| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 6,075,623 | 339,384,000 | 14.80% | ||
| 2 | VANGUARD GROUP INC | 3,034,136 | 169,487,000 | 7.39% | ||
| 3 | JPMORGAN CHASE & CO | 2,607,976 | 145,683,000 | 6.35% | ||
| 4 | Wildcat Capital Management, LLC | 2,358,084 | 131,723,000 | 5.74% | ||
| 5 | BlackRock Fund Advisors | 1,751,216 | 97,823,000 | 4.27% | ||
| 6 | STATE STREET CORP | 1,583,520 | 88,454,000 | 3.86% | ||
| 7 | Capital World Investors | 1,559,000 | 87,086,000 | 3.80% | ||
| 8 | Capital International Investors | 1,314,200 | 73,411,000 | 3.20% | ||
| 9 | FMR LLC | 1,262,173 | 70,505,000 | 3.07% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,058,999 | 59,156,000 | 2.58% | ||
| 11 | MENORA MIVTACHIM HOLDINGS LTD. | 1,008,899 | 56,357,000 | 2.46% | ||
| 12 | BB BIOTECH AG | 800,000 | 44,688,000 | 1.95% | ||
| 13 | WADDELL & REED FINANCIAL INC | 715,700 | 39,979,000 | 1.74% | ||
| 14 | BAINCO INTERNATIONAL INVESTORS | 671,540 | 37,512,000 | 1.64% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 669,100 | 37,376,000 | 1.63% | Put | |
| 16 | ROYAL BANK OF CANADA | 646,391 | 36,108,000 | 1.57% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 521,568 | 29,135,000 | 1.27% | ||
| 18 | VIKING GLOBAL INVESTORS LP | 516,815 | 28,869,000 | 1.26% | ||
| 19 | HIGHLINE CAPITAL MANAGEMENT, L.P. | 505,400 | 28,232,000 | 1.23% | ||
| 20 | PFM Health Sciences, LP | 501,086 | 27,991,000 | 1.22% | ||
| 21 | CAPITAL GUARDIAN TRUST CO | 471,300 | 26,327,000 | 1.15% | ||
| 22 | VICTORY CAPITAL MANAGEMENT INC | 457,914 | 25,579,000 | 1.12% | ||
| 23 | NORTHERN TRUST CORP | 445,627 | 24,893,000 | 1.09% | ||
| 24 | FRANKLIN RESOURCES INC | 408,844 | 22,838,000 | 1.00% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 392,846 | 21,944,000 | 0.96% | ||
| 26 | J.P. Morgan Private Wealth Advisors LLC | 368,983 | 20,611,000 | 0.90% | ||
| 27 | NORGES BANK | 375,745 | 20,047,000 | 0.87% | ||
| 28 | AMERICAN CENTURY COMPANIES INC | 346,171 | 19,337,000 | 0.84% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 320,221 | 17,887,000 | 0.78% | ||
| 30 | Artal Group S.A. | 315,000 | 17,596,000 | 0.77% | ||
| 31 | GOLDMAN SACHS GROUP INC | 278,800 | 15,574,000 | 0.68% | Put | |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,800 | 15,406,000 | 0.67% | Call | |
| 33 | PICTET ASSET MANAGEMENT LTD | 263,695 | 14,730,000 | 0.64% | ||
| 34 | LLBH PRIVATE WEALTH MANAGEMENT, LLC | 250,040 | 13,967,000 | 0.61% | ||
| 35 | FRONTIER CAPITAL MANAGEMENT CO LLC | 237,718 | 13,279,000 | 0.58% | ||
| 36 | DSAM Partners (London) Ltd | 218,312 | 12,195,000 | 0.53% | ||
| 37 | DEUTSCHE BANK AG\ | 209,849 | 11,721,000 | 0.51% | ||
| 38 | Bank of New York Mellon Corp | 207,471 | 11,589,000 | 0.51% | ||
| 39 | MIGDAL INSURANCE & FINANCIAL HOLDINGS LTD. | 200,000 | 11,172,000 | 0.49% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 164,448 | 9,187,000 | 0.40% | ||
| 41 | GOLDMAN SACHS GROUP INC | 160,300 | 8,954,000 | 0.39% | Call | |
| 42 | MILLENNIUM MANAGEMENT LLC | 160,000 | 8,938,000 | 0.39% | Call | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 158,710 | 8,866,000 | 0.39% | ||
| 44 | EVENTIDE ASSET MANAGEMENT, LLC | 148,600 | 8,301,000 | 0.36% | ||
| 45 | BlackRock Investment Management, LLC | 147,320 | 8,229,000 | 0.36% | ||
| 46 | BARCLAYS PLC | 120,000 | 6,703,000 | 0.29% | Put | |
| 47 | BARCLAYS PLC | 120,000 | 6,703,000 | 0.29% | Call | |
| 48 | Candriam S.C.A. | 119,550 | 6,678,000 | 0.29% | ||
| 49 | SECTORAL ASSET MANAGEMENT INC | 116,326 | 6,498,000 | 0.28% | ||
| 50 | JENNISON ASSOCIATES LLC | 114,879 | 6,417,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
