| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 6,109,771 | 273,962,000 | 13.36% | ||
| 2 | VANGUARD GROUP INC | 3,154,258 | 141,437,000 | 6.90% | ||
| 3 | JPMORGAN CHASE & CO | 2,994,847 | 134,288,000 | 6.55% | ||
| 4 | Wildcat Capital Management, LLC | 2,358,084 | 105,736,000 | 5.16% | ||
| 5 | BlackRock Fund Advisors | 1,994,083 | 89,415,000 | 4.36% | ||
| 6 | STATE STREET CORP | 1,967,213 | 88,217,000 | 4.30% | ||
| 7 | Capital World Investors | 1,825,000 | 81,833,000 | 3.99% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,534,494 | 68,807,000 | 3.36% | ||
| 9 | Capital International Investors | 1,314,200 | 58,929,000 | 2.87% | ||
| 10 | MENORA MIVTACHIM HOLDINGS LTD. | 1,258,899 | 56,449,000 | 2.75% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,153,353 | 51,716,000 | 2.52% | ||
| 12 | BAINCO INTERNATIONAL INVESTORS | 1,151,540 | 51,635,000 | 2.52% | ||
| 13 | PFM Health Sciences, LP | 997,464 | 44,726,000 | 2.18% | ||
| 14 | FMR LLC | 903,573 | 40,516,000 | 1.98% | ||
| 15 | BB BIOTECH AG | 800,000 | 35,872,000 | 1.75% | ||
| 16 | ROYAL BANK OF CANADA | 729,040 | 32,690,000 | 1.59% | ||
| 17 | WADDELL & REED FINANCIAL INC | 707,600 | 31,729,000 | 1.55% | ||
| 18 | HIGHLINE CAPITAL MANAGEMENT, L.P. | 702,300 | 31,491,000 | 1.54% | ||
| 19 | JENNISON ASSOCIATES LLC | 622,607 | 27,918,000 | 1.36% | ||
| 20 | FIRST TRUST ADVISORS LP | 607,272 | 27,230,000 | 1.33% | ||
| 21 | AMERICAN CENTURY COMPANIES INC | 590,343 | 26,471,000 | 1.29% | ||
| 22 | FRONTIER CAPITAL MANAGEMENT CO LLC | 466,492 | 20,918,000 | 1.02% | ||
| 23 | CAPITAL GUARDIAN TRUST CO | 463,700 | 20,792,000 | 1.01% | ||
| 24 | NORTHERN TRUST CORP | 450,292 | 20,191,000 | 0.98% | ||
| 25 | VICTORY CAPITAL MANAGEMENT INC | 436,774 | 19,585,000 | 0.96% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 404,137 | 18,122,000 | 0.88% | ||
| 27 | J.P. Morgan Private Wealth Advisors LLC | 390,419 | 17,506,000 | 0.85% | ||
| 28 | NORGES BANK | 375,745 | 16,848,000 | 0.82% | ||
| 29 | SECTORAL ASSET MANAGEMENT INC | 372,223 | 16,690,000 | 0.81% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 345,003 | 15,469,000 | 0.75% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 333,600 | 14,959,000 | 0.73% | Put | |
| 32 | FRANKLIN RESOURCES INC | 306,144 | 13,727,000 | 0.67% | ||
| 33 | DEERFIELD MANAGEMENT COMPANY, L.P. | 297,902 | 13,358,000 | 0.65% | ||
| 34 | PICTET ASSET MANAGEMENT LTD | 287,370 | 12,886,000 | 0.63% | ||
| 35 | LLBH PRIVATE WEALTH MANAGEMENT, LLC | 250,040 | 11,212,000 | 0.55% | ||
| 36 | Artal Group S.A. | 250,000 | 11,210,000 | 0.55% | ||
| 37 | Point72 Asset Management, L.P. | 244,722 | 10,973,000 | 0.54% | ||
| 38 | Candriam S.C.A. | 236,550 | 10,606,000 | 0.52% | ||
| 39 | BALYASNY ASSET MANAGEMENT L.P. | 210,000 | 9,416,000 | 0.46% | Put | |
| 40 | CITIGROUP INC | 208,631 | 9,355,000 | 0.46% | ||
| 41 | Bank of New York Mellon Corp | 205,243 | 9,202,000 | 0.45% | ||
| 42 | MIGDAL INSURANCE & FINANCIAL HOLDINGS LTD. | 200,111 | 8,973,000 | 0.44% | ||
| 43 | DEUTSCHE BANK AG\ | 186,539 | 8,362,000 | 0.41% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173,342 | 7,773,000 | 0.38% | ||
| 45 | OppenheimerFunds, Inc. | 161,120 | 7,225,000 | 0.35% | ||
| 46 | PINNACLE ASSOCIATES LTD | 157,990 | 7,084,000 | 0.35% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,300 | 6,874,000 | 0.34% | Call | |
| 48 | NEXTHERA CAPITAL LP | 150,000 | 6,726,000 | 0.33% | ||
| 49 | BlackRock Investment Management, LLC | 146,855 | 6,585,000 | 0.32% | ||
| 50 | MORGAN STANLEY | 142,126 | 6,372,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
