| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 5,357,460 | 298,303,000 | 15.44% | ||
| 2 | FMR LLC | 3,172,403 | 176,639,000 | 9.14% | ||
| 3 | VIKING GLOBAL INVESTORS LP | 2,472,580 | 137,673,000 | 7.13% | ||
| 4 | Wildcat Capital Management, LLC | 2,358,084 | 131,298,000 | 6.80% | ||
| 5 | VANGUARD GROUP INC | 2,123,238 | 118,222,000 | 6.12% | ||
| 6 | JPMORGAN CHASE & CO | 1,529,380 | 85,156,000 | 4.41% | ||
| 7 | BlackRock Fund Advisors | 1,348,437 | 75,081,000 | 3.89% | ||
| 8 | Capital World Investors | 1,296,000 | 72,161,000 | 3.74% | ||
| 9 | STATE STREET CORP | 904,951 | 50,387,000 | 2.61% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 797,499 | 44,405,000 | 2.30% | ||
| 11 | BB BIOTECH AG | 750,000 | 41,760,000 | 2.16% | ||
| 12 | FRONTIER CAPITAL MANAGEMENT CO LLC | 738,066 | 41,096,000 | 2.13% | ||
| 13 | Capital International Investors | 724,700 | 40,351,000 | 2.09% | ||
| 14 | PFM Health Sciences, LP | 682,577 | 38,006,000 | 1.97% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 584,560 | 32,548,000 | 1.69% | ||
| 16 | CAPITAL GUARDIAN TRUST CO | 470,600 | 26,203,000 | 1.36% | ||
| 17 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 420,617 | 23,419,000 | 1.21% | ||
| 18 | MENORA MIVTACHIM HOLDINGS LTD. | 410,002 | 22,828,000 | 1.18% | ||
| 19 | FRANKLIN RESOURCES INC | 407,544 | 22,692,000 | 1.17% | ||
| 20 | Artal Group S.A. | 390,000 | 21,715,000 | 1.12% | ||
| 21 | RTW INVESTMENTS, LP | 375,476 | 20,907,000 | 1.08% | ||
| 22 | J.P. Morgan Private Wealth Advisors LLC | 370,676 | 20,639,000 | 1.07% | ||
| 23 | NORTHERN TRUST CORP | 318,432 | 17,730,000 | 0.92% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 296,100 | 16,487,000 | 0.85% | Call | |
| 25 | EcoR1 Capital, LLC | 281,400 | 15,668,000 | 0.81% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 271,266 | 15,104,000 | 0.78% | ||
| 27 | NORGES BANK | 268,146 | 14,930,000 | 0.77% | ||
| 28 | DSAM Partners (London) Ltd | 265,640 | 14,791,000 | 0.77% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 242,676 | 13,512,000 | 0.70% | ||
| 30 | BALYASNY ASSET MANAGEMENT L.P. | 231,656 | 12,899,000 | 0.67% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,800 | 9,956,000 | 0.52% | Put | |
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 165,428 | 9,211,000 | 0.48% | ||
| 33 | Bank of New York Mellon Corp | 154,013 | 8,576,000 | 0.44% | ||
| 34 | Artal Group S.A. | 150,000 | 8,352,000 | 0.43% | Call | |
| 35 | EVENTIDE ASSET MANAGEMENT, LLC | 140,000 | 7,795,000 | 0.40% | ||
| 36 | Silver Rock Financial LLC | 139,225 | 7,752,000 | 0.40% | ||
| 37 | SABBY MANAGEMENT, LLC | 137,099 | 7,634,000 | 0.40% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 128,999 | 7,183,000 | 0.37% | ||
| 39 | State of Tennessee, Department of Treasury | 126,962 | 7,069,000 | 0.37% | ||
| 40 | BELLEVUE ASSET MANAGEMENT AG | 119,500 | 6,654,000 | 0.34% | ||
| 41 | UBS Group AG | 111,998 | 6,236,000 | 0.32% | ||
| 42 | GLG LLC | 109,031 | 6,071,000 | 0.31% | ||
| 43 | Zurcher Kantonalbank (Zurich Cantonalbank) | 104,005 | 5,791,000 | 0.30% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 102,743 | 5,721,000 | 0.30% | ||
| 45 | BlackRock Investment Management, LLC | 96,118 | 5,352,000 | 0.28% | ||
| 46 | Invesco Ltd. | 94,678 | 5,272,000 | 0.27% | ||
| 47 | Jefferies Group LLC | 92,400 | 5,145,000 | 0.27% | Put | |
| 48 | Rock Springs Capital Management LP | 91,500 | 5,095,000 | 0.26% | ||
| 49 | SG Americas Securities, LLC | 88,879 | 4,949,000 | 0.26% | ||
| 50 | Candriam S.C.A. | 88,200 | 4,911,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
