| 1 |
ProQuest Associates IV LLC |
4,668,663 |
45,566,000 |
28.38% |
|
|
| 2 |
INVESTOR AB |
3,510,189 |
34,260,000 |
21.34% |
|
|
| 3 |
Aisling Capital LLC |
2,983,797 |
29,122,000 |
18.14% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,399,740 |
13,661,000 |
8.51% |
|
|
| 5 |
Invesco Ltd. |
678,107 |
6,619,000 |
4.12% |
|
|
| 6 |
Granahan Investment Management, LLC |
389,486 |
3,801,000 |
2.37% |
|
|
| 7 |
SENZAR ASSET MANAGEMENT, LLC |
386,569 |
3,772,913 |
2.35% |
|
|
| 8 |
Opaleye Management Inc. |
300,000 |
2,928,000 |
1.82% |
|
|
| 9 |
ROYCE & ASSOCIATES LP |
297,582 |
2,904,000 |
1.81% |
|
|
| 10 |
BlackRock Fund Advisors |
281,015 |
2,743,000 |
1.71% |
|
|
| 11 |
Cormorant Asset Management, LP |
182,053 |
1,777,000 |
1.11% |
|
|
| 12 |
VANGUARD GROUP INC |
137,856 |
1,346,000 |
0.84% |
|
|
| 13 |
Informed Momentum Co LLC |
137,018 |
1,337,000 |
0.83% |
|
|
| 14 |
NEA Management Company, LLC |
133,488 |
1,303,000 |
0.81% |
|
|
| 15 |
MARSHALL WACE, LLP |
129,769 |
1,267,000 |
0.79% |
|
|
| 16 |
NORTHERN TRUST CORP |
103,027 |
1,005,000 |
0.63% |
|
|
| 17 |
HIGHLAND CAPITAL MANAGEMENT LP |
100,436 |
980,000 |
0.61% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
80,373 |
784,000 |
0.49% |
|
|
| 19 |
STATE STREET CORP |
79,923 |
781,000 |
0.49% |
|
|
| 20 |
Sio Capital Management, LLC |
74,267 |
725,000 |
0.45% |
|
|
| 21 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
67,334 |
657,000 |
0.41% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
58,803 |
573,000 |
0.36% |
|
|
| 23 |
Bank of New York Mellon Corp |
41,773 |
408,000 |
0.25% |
|
|
| 24 |
BlackRock Investment Management, LLC |
36,575 |
357,000 |
0.22% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,575 |
318,000 |
0.20% |
|
|
| 26 |
RICE HALL JAMES & ASSOCIATES, LLC |
25,917 |
253,000 |
0.16% |
|
|
| 27 |
CAXTON CORP |
23,035 |
225,000 |
0.14% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,281 |
188,000 |
0.12% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
14,904 |
145,000 |
0.09% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,462 |
132,000 |
0.08% |
|
|
| 31 |
CITADEL ADVISORS LLC |
10,861 |
106,000 |
0.07% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
9,400 |
92,000 |
0.06% |
|
|
| 33 |
Nationwide Fund Advisors |
6,560 |
64,000 |
0.04% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,096 |
59,000 |
0.04% |
|
|
| 35 |
ROYAL BANK OF CANADA |
4,900 |
48,000 |
0.03% |
|
|
| 36 |
MORGAN STANLEY |
4,823 |
47,000 |
0.03% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
4,540 |
45,000 |
0.03% |
|
|
| 38 |
UBS Group AG |
4,042 |
39,000 |
0.02% |
|
|
| 39 |
BLACKROCK ADVISORS LLC |
2,717 |
27,000 |
0.02% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
2,564 |
24,000 |
0.01% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
1,727 |
17,000 |
0.01% |
|
|
| 42 |
MSI Financial Services Inc |
1,000 |
10,000 |
0.01% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
941 |
9,184 |
0.01% |
|
|
| 44 |
CITIGROUP INC |
238 |
2,000 |
0.00% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
252 |
2,000 |
0.00% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
133 |
1,000 |
0.00% |
|
|
| 47 |
JPMORGAN CHASE & CO |
89 |
1,000 |
0.00% |
|
|
