| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 2,389,185 | 65,505,000 | 24.01% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,011,998 | 28,842,000 | 10.57% | ||
| 3 | FMR LLC | 991,755 | 28,265,000 | 10.36% | ||
| 4 | JPMORGAN CHASE & CO | 751,626 | 21,422,000 | 7.85% | ||
| 5 | SOROS FUND MANAGEMENT LLC | 660,148 | 18,814,000 | 6.89% | ||
| 6 | VANGUARD GROUP INC | 502,820 | 14,330,000 | 5.25% | ||
| 7 | DSAM Partners (London) Ltd | 447,237 | 12,746,000 | 4.67% | ||
| 8 | FRANKLIN RESOURCES INC | 355,944 | 10,144,000 | 3.72% | ||
| 9 | Visium Asset Management, LP | 297,000 | 8,465,000 | 3.10% | ||
| 10 | Artal Group S.A. | 210,000 | 5,985,000 | 2.19% | ||
| 11 | VIKING GLOBAL INVESTORS LP | 200,000 | 5,700,000 | 2.09% | ||
| 12 | BlackRock Fund Advisors | 191,707 | 5,464,000 | 2.00% | ||
| 13 | Capital World Investors | 190,000 | 5,415,000 | 1.98% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 129,410 | 3,688,000 | 1.35% | ||
| 15 | FRONTIER CAPITAL MANAGEMENT CO LLC | 116,775 | 3,328,000 | 1.22% | ||
| 16 | Cormorant Asset Management, LP | 100,000 | 2,850,000 | 1.04% | ||
| 17 | Rock Springs Capital Management LP | 82,474 | 2,351,000 | 0.86% | ||
| 18 | JENNISON ASSOCIATES LLC | 77,905 | 2,220,000 | 0.81% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 75,600 | 2,155,000 | 0.79% | ||
| 20 | STATE STREET CORP | 72,100 | 2,055,000 | 0.75% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 71,674 | 2,043,000 | 0.75% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 67,970 | 1,937,000 | 0.71% | ||
| 23 | Peregrine Asset Advisers, Inc. | 48,490 | 1,382,000 | 0.51% | ||
| 24 | PUTNAM INVESTMENTS LLC | 46,550 | 1,327,000 | 0.49% | ||
| 25 | QVT Financial LP | 40,000 | 1,140,000 | 0.42% | ||
| 26 | Duquesne Family Office LLC | 40,000 | 1,140,000 | 0.42% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 39,900 | 1,137,000 | 0.42% | ||
| 28 | JANE STREET GROUP, LLC | 35,346 | 1,007,000 | 0.37% | ||
| 29 | FEDERATED HERMES, INC. | 30,000 | 855,000 | 0.31% | ||
| 30 | BLACKROCK ADVISORS LLC | 29,777 | 849,000 | 0.31% | ||
| 31 | Bank of New York Mellon Corp | 28,940 | 825,000 | 0.30% | ||
| 32 | ROYAL BANK OF CANADA | 28,800 | 821,000 | 0.30% | ||
| 33 | CITADEL ADVISORS LLC | 28,257 | 805,000 | 0.30% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,731 | 762,000 | 0.28% | ||
| 35 | PointState Capital LP | 25,000 | 713,000 | 0.26% | ||
| 36 | SHIKIAR ASSET MANAGEMENT INC | 25,000 | 712,000 | 0.26% | ||
| 37 | BlackRock Investment Management, LLC | 23,365 | 666,000 | 0.24% | ||
| 38 | NORTHERN TRUST CORP | 22,907 | 652,000 | 0.24% | ||
| 39 | MORGAN STANLEY | 22,297 | 636,000 | 0.23% | ||
| 40 | CITY NATIONAL BANK | 20,000 | 570,000 | 0.21% | ||
| 41 | MARINER INVESTMENT GROUP LLC | 16,507 | 470,000 | 0.17% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,900 | 453,000 | 0.17% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 10,860 | 309,000 | 0.11% | ||
| 44 | Nationwide Fund Advisors | 10,206 | 291,000 | 0.11% | ||
| 45 | ARROWGRASS CAPITAL PARTNERS (US) LP | 10,000 | 285,000 | 0.10% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 10,000 | 285,000 | 0.10% | ||
| 47 | TEACHERS ADVISORS, LLC | 8,040 | 229,000 | 0.08% | ||
| 48 | WELLS FARGO & COMPANY/MN | 6,500 | 185,000 | 0.07% | ||
| 49 | SG Americas Securities, LLC | 4,800 | 137,000 | 0.05% | ||
| 50 | UBS AG | 3,459 | 99,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
