,986 |
15,000 |
0.01% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
854 |
7,000 |
0.00% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
582 |
4,000 |
0.00% |
|
|
