| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 5,982,753 | 274,668,000 | 15.90% | ||
| 2 | JPMORGAN CHASE & CO | 2,788,395 | 128,014,000 | 7.41% | ||
| 3 | VANGUARD GROUP INC | 2,761,527 | 126,782,000 | 7.34% | ||
| 4 | FMR LLC | 2,711,628 | 124,491,000 | 7.21% | ||
| 5 | Wildcat Capital Management, LLC | 2,358,084 | 108,260,000 | 6.27% | ||
| 6 | VIKING GLOBAL INVESTORS LP | 2,259,828 | 103,749,000 | 6.01% | ||
| 7 | BlackRock Fund Advisors | 1,508,215 | 69,242,000 | 4.01% | ||
| 8 | STATE STREET CORP | 1,332,147 | 61,162,000 | 3.54% | ||
| 9 | Capital World Investors | 1,040,000 | 47,746,000 | 2.76% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 956,903 | 43,931,000 | 2.54% | ||
| 11 | CITADEL ADVISORS LLC | 752,348 | 34,540,000 | 2.00% | ||
| 12 | BB BIOTECH AG | 750,000 | 34,433,000 | 1.99% | ||
| 13 | J.P. Morgan Private Wealth Advisors LLC | 739,867 | 33,967,000 | 1.97% | ||
| 14 | Capital International Investors | 724,700 | 33,271,000 | 1.93% | ||
| 15 | MENORA MIVTACHIM HOLDINGS LTD. | 494,988 | 22,725,000 | 1.32% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 492,438 | 22,608,000 | 1.31% | ||
| 17 | Artal Group S.A. | 485,000 | 22,266,000 | 1.29% | ||
| 18 | CAPITAL GUARDIAN TRUST CO | 451,700 | 20,738,000 | 1.20% | ||
| 19 | FRONTIER CAPITAL MANAGEMENT CO LLC | 447,941 | 20,565,000 | 1.19% | ||
| 20 | FRANKLIN RESOURCES INC | 402,444 | 18,476,000 | 1.07% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 377,578 | 17,334,000 | 1.00% | ||
| 22 | NORTHERN TRUST CORP | 376,290 | 17,276,000 | 1.00% | ||
| 23 | RTW INVESTMENTS, LP | 343,503 | 15,770,000 | 0.91% | ||
| 24 | PFM Health Sciences, LP | 313,765 | 14,405,000 | 0.83% | ||
| 25 | NORGES BANK | 302,169 | 13,873,000 | 0.80% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 283,601 | 13,020,000 | 0.75% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 282,806 | 12,983,000 | 0.75% | ||
| 28 | DSAM Partners (London) Ltd | 256,550 | 11,778,000 | 0.68% | ||
| 29 | LLBH PRIVATE WEALTH MANAGEMENT, LLC | 250,040 | 11,479,000 | 0.66% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 238,900 | 10,968,000 | 0.63% | Call | |
| 31 | Bank of New York Mellon Corp | 201,472 | 9,249,000 | 0.54% | ||
| 32 | MIGDAL INSURANCE & FINANCIAL HOLDINGS LTD. | 200,000 | 9,182,000 | 0.53% | ||
| 33 | VIVO CAPITAL, LLC | 193,193 | 8,869,000 | 0.51% | ||
| 34 | ROYAL BANK OF CANADA | 188,897 | 8,672,000 | 0.50% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 158,118 | 7,259,000 | 0.42% | ||
| 36 | EcoR1 Capital, LLC | 150,000 | 6,887,000 | 0.40% | ||
| 37 | Senator Investment Group LP | 150,000 | 6,886,000 | 0.40% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 148,600 | 6,822,000 | 0.39% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 146,900 | 6,744,000 | 0.39% | Put | |
| 40 | Candriam S.C.A. | 138,500 | 6,324,000 | 0.37% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 136,626 | 6,273,000 | 0.36% | ||
| 42 | BlackRock Investment Management, LLC | 112,234 | 5,153,000 | 0.30% | ||
| 43 | Silver Rock Financial LLC | 109,199 | 5,013,000 | 0.29% | ||
| 44 | Zurcher Kantonalbank (Zurich Cantonalbank) | 102,474 | 4,705,000 | 0.27% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 95,700 | 4,394,000 | 0.25% | ||
| 46 | SG Americas Securities, LLC | 89,004 | 4,086,000 | 0.24% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,936 | 4,083,000 | 0.24% | ||
| 48 | TEACHERS ADVISORS, LLC | 86,351 | 3,964,000 | 0.23% | ||
| 49 | Rock Springs Capital Management LP | 80,000 | 3,673,000 | 0.21% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 75,449 | 3,464,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
