| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 4,986,299 | 334,830,000 | 24.35% | ||
| 2 | Wildcat Capital Management, LLC | 2,358,084 | 135,991,000 | 9.89% | ||
| 3 | FMR LLC | 1,968,094 | 113,500,000 | 8.25% | ||
| 4 | Capital World Investors | 1,261,000 | 84,676,000 | 6.16% | ||
| 5 | JPMORGAN CHASE & CO | 826,566 | 47,668,000 | 3.47% | ||
| 6 | J.P. Morgan Private Wealth Advisors LLC | 729,265 | 42,057,000 | 3.06% | ||
| 7 | VANGUARD GROUP INC | 726,363 | 41,890,000 | 3.05% | ||
| 8 | Capital International Investors | 724,700 | 41,793,000 | 3.04% | ||
| 9 | BlackRock Fund Advisors | 687,063 | 39,623,000 | 2.88% | ||
| 10 | SOROS FUND MANAGEMENT LLC | 680,148 | 39,224,000 | 2.85% | ||
| 11 | CAPITAL GUARDIAN TRUST CO | 495,500 | 33,273,000 | 2.42% | ||
| 12 | Silver Rock Financial LLC | 476,563 | 27,483,000 | 2.00% | ||
| 13 | EcoR1 Capital, LLC | 438,400 | 25,283,000 | 1.84% | ||
| 14 | FRANKLIN RESOURCES INC | 437,644 | 25,239,000 | 1.84% | ||
| 15 | DSAM Partners (London) Ltd | 399,571 | 23,043,000 | 1.68% | ||
| 16 | Lamond Capital Partners LLC | 365,900 | 21,101,000 | 1.53% | ||
| 17 | Artal Group S.A. | 350,000 | 20,185,000 | 1.47% | ||
| 18 | RS INVESTMENT MANAGEMENT CO LLC | 316,410 | 18,247,000 | 1.33% | ||
| 19 | FRONTIER CAPITAL MANAGEMENT CO LLC | 262,249 | 15,124,000 | 1.10% | ||
| 20 | Cormorant Asset Management, LP | 255,000 | 14,706,000 | 1.07% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 235,498 | 13,581,000 | 0.99% | ||
| 22 | PFM Health Sciences, LP | 216,652 | 12,494,000 | 0.91% | ||
| 23 | PointState Capital LP | 192,500 | 11,101,000 | 0.81% | ||
| 24 | DEERFIELD MANAGEMENT COMPANY, L.P. | 155,799 | 8,985,000 | 0.65% | ||
| 25 | CQS Cayman LP | 145,000 | 8,362,000 | 0.61% | ||
| 26 | STIFEL FINANCIAL CORP | 90,591 | 8,129,000 | 0.59% | ||
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 129,745 | 7,482,000 | 0.54% | ||
| 28 | STATE STREET CORP | 119,208 | 6,874,000 | 0.50% | ||
| 29 | Rock Springs Capital Management LP | 114,474 | 6,602,000 | 0.48% | ||
| 30 | SPHERA FUNDS MANAGEMENT LTD. | 110,970 | 6,400,000 | 0.47% | ||
| 31 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 106,778 | 6,157,000 | 0.45% | ||
| 32 | NORTHERN TRUST CORP | 102,514 | 5,912,000 | 0.43% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 98,697 | 5,692,000 | 0.41% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 90,883 | 5,241,000 | 0.38% | ||
| 35 | GILDER GAGNON HOWE & CO LLC | 86,391 | 4,982,000 | 0.36% | ||
| 36 | OppenheimerFunds, Inc. | 85,714 | 4,943,000 | 0.36% | ||
| 37 | CAPITAL INTERNATIONAL LTD /CA/ | 83,000 | 4,787,000 | 0.35% | ||
| 38 | JENNISON ASSOCIATES LLC | 77,821 | 4,488,000 | 0.33% | ||
| 39 | Opaleye Management Inc. | 76,000 | 4,383,000 | 0.32% | ||
| 40 | LORD, ABBETT & CO. LLC | 75,469 | 4,352,000 | 0.32% | ||
| 41 | Candriam S.C.A. | 72,000 | 4,152,000 | 0.30% | ||
| 42 | CITADEL ADVISORS LLC | 71,497 | 4,123,000 | 0.30% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 68,641 | 3,958,000 | 0.29% | ||
| 44 | Ghost Tree Capital, LLC | 60,000 | 3,460,000 | 0.25% | ||
| 45 | Bank of New York Mellon Corp | 58,392 | 3,368,000 | 0.24% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,900 | 3,166,000 | 0.23% | Put | |
| 47 | BLACKROCK ADVISORS LLC | 51,721 | 2,983,000 | 0.22% | ||
| 48 | ARROWGRASS CAPITAL PARTNERS (US) LP | 50,977 | 2,940,000 | 0.21% | ||
| 49 | PUTNAM INVESTMENTS LLC | 46,550 | 2,685,000 | 0.20% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,200 | 2,607,000 | 0.19% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
