| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 5,124,885 | 295,603,000 | 19.42% | ||
| 2 | FMR LLC | 2,825,942 | 163,000,000 | 10.71% | ||
| 3 | Wildcat Capital Management, LLC | 2,358,084 | 136,014,000 | 8.94% | ||
| 4 | VANGUARD GROUP INC | 1,520,269 | 87,689,000 | 5.76% | ||
| 5 | Capital World Investors | 1,278,000 | 73,715,000 | 4.84% | ||
| 6 | JPMORGAN CHASE & CO | 1,231,433 | 71,028,000 | 4.67% | ||
| 7 | Capital International Investors | 724,700 | 41,801,000 | 2.75% | ||
| 8 | FRONTIER CAPITAL MANAGEMENT CO LLC | 722,774 | 41,690,000 | 2.74% | ||
| 9 | BlackRock Fund Advisors | 720,562 | 41,562,000 | 2.73% | ||
| 10 | SOROS FUND MANAGEMENT LLC | 660,148 | 38,077,000 | 2.50% | ||
| 11 | J.P. Morgan Private Wealth Advisors LLC | 506,595 | 29,220,000 | 1.92% | ||
| 12 | STATE STREET CORP | 503,218 | 29,024,000 | 1.91% | ||
| 13 | CAPITAL GUARDIAN TRUST CO | 496,300 | 28,627,000 | 1.88% | ||
| 14 | FRANKLIN RESOURCES INC | 407,544 | 23,507,000 | 1.54% | ||
| 15 | RTW INVESTMENTS, LP | 375,623 | 21,666,000 | 1.42% | ||
| 16 | Artal Group S.A. | 375,000 | 21,630,000 | 1.42% | ||
| 17 | DSAM Partners (London) Ltd | 333,813 | 19,254,000 | 1.26% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 328,800 | 18,965,000 | 1.25% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 307,321 | 17,726,000 | 1.16% | ||
| 20 | EcoR1 Capital, LLC | 281,400 | 16,231,000 | 1.07% | ||
| 21 | MENORA MIVTACHIM HOLDINGS LTD. | 268,530 | 15,489,000 | 1.02% | ||
| 22 | RS INVESTMENT MANAGEMENT CO LLC | 253,110 | 14,599,000 | 0.96% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,000 | 12,690,000 | 0.83% | Put | |
| 24 | Silver Rock Financial LLC | 179,225 | 10,338,000 | 0.68% | ||
| 25 | PFM Health Sciences, LP | 175,994 | 10,151,000 | 0.67% | ||
| 26 | BELLEVUE ASSET MANAGEMENT AG | 168,000 | 9,690,000 | 0.64% | ||
| 27 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 141,360 | 8,153,000 | 0.54% | ||
| 28 | GUGGENHEIM CAPITAL LLC | 127,737 | 7,368,000 | 0.48% | ||
| 29 | NORTHERN TRUST CORP | 114,820 | 6,623,000 | 0.44% | ||
| 30 | STIFEL FINANCIAL CORP | 114,332 | 6,594,000 | 0.43% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,000 | 6,518,000 | 0.43% | Call | |
| 32 | Parkwood LLC | 104,300 | 6,016,000 | 0.40% | ||
| 33 | Lamond Capital Partners LLC | 104,250 | 6,013,000 | 0.40% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 101,987 | 5,883,000 | 0.39% | ||
| 35 | Cormorant Asset Management, LP | 100,000 | 5,768,000 | 0.38% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,360 | 5,500,000 | 0.36% | ||
| 37 | OppenheimerFunds, Inc. | 88,037 | 5,078,000 | 0.33% | ||
| 38 | CAPITAL INTERNATIONAL LTD /CA/ | 83,400 | 4,811,000 | 0.32% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 83,282 | 4,803,000 | 0.32% | ||
| 40 | PICTET ASSET MANAGEMENT LTD | 95,100 | 4,791,000 | 0.31% | ||
| 41 | Allianz Asset Management GmbH | 81,620 | 4,707,000 | 0.31% | ||
| 42 | STONERIDGE INVESTMENT PARTNERS LLC | 81,327 | 4,691,000 | 0.31% | ||
| 43 | Candriam S.C.A. | 80,000 | 4,615,000 | 0.30% | ||
| 44 | Opaleye Management Inc. | 76,000 | 4,384,000 | 0.29% | ||
| 45 | Rock Springs Capital Management LP | 71,474 | 4,123,000 | 0.27% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 70,902 | 4,090,000 | 0.27% | ||
| 47 | Bank of New York Mellon Corp | 68,940 | 3,977,000 | 0.26% | ||
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 65,970 | 3,805,000 | 0.25% | ||
| 49 | UBS Group AG | 65,954 | 3,804,000 | 0.25% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 63,793 | 3,680,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
